CROI 2016 Program at a Glance

Program and Agenda

WEDNESDAY, FEBRUARY 24, 2016

963 Efavirenz Toxicity Manifesting As Cerebellar Ataxia: Case Series From South Africa EbrahimVariava 1 ; Farai R. Sigauke 2 ; Petudzai Muchichwa 2 ; Gary Maartens 3 ; Neil Martinson 4 1 Klerksdorp/TshepongHosp,Klerksdorp,SouthAfrica; 2 Klerksdorp TshepongHospComplex,NorthwestDeptofHlth,Klerksdorp,South Africa; 3 UnivofCapeTown,CapeTown,SouthAfrica; 4 PerinatalHIVRsr Unit,Diepkloof,SouthAfrica 2:45 PM-4:00 PM Modeling: Understanding Epidemics and ART Programs 1042 State-Space Models for Engagement, Retention, and Reentry in the HIV Care Cascade Hana Lee 1 ; Becky L. Genberg 1 ; Monicah Nyambura 2 ; Joseph Hogan 1 ; Paula Braitstein 3 ; Edwin Sang 2 1 BrownUniv,Providence,RI,USA; 2 AcademicModelProvidingAccess to Hlthcare,Eldoret,Kenya; 3 UnivofToronto,Toronto,ON,Canada 1043 How Far AreWe From Early cART for All? A Nationwide Population-Based Study in France Virginie Supervie 1 ; Jean-Marc Lacombe 2 ; Rosemary Dray-Spira 2 ; Dominique Costagliola 1 ; for the FHDH-ANRS CO4 study group 1 SorbonneUnivs,Paris,France; 2 INSERMU1136,Paris,France 1044 Using Treatment As Prevention Could Eliminate the HIV Epidemic in MSM in Copenhagen Justin Okano 1 ; Danielle Robbins 1 ; Laurence Palk 1 ; Jan Gerstoft 2 ; Niels Obel 2 ; Sally Blower 1 1 UnivofCaliforniaLosAngeles,LosAngeles,CA,USA; 2 CopenhagenUniv Hosp,Rigshospitalet,Copenhagen,Denmark 1045 Estimated HIV Transmissions to Female Partners of HIV-Infected Men CyprianWejnert 1 ; Eli Rosenberg 2 ; Heather Bradley 1 ; Gabriela Paz-Bailey 1 ; H. Irene Hall 1 ; Jacek Skarbinski 1 ; Jonathan Mermin 1 ; Jeremy Grey 2 1 CDC,Atlanta,GA,USA; 2 EmoryUniv,Atlanta,GA,USA 1046 Utility of the 1% HIV Prevalence Threshold in Defining Concentrated HIV Epidemics Michael Pickles 1 ; Marie-Claude Boily 1 ; Sharmistha Mishra 2 1 ImperialCollLondon,London,UK; 2 UnivofToronto,Toronto,ON,Canada 1047 The Role of YoungWomen in the HIV Epidemic in Benin, West Africa John R.Williams 1 ; Eugene L. Geidelberg 1 ; Michel Alary 2 ; Sharmistha Mishra 3 ; Marie-Claude Boily 1 1 ImperialCollLondon,London,UK; 2 UnivLaval,Québec,QC,Canada; 3 UnivofToronto,Toronto,ON,Canada Session P-Y1 Poster Abstracts Hall D

Session P-A2 Poster Abstracts

Hall A/B

2:45 PM-4:00 PM Viral Proteins: Regulation, Replication, Transcription 190 Inhibition of TCR Signaling Is Impaired in Nef Clones Derived From Elite Controllers StevenW. Jin 1 ;Tristan Markle 1 ; Asa Rahimi 1 ; Bruce D.Walker 2 ; Zabrina Brumme 1 ; Mark A. Brockman 1 1 SimonFraserUniv,Burnaby,BC,Canada; 2 Ragon InstofMGH,MIT,and Harvard,Cambridge,MA,USA 191 HIV-1 Nef Dimerization Is Important for AP2 Recruitment and CD4 Downregulation Sherry Shu ; Lori A. Emert-Sedlak;Thomas E. Smithgall UnivofPittsburgh,Pittsburgh,PA,USA 192 Quantification of HIV-1 Splicing Using a PrimerID- Tagged Deep Sequencing Assay Ann Emery ; Ronald I. Swanstrom UnivofNorthCarolinaatChapelHill,ChapelHill,NC,USA 193 Effects of Differential Cell Signaling in HIV Transcription Matthew J. Gagne 1 ;WilsonW.Wong 2 ; Gillian M. Schiralli Lester 3 ; Andrew Henderson 1 1 BostonUnivSchofMed,Boston,MA,USA; 2 BostonUniv,Boston,MA, USA; 3 UnivofRochesterMedCntr,Rochester,NY,USA 194 High-Frequency Illegitimate Strand-Transfers Result in Defective HIV Genomes Xiaojun Li 1 ; Peihu Fan1; Feng Gao 2 1 JilinUniv,Changchun,China; 2 HumanVaccine Inst,DukeUnivMedCntr, Durham,NC,USA 2:45 PM-4:00 PM Viral Proteins: Insights Into Structure 195 Gag-Protease-Mediated Replication Capacity Differs According to HIV-1 Subtype MarionW. Kiguoya 1 ; Jaclyn K. Mann 1 ; Saleha Omarjee 1 ; Lyle McKinnon 2 ; Festus M. Kiogora 2 ; Kamini Gounder 1 ; Blake Ball 3 ; Joshua Kimani 2 ;Thumbi P. Ndungu 1 1 UnivofKwaZulu-Natal,Durban,SouthAfrica; 2 UnivofNairobi,Nairobi, Kenya; 3 UnivofManitoba,Winnipeg,MB,Canada 196 Capsid Plays a Distinct Role in HIV Infection of TCR or TLR2-Activated CD4+ T Cells KimyataValere 1 ; Jian Ding 2 ;Theresa Chang 1 1 RutgersUniv,Newark,NJ,USA; 2 PHRsr Inst,Newark,NJ,USA 197 Consequences of p24 Gag Mutations for Capsid Stability and Viral Fitness Philipp Schommers 1 ; Gloria Martrus 2 ; Urte Matschl 2 ;Tom J. Hope 3 ; Gerd Fätkenheuer 1 ; Marcus Altfeld 2 Session P-A3 Poster Abstracts Hall A/B

Poster Listings

1 UnivofCologne,Cologne,Germany; 2 HeinrichPette Inst,Hamburg, Germany; 3 NorthwesternUniv,FeinbergSchofMed,Chicago, IL,USA

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CROI 2016