CROI 2016 Program at a Glance

Program and Agenda

340 Clonal Expansion of Replication-Competent Proviruses Is Common in Individuals on ART Michele D. Sobolewski 1 ; John K. Bui 1 ; Jonathan Spindler 2 ; Andrew Musick 3 ; Brandon Keele 4 ;Wei Shao 5 ; AnnWiegand 3 ; John M. Coffin 6 ; Mary F. Kearney 3 ; JohnW. Mellors 1 1 UnivofPittsburgh,Pittsburgh,PA,USA; 2 HIVDynamicsandReplication Prog,NatlCancer Inst,Frederick,MD,USA; 3 NCI,Frederick,MD,USA; 4 FrederickNatlLab,Frederick,MD,USA; 5 LeidosBiomedRsr, Inc,Frederick, MD,USA; 6 TuftsUniv,Boston,MA,USA 341 A Novel Assay to Quantify Replication-Competent Latent HIV-1 From rCD4+T Cells Phalguni Gupta 1 ; Anwesha Sanyal 1 ; Nicolas Sluis-Cremer 2 ; Deena Ratner 1 ; Ming Ding 1 ; Robbie B. Mailliard 2 ; Charles Rinaldo 2 ; Jennifer M. Zerbato 2 ; Amanda Chargin 3 ; Bruce K. Patterson 3 1 UnivofPittsburgh,GradSchofPH,Pittsburgh,PA,USA; 2 Univof Pittsburgh,Pittsburgh,PA,USA; 3 IncellDx, Inc,MenloPark,CA,USA 342 Cellular HIV-1 RNA/DNA As Biomarkers of Inducible Virion Production Anthony R. Cillo 1 ; Feiyu Hong 1 ; AngelaTsai 2 ; Alivelu Irrinki 2 ; Jasmine Kaur 2 ; Jacob Lalezari 3 ; Derek Sloan 2 ; Jeffrey P. Murry 2 ; JohnW. Mellors 1 1 UnivofPittsburgh,Pittsburgh,PA,USA; 2 GileadScis, Inc,FosterCity,CA, USA; 3 QuestClinicalRsr,SanFrancisco,CA,USA 2:45 PM-4:00 PM Tissue Reservoirs of HIV: Anatomic and Imaging Studies 343 FDG PET/CT Imaging of Lymph Nodes As a Measure of the HIV Reservoir in Humans Session P-F3 Poster Abstracts Hall A/B Priscilla Hsue 1 ; RichardTakx 2 ; Amorina Ishai 2 ; Irini Sereti 3 ; Remi Fromentin 4 ; Nicolas Chomont 4 ; Sophia Hur 1 ; Peter Ganz 1 ; Steven G. Deeks 1 ; AhmedTawakol 2 1 UnivofCaliforniaSanFrancisco,SanFrancisco,CA,USA; 2 Massachusetts GeneralHosp,Boston,MA,USA; 3 NIH,Bethesda,MD,USA; 4 Univof Montreal,Montreal,QC,Canada 344 Activation of Nasopharynx-Associated Lymphoid Tissue in HIV Infection Danny Li 1 ; RichardTakx 2 ; Amorina Ishai 2 ; Remi Fromentin 3 ; Irini Sereti 4 ; Nicolas Chomont 4 ; Sophia Hur 1 ; Steven G. Deeks 1 ; Priscilla Hsue 1 ; AhmedTawakol 2 1 UnivofCaliforniaSanFrancisco,SanFrancisco,CA,USA; 2 Massachusetts GeneralHosp,Boston,MA,USA; 3 UnivofMontreal,Montreal,QC,Canada; 4 NIH,Bethesda,MD,USA 345 HIV DNA Identified in Most Tissues of a Plasma- Negative HIV Autopsy Cohort Susanna L. Lamers 1 ; Rebecca Rose 1 ; David J. Nolan 2 ; Debra L. Garcia 3 ; Melissa Agsalda-Garcia 4 ; Bruce Shiramizu 4 ; Ekaterina Maidji 5 ; Cheryl Stoddart 5 ; Elyse Singer 6 ; Michael S. McGrath 5 1 Bioinfoexperts,LLC,Thibodaux,LA,USA; 2 EmergingPathogens Inst,Univ ofFlorida,Gainesville,FL,USA; 3 AIDSandCancerSpecimenResource,San Francisco,CA,USA; 4 UnivofHawaii,Honolulu,HI,USA; 5 UnivofCalifornia SanFrancisco,SanFrancisco,CA,USA; 6 NatlNeurologicalAIDSBank,Los Angeles,CA,USA

Session P-G1 Poster Abstracts

Hall A/B

2:45 PM-4:00 PM Neuroimaging: Brain Structure and Functional Response 381 Advanced MRI Predict Cognition at 1-Year Follow-up in Mildly Impaired HIV+ Patients Cristina Granziera 1 ; Gaetano Perrotta 2 ; Djalel Eddine Meskaldji 3 ; Guillaume Bonnier 3 ; Samanta Simioni 4 ; Matthias Cavassini 5 ; Melanie Metral 6 ; Gunnar Krueger 7 ; Renaud Du Pasquier 6 ; for the Swiss HIV Cohort Study 1 MassachusettsGeneralHosp,Boston,MA,USA; 2 HospErasme,Univ LibredeBruxelles,Bruxelles,Belgium; 3 ÉcolePolytechniqueFédéralede Lausanne,Lausanne,Switzerland; 4 InstdeLavigny,Lavigny,Switzerland; 5 UnivHospLausanne,UnivofLausanne,Lausanne,Switzerland; 6 CHUV, Lausanne,Switzerland; 7 Siemens,Renens,Switzerland 382 Topographies of Cortical and Subcortical Volume Loss in HIV and Aging in the cART Era Anika Guha 1 ; Matthew R. Brier 2 ; Beau M. Ances 2 ; Mario Ortega 1 ; ElizabethWesterhaus 1 ; Brittany Nelson 1 1 WashingtonUnivSchofMed,St.Louis,MO,USA; 2 WashingtonUniv inSt. Louis,St.Louis,MO,USA 383 Meta-Analysis of Large HIV Cohort Reveals CD4 Effects on Longitudinal Brain Atrophy Daniel Schonfeld 1 ;Talia M. Nir 1 ; Christopher R. Ching 2 ; Neda Jahanshad 3 ; Jaroslaw Harezlak 4 ; Giovanni Schifitto 5 ;Tong Zhu 6 ; Ronald A. Cohen 7 ; Bradford Navia 8 ; Paul M.Thompson 1 1 ImagingGeneticsCntr,UnivofSouthernCalifornia,MarinaDelRey, CA,USA; 2 UnivofCaliforniaLosAngelesSchofMed,MarinadelRey,CA, USA; 3 UnivofSouthernCalifornia,LosAngeles,CA,USA; 4 IndianaUniv FairbanksSchofPH, Indianapolis, IN,USA; 5 UnivofRochester,Rochester, NY,USA; 6 UnivofMichigan,AnnArbor,MI,USA; 7 UnivofFlorida, Gainesville,FL,USA; 8 TuftsUnivSchofMed,Boston,MA,USA 384 Brain Volumetric Changes After 2 Years of ART Initiated During Acute HIV Infection 1 UnivofHawaii,Honolulu,HI,USA; 2 SEARCH,Bangkok,Thailand; 3 Univ ofSouthernCalifornia,LosAngeles,CA,USA; 4 MilitaryHIVRsrProg, Bethesda,MD,USA; 5 UnivofCaliforniaSanFrancisco,SanFrancisco,CA, USA; 6 ThaiRedCrossAIDSRsrCntr,Bangkok,Thailand; 7 YaleUnivSchof Med,NewHaven,CT,USA 385 Regionally Specific Cortical Thinning in HIV+ Patients in the cART Era Ryan Sanford 1 ; Ana L. Fernandez Cruz 1 ; Lesley K. Fellows 1 ; Beau M. Ances 2 ; Louis Collins 1 1 McGillUniv,Montreal,QC,Canada; 2 WashingtonUniv inSt.Louis,St. Louis,MO,USA Kalpana J. Kallianpur 1 ; Donn Colby 2 ; Neda Jahanshad 3 ; James L. Fletcher 2 ; Jintanat Ananworanich 4 ; Katherine Clifford 5 ; Khunthalee Benjapornpong 6 ; Collin Adams 5 ; Serena S. Spudich 7 ;VictorValcour 5 ; for the RV254/SEARCH010 Study Group

Poster Listings

58

CROI 2016