CROI 2016 Program at a Glance

Program and Agenda

Session P-E1 Poster Abstracts

Hall A/B

308 Systematic Analysis of Glycan Heterogeneity Guides Rational Design of HIV Immunogens Wen-HanYu ; Monia Draghi; Claudia Arevalo; Peng Zhao; Douglas Lauffenburger; LanceWells; Galit Alter Ragon InstofMGH,MITandHarvard,Cambridge,MA,USA 309LB Optimal Combinations of bnAbs for Prevention and Treatment of HIV-1 Clade C Infection Michael Seaman 1 ; KshitijWagh 2 ;Tanmoy Bhattacharya Bhattacharya 2 ; CarolynWilliamson 3 ; Alex Robles 4 ; Madeleine Bayne 4 ; Jetta Garrity 4 ; Michael Rist 4 ; David Montefiori 5 ; Bette Korber 2 1 HarvardMedSchool,Boston,MA,USA; 2 TheoreticalDivision,LosAlamos NationalLaboratory,LosAlamos,NM,USA; 3 UnivofCapeTownand NationalHlthLaboratoryService,CapeTown,SouthAfrica; 4 Beth Israel DeaconessMedCntr,Boston,MA,USA; 5 DukeUniv,Durham,NC,USA 310LB Informatics-Based Improvement of HIV-1 Neutralizing Antibody 10E8 Peter D. Kwong 1 ;Young D. Kwon 2 ; Gwo-Yu Chuang 2 ; Baoshan Zhang 2 ; Tatyana Gindin 3 ; Krisha McKee 2 ; Sijy O’Dell 2 ; Mark Connors 4 ; Lawrence Shapiro 3 ; John R. Mascola 5 1 VaccineRsrCntr,NIAID/NIH,Bethesda,MD,USA; 2 VaccineRsrCntr,NIAID, NIH,Bethesda,MD,USA; 3 ColumbiaUniv,NewYork,NY,USA; 4 NIAID,NIH, Bethesda,MD,USA; 5 VRC,NIAID,NIH,Bethesda,MD,USA 311LB Effect of Infusion of Broadly Neutralizing Antibody VRC01 on HIV Plasma Rebound Tae-Wook Chun 1 ; Michael Sneller 2 ; Catherine Seamon 1 ; Jesse S. Justement 1 ; Mary E. Petrone 1 ; Eric Refsland 1 ; Julie Ledgerwood 3 ; Katherine Clarridge 1 ; Susan Moir 1 ; Anthony S. Fauci 1 1 NIAID,NIH,Bethesda,MD,USA; 2 NIH,Bethesda,MD,USA; 3 VRC,NIAID, NIH,Bethesda,MD,USA 2:45 PM-4:00 PM Cellular Immunity: Change to Cytotoxic T Lymphocyte and NK Cells 312 CD8 T Cells FromHIV Controllers Recognize and Kill HIV+ Non-Activated CD4 T Cells Blandine Monel 1 ; Julie Boucau 2 ;Yovana Pacheco 2 ; Annmarie McKeon 2 ; Daniel Kavanagh 2 ; Sylvie Le Gall 2 ; Bruce D.Walker 2 1 HowardHughesMed Inst/Ragon InstofMGH,MIT,andHarvard, Cambridge,MA,USA; 2 Ragon InstofMGH,MIT,andHarvard,Cambridge, MA,USA 313 HIV-1-Specific CD8 T Cells Are Poorly Cross-Reactive During Acute Infection Yimin Du 1 ; Anju Bansal 1 ; Jonathan Carlson 2 ; Jesus Salazar-Gonzalez 1 ; Kristin Ladell 3 ; Stephanie Gras 4 ; Sonya L. Heath 1 ; David Price 5 ; Jamie Rossjohn 4 ; Paul A. Goepfert 1 1 UnivofAlabamaatBirmingham,Birmingham,AL,USA; 2 MicrosoftRsr, Redmond,WA,USA; 3 CardiffUniv,Cardiff,UK; 4 MonashUniv,Clayton, Australia; 5 NIH,Bethesda,MD,USA Session P-E2 Poster Abstracts Hall A/B

2:45 PM-4:00 PM Antibody Responses to HIV Infection: What Drives Them and How They Affect the Virus 301 Oral PrEP Enhances Genital HIV-Neutralizing IgA in HIV-1 Exposed SeronegativeWomen Jennifer M. Lund 1 ; Kristina Broliden 2 ; Maria N. Pyra 3 ; Katherine K. Thomas 3 ; Deborah Donnell 4 ; Elizabeth Irungu 5 ;Timothy R. Muwonge 6 ; Nelly R. Mugo 5 ; Jared M. Baeten 3 ; Jairam R. Lingappa 3 1 FredHutchinsonCancerRsrCntr,Seattle,WA,USA; 2 KarolinskaUniv, Stockholm,Sweden; 3 UnivofWashington,Seattle,WA,USA; 4 SCHARP, FredHutchinsonCancerRsrCntr,Seattle,WA,USA; 5 KenyaMedRsr Inst, Thika,Kenya; 6 MakerereUnivCollofHlthScis,Kampala,Uganda 302 Potent Broadly Neutralising Antibody Responses in Slow-Progressing Pediatric HIV Emily Adland 1 ; Maximilian Muenchhoff 1 ; Anna Csala 1 ;Thumbi P. Ndungu 2 ; Pieter Jooste 3 ; Owen Karimanzira 4 ; Carol Crowther 4 ; Penny Moore 4 ; Lynn Morris 4 ; Philip Goulder 1 1 UnivofOxford,Oxford,UK; 2 UnivofKwaZulu-Natal,Durban,South Africa; 3 KimberleyHosp,Kimberley,SouthAfrica; 4 NCID, Johannesburg, SouthAfrica 303 Broadly Reactive Neutralizing Activity Within the First Six Months of HIV-1 Infection Amanda Fabra García 1 ; Nuria Gonzalez 2 ; Alberto Merino-Mansilla 3 ; Juan Ambrosioni 4 ; Anke Schultz 5 ; Jose M. Gatell 6 ; José Alcamí 2 ; José M. Miro 4 ; EloisaYuste 3 ;Victor Sanchez-Merino 3 1 IDIBAPS,Barcelona,Spain; 2 InstdeSaludCarlos III,Madrid,Spain; 3 Inst d InvestigacionsBiomèdiquesAugustPi iSunyer,Barcelona,Spain; 4 Hosp Clinic-IDIBAPS,UnivdeBarcelona,Barcelona,Spain; 5 Fraunhofer Inst forBiomedEngineering,St Ingbert,Germany; 6 HospClinicofBarcelona, Barcelona,Spain 304 New Family of Neutralizing Antibodies in HIV Asymptomatic Long-TermNonprogressors Patrice Debre 1 ;VincentVieillard 2 ; Olivier Lucar 2 ; Bin Su 3 ;Valérie Potard 4 ; Assia Samri 2 ; Christiane Moog 3 ; for the ANRS CO15 ALT Study Ggroup 1 INSERM,Paris,France; 2 INSERMU1135,Paris,France; 3 INSERMUMR S-1109,Strasbourg,France; 4 INSERMUMR-S1136,Paris,France 306 Neutralization Differences Between CCR5 and CXCR4 Tropic Viruses in HIV-1B Infection Ludy Registre ; Manish Sagar BostonUniv,Boston,MA,USA 307 Humoral Immune Pressure Selects for HIV-1 CXCR4- Using Variants Nina Lin 1 ; Oscar Gonzalez 1 ; Carlos Becerril 2 ; Behzad Etemad 2 ; Hong Lu 3 ; XuelingWu 3 ; Shahin Lockman 2 ; M. Essex 4 ; Daniel Kuritzkes 5 ; Manish Sagar 1 1 BostonUniv,Boston,MA,USA; 2 BrighamandWomen'sHosp,Harvard MedSch,Boston,MA,USA; 3 AaronDiamondAIDSRsrCntr,NewYork,NY, USA; 4 HarvardSchofPH,Boston,MA,USA; 5 HarvardMedSch,Boston, MA,USA WITHDRAWN 305

Poster Listings

56

CROI 2016