CROI 2016 Program at a Glance

Program and Agenda

10:30 143 Compartmentalized HIV DNA Populations Persist in CSF Despite Suppressive ART Michelli Faria de Oliveira ; Antoine Chaillon; Scott R. Letendre; Matt F. Strain; Ron Ellis; Sheldon R. Morris; Susan J. Little; Davey M. Smith; Sara Gianella UnivofCaliforniaSanDiego,SanDiego,CA,USA 10:45 144 Mitochondrial DNA Copy Number and Neurocognitive Impairment in HIV-Infected Persons 1 VanderbiltUnivSchofMed,Nashville,TN,USA; 2 ClevelandClinic/ LernerRsr Inst,Cleveland,OH,USA; 3 VanderbiltUniv,Nashville, TN,USA; 4 JohnsHopkinsUniv,Baltimore,MD,USA; 5 Univof CaliforniaSanDiego,SanDiego,CA,USA 11:00 145 Lipid Profiles and APOE4 Allele Impact Midlife Cognitive Decline in HIV+Men on ART Shibani S. Mukerji 1 ; Joseph Locascio 1 ;Vikas Misra 2 ; Lorenz David 2 ; Alexander Holman 3 ; Anupriya Dutta 2 ; Sudhir Penugonda 4 ; StevenWolinsky 4 ; Dana Gabuzda 2 1 MassachusettsGeneralHosp,Boston,MA,USA; 2 Dana-Farber Cancer Inst,Boston,MA,USA; 3 Dana-FarberCancer Inst, Brookline,MA,USA; 4 NorthwesternUniv,FeinbergSchofMed, Chicago, IL,USA 11:15 146 Paroxetine and Fluconazole Therapy for HAND: A Double-Blind, Placebo-Controlled Trial Ned Sacktor 1 ; Richard L. Skolasky 1 ; Norman Haughey 1 ; Cynthia Munro 1 ; Richard Moxley 1 ; Joseph Steiner 2 ; Avindra Nath 2 ; Justin McArthur 1 1 JohnsHopkinsUnivSchofMed,Baltimore,MD,USA; 2 NIH, Bethesda,MD,USA 11:30 147 MVC and TDF Reduce Neurocognitive Impairment in Initial ART: ACTG A5303 David Samuels 1 ; Asha R. Kallianpur 2 ;Yan Guo 3 ;ToddT. Brown 4 ; Sanjay R. Mehta 5 ; Ron Ellis 5 ; Scott R. Letendre 5 ;Todd Hulgan 3 ; for the CHARTER study group

Session O-13 Oral Abstracts

Ballroom B/C

10:00 AM-12:00 PM HCV: Curing the Patient but Not the Population Oral Abstract Moderators Arthur Y. Kim ,HarvardMedicalSchool,Boston,MA,USA Kristen M. Marks ,CornellUniversity,NewYork,NY,USA 10:00 149 Networks of HCV Transmissions Among Persons Who Inject Drugs: Indiana, 2015 Sumathi Ramachandran 1 ; EyasuTeshale 1 ;William Switzer 1 ; Philip Peters 1 ; Romeo R. Galang 1 ; Pamela Pontones 2 ; Jessica Gentry 2 ; Sara J. Blosser 2 ; JohnWard 1 ;Yury Khudyakov 1 ; for the HIV-HCVTransmission InvestigationTeam 1 CDC,Atlanta,GA,USA; 2 IndianaStateDeptofHlth, Indianapolis, IN,USA 10:15 150 Hepatitis B and C, Alcohol, and CD4 Drive End- Stage Liver Disease in HIV+ Adults Keri N. Althoff 1 ; Amy C. Justice 2 ; Joseph J. Eron 3 ; Lisa

Jacobson 4 ; Gregory D. Kirk 4 ; Marina B. Klein 5 ;Vincent Lo Re 6 ; Sonia Napravnik 3 ; Michael J. Silverberg 7 ; Richard Moore 4 1 JohnsHopkinsBloombergSchofPH,Baltimore,MD,USA; 2 Yale Univ,NewHaven,CT,USA; 3 UnivofNorthCarolinaatChapel

Hill,ChapelHill,NC,USA; 4 JohnsHopkinsUniv,Baltimore, MD,USA; 5 McGillUnivHlthCntr,Montreal,QC,Canada; 6 Univ ofPennsylvania,Philadelphia,PA,USA; 7 KaiserPermanente NorthernCalifornia,Oakland,CA,USA 10:30 151 Antiretroviral Therapy Reduces Intrahepatic Hepatitis C in HIV-1/HCV Coinfection Jeffrey Quinn 1 ; Abraham J. Kandathil 1 ; Jennifer Shellenberger 1 ;

Thursday, February 25, 2016 • Oral Sessions

Ramy El-Diwany 1 ; Merve Gurakar 2 ; Mark Sulkowski 1 ; Ruy M. Ribeiro 3 ; Alan S. Perelson 3 ; David L.Thomas 4 ; Ashwin Balagopal 1 1 JohnsHopkinsUniv,Baltimore,MD,USA; 2 Virginia CommonwealthUniv,Richmond,VA,USA; 3 LosAlamosNatlLab, LosAlamos,NM,USA; 4 JohnsHopkinsUnivSchofMed,Baltimore, MD,USA ReInfection or Subsequent Chronic Infection Sabrina J. Merat 1 ; Richard Molenkamp 2 ; Dorien van de Berg 1 ; Camille Bru 1 ; Sylvie M. Koekkoek 2 ; Neeltje A. Kootstra 2 ; Maria

Kevin R. Robertson 1 ; Sachiko Miyahara 2 ; Anthony Lee 2 ;Todd T. Brown 3 ; Ellen S. Chan 2 ; Baiba Berzins 4 ; David Rusin 5 ; Joseph J. Eron 1 ; BabafemiTaiwo 6 ; for the AIDS ClinicalTrials GroupTeam 5303 1 UnivofNorthCarolinaatChapelHill,ChapelHill,NC,USA; 2 HarvardUniv,Boston,MA,USA; 3 JohnsHopkinsUniv,Baltimore, MD,USA; 4 NorthwesternUniv,Chicago, IL,USA; 5 FrontierSci &TechRsrFndn, Inc,Amherst,NY,USA; 6 FeinbergSchofMed, NorthwesternUniv,Chicago, IL,USA

10:45 152 Broadly Neutralizing Antibodies Avert HCV

Prins 3 ; Arjen Q. Bakker 1 ;Tim Beaumont 1 ; Janke Schinkel 2 1 AIMMTherapeutics,Amsterdam,Netherlands; 2 Academic MedCntr,Amsterdam,Netherlands; 3 PHServiceofAmsterdam, Amsterdam,Netherlands 11:00 153 High Response Rate in HCV-Genotype 4 Patients TreatedWith Ravidasvir and Sofosbuvir

11:45 148 Brain MRI Changes AssociatedWith Poorer Cognitive Function in Treated HIV Infection Jonathan Underwood 1 ; James H. Cole 1 ; MatthanW. Caan 2 ; David J. Sharp 1 ; Davide De Francesco 3 ; Robert Leech 1 ; Caroline Sabin 3 ; Charles B. Majoie 2 ; Peter Reiss 4 ; AlanWinston 5 ; for the The Co-morBidity in Relation to Aids (COBRA) Collaboration

Gamal Esmat 1 ; Maissa El Raziky 2 ; Asmaa Gomaa 3 ;Tamer Elbaz 4 ; Mahmoud Abouelkhair 2 ; Alyaa Sabry 3 ; Hadeel Gamal Eldeen 4 ; Mohammed Karim 2 ; Mohammed Abdel-Hamid 5 ; Ola Nada 5 ; Sherine Helmy 6 ; Hanaa Abdel-Maguid 6 ; Richard Colonno 7 ; Nathaniel Brown 7 ; Eric Ruby 7 ; PamelaVig 7 ; ImamWaked 3 1 CairoUniv,Cairo,Egypt; 2 CairoFatemicHosp,Cairo,Egypt; 3 Natl Liver Inst,ShebeenElKom,Egypt; 4 KasrAlainiViralHepatitis Cntr,Cairo,Egypt; 5 MyLabLab,Cairo,Egypt; 6 EuropeanEgyptian Pharmaceutical Industries,Alexandria,Egypt; 7 Presidio Pharmaceuticals,SanFrancisco,CA,USA

1 ImperialCollLondon,London,UK; 2 AcademicMedCntr, Amsterdam,Netherlands; 3 UnivCollLondon,London,UK; 4 Amsterdam Inst forGlobalHlthandDevelop,Amsterdam, Netherlands; 5 ImperialCollofSci,TechandMed,London,UK

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CROI 2016