CROI 2016 Program at a Glance

Program and Agenda

THURSDAY, FEBRUARY 25, 2016 Thursday Plenary Session Auditorium 8:30 AM-9:30 AM 8:30 131 Tuberculosis: Why Do I Have to Take So Many Pills? Eric J. Rubin ,HarvardSchoolofPublic Health,Boston,MA,USA CME

11:00 137 The PPIP122-125 Motif in HIV-1 CA Is an Essential Assembly and Maturation Element

Mariia Novikova 1 ; Muthukumar Balasubramaniam 1 ; Sagar Kudchodkar 1 ; Ferri Soheilian 2 ; AnnaT. Gres 3 ; Karen A. Kirby 4 ; Stefan G. Sarafianos 3 ; Eric O. Freed 1

1 NCI,Frederick,MD,USA; 2 LeidosBiomedRsr, Inc,Frederick,MD, USA; 3 UnivofMissouri,Columbia,MO,USA; 4 UnivofMissouriSch ofMed,Columbia,MO,USA 11:15 138 Characterization of 2 CCR5 Tropic HIV-1 Viruses Exhibiting High Env Content Sean P. O’Brien 1 ;Terra M. Ireland 1 ; JulianW. Bess 1 ; James D. Roser 1 ; Elena N. Chertova 1 ; Gregory Q. Del Prete 2 ; Brandon Keele 2 ; Jeffrey Lifson 2 1 LeidosBiomedRsr, Inc,Frederick,MD,USA; 2 FrederickNatlLab, Frederick,MD,USA 11:30 139 Nuclear Entry of HIV Requires Reshaping of Integrase Multimers Frauke Christ 1 ; Lieve Dirix 2 ; Doortje Borrenberghs 2 ; Flore De Wit 1 ; Jolien Blokken 1 ; Susana Rocha 1 ; Jelle Hendrix 2 ; Zeger Debyser 1 ; Johan Hofkens 2 1 KatholiekeUniversiteitLeuven,Leuven,Belgium; 2 Katholieke UniversiteitLeuven,Heverlee,Belgium 11:45 140 1970s HIV-1 Genomes Reveal the Early History of the North American HIV/AIDS Epidemic 10:00 AM-12:00 PM Central Nervous System: Viral Dynamics, Biomarkers, and Cognition Oral Abstract Moderators Paola Cinque ,SanRaffaeleScientific Institute,Milano, Italy Renaud Du Pasquier ,CentreHospitalierUniversitaireVaudois,Lausanne, Switzerland 10:00 141 SIV-Infected Brain Macrophages Leave the Central Nervous System Xavier Alvarez 1 ; Cecily Midkiff 1 ; Andrew Lackner 1 ; Kenneth C. Williams 2 1 TulaneNatlPrimateRsrCntr,Covington,LA,USA; 2 BostonColl, ChestnutHill,MA,USA 10:15 142 CSF Lymphocyte and Monocyte Activation and Trafficking in Primary HIV Infection Xiang Li 1 ; Fangyong Li 2 ; AnjiYi 2 ; Julia Peterson 3 ; Brinda Emu 1 ; MichaelWorobey 1 ;Thomas D.Watts 1 ; Richard A. McKay 2 ; Timothy Granade 3 ; Beryl A. Koblin 4 ;Walid Heneine 3 ; HaroldW. Jaffe 3 1 UnivofArizona,Tucson,AZ,USA; 2 UnivofCambridge, Cambridge,UK; 3 CDC,Atlanta,GA,USA; 4 NewYorkBloodCntr, NewYork,NY,USA Session O-12 Oral Abstracts

9:00 132 The Evolving Epidemiology of HIV Infection in Persons Who Inject Drugs: Indiana 2015 JohnT. Brooks ,Centers forDiseaseControl andPrevention,Atlanta,GA,USA

Session O-11 Oral Abstracts

Room 312

10:00 AM-12:00 PM HIV Virology: Putting It All Together Oral Abstract Moderators Javier Martinez-Picado , IrsiCaixa Institute forAIDSResearch, Badalona,Spain Manish Sagar ,BostonUniversity,Boston,MA,USA 10:00 133 Type 1 Interferon Resistance Is a Hallmark of Mucosally Transmitted HIV-1 Frederic Bibollet-Ruche 1 ; Shilpa Iyer 1 ; Ronnie Russell 1 ; Andrew G. Smith 1 ; Christiana M. Shaw 1 ;Yingying Li 1 ;Timothy Decker 1 ; George M. Shaw 2 ; Persephone Borrow 3 ; Beatrice Hahn 1 1 UnivofPennsylvania,Philadelphia,PA,USA; 2 PerelmanSch ofMed,UnivofPennsylvania,Philadelphia,PA,USA; 3 Univof Oxford,Oxford,UK 10:15 134 Expression and Potency of IFNa Subtypes in an Ex Vivo Model of Acute HIV-1 Infection

Room 304/306

Mario L. Santiago 1 ; Michael S. Harper 1 ; Kejun Guo 1 ; Kathrin Gibbert 2 ; Eric L. Lee 1 ; Stephanie M. Dillon 1 ; Martin D. McCarter 1 ; Kim J. Hasenkrug 3 ; Ulf Dittmer 2 ; CaraWilson 4

Oral Sessions • Thursday, February 25, 2016

1 UnivofColoradoAnschutzMedCampus,Aurora,CO,USA; 2 Univ ofDuisburg-Essen,Essen,Germany; 3 NIAID,NIH,Hamilton,MT, USA; 4 UnivofColoradoHosp,Aurora,Aurora,CO,USA 10:30 135 Novel Mechanism of Interferon Restriction of HIV-1 in Humans

Ramy El-Diwany 1 ; Michael Chattergoon 1 ; Justin R. Bailey 1 ; Stuart C. Ray 1 ; Sarah J.Wheelan 1 ; Joel N. Blankson 2 ; Robert Siliciano 3 ; David L.Thomas 2 ; Ashwin Balagopal 1

1 JohnsHopkinsUniv,Baltimore,MD,USA; 2 JohnsHopkinsUniv SchofMed,Baltimore,MD,USA; 3 HowardHughesMed Inst, Baltimore,MD,USA 10:45 136 SERINC3 and SERINC5 Are Novel Antiviral Proteins Antagonized by HIV-1 Nef

RichardW. Price 3 ; Elizabeth Sinclair 3 ; Serena S. Spudich 1 1 YaleUnivSchofMed,NewHaven,CT,USA; 2 YaleUnivSchof PH,NewHaven,CT,USA; 3 UnivofCaliforniaSanFrancisco,San Francisco,CA,USA

YuanfeiWu ;Yoshiko Usami; Heinrich G. Gottlinger UnivofMassachusettsMedSch,Worcester,MA,USA

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CROI 2016