CROI 2015 Program and Abstracts

Poster Listings

767 Tenofovir Replacement in Patients With Osteoporosis Increased Sclerostin Levels Eugenia Negredo 3 ; Adolfo Díez-Pérez 2 ; Pere Domingo 4 ; Nuria Pérez-Álvarez 6 ; Mar Gutierrez 4 ; Gracia Mateo 4 ; Jordi Puig 1 ; Patricia Echeverria 1 ; Anna Bonjoch 1 ; Bonaventura Clotet 5 1 Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain; 2 Hospital del Mar-IMIM, Universitat Autònoma de Barcelona and RETICEF, Instituto Carlos III Madrid, Barcelona, Spain; 3 Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Universitat de Vic–Universitat Central de Catalunya, Barcelona, Spain; 4 Santa Creu i Sant Pau Hospital, Universitat Autònoma de Barcelona, Barcelona, Spain; 5 Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Irsicaixa Foundation, Germans Trias i Pujol University Hospital, Barcelona, Spain; 6 Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Universitat Autònoma de Barcelona, Statistics and Operations Research Department, Universitat Politècnica de Catalunya, Barcelona, Spain 768 Relationship Between Phosphate Reabsorption, Age, Tenofovir and Bone Mineral Density Lisa Hamzah 2 ; Amanda Samarawickrama 1 ; KarenWalker-Bone 3 ;Yvonne Gilleece 4 ; Martin Fisher 1 ; Frank A. Post 5 1 Brighton and Sussex Medical School, London, United Kingdom; 2 King’s College London, London, United Kingdom; 3 University of Southampton, Southampton, United Kingdom; 4 Brighton and Sussex Hospitals NHS Trust, Brighton, United Kingdom; 5 King’s College Hospital NHS Foundation Trust, London, United Kingdom 769LB Less Bone Loss With a Maraviroc Regimen in HIV-Infected Treatment- Naïve Subjects Babafemi Taiwo 1 ; Ellen Chan 2 ; Carl Fichtenbaum 3 ; Heather Ribaudo 2 ; AtheTsibris 4 ; Karin Klingman 5 ; Joseph J. Eron 6 ; Baiba Berzins 1 ;ToddT. Brown 7 ACTG A5303 StudyTeam 1 Northwestern University, Feinberg School of Medicine, Chicago, IL, US; 2 Statistical and Data Analysis Center, Harvard School of Public Health, Boston, MA, US; 3 University of Cincinnati, Cincinnati, OH, US; 4 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US; 5 National Institutes of Health, Bethesda, MD, US; 6 University of North Carolina at Chapel Hill, Chapel Hill, NC, US; 7 Johns Hopkins University School of Medicine, Baltimore, MD, US 2:30 pm– 4:00 pm Bone Disease: Mechanisms of Bone Loss and Fracture Risk 770 Association of Adipokines With Bone Mineral Density in HIV+ and HIV- Women Anjali Sharma 1 ;Yifei Ma 2 ; Rebecca Scherzer 2 ; Amber L.Wheeler 2 ; Mardge Cohen 3 ; Deborah Gustafson 4 ; MichaelTYin 5 ; Phyllis C.Tien 2 1 Albert Einstein College of Medicine, Bronx, NY, US; 2 University of California San Francisco, San Francisco, CA, US; 3 John H. Stroger Jr. Hospital of Cook County, Chicago, IL, US; 4 State University of New York Downstate Medical Center, Brooklyn, NY, US; 5 College of Physicians and Surgeons, Columbia University, New York, NY, US 771 Long-Term Changes in Bone Mineral Density and Insulin Resistance on Statins in HIV Kristine M. Erlandson 1 ;Ying Jiang 2 ; Sara M. Debanne 2 ; Grace A. McComsey 2 1 University of Colorado, Aurora, CO, US; 2 Case Western Reserve University, Cleveland, OH, US 772 Immunologic Predictors of Bone Loss in a Contemporary HIV Cohort Edgar T. Overton 1 ; Katherine H. Hullsiek 2 ; Gerome Escota 3 ; Kenneth A. Lichtenstein 4 ; Lois Conley 5 ; Pragna Patel 5 ; JohnT. Brooks 5 ; Irini Sereti 6 ; JasonV. Baker 2 the CDC SUN (Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy) Investigators 1 University of Alabama at Birmingham, Birmingham, AL, US; 2 University of Minnesota, Minneapolis, MN, US; 3 Washington University School of Medicine, St. Louis, MO, US; 4 National Jewish Health, Denver, CO, US; 5 Division of HIV/AIDS Prevention, Atlanta, GA, US; 6 National Institute of Allergy and Infectious Disease (NIAID), Bethesda, MD, US Session P-Q3 Poster Session Poster Hall

773 RANKL Predicts 96-Week BMD Changes in ATV/r Monotherapy: A MODAt Trial Sub-Study Vincenzo Spagnuolo 1 ; Marco Borderi 2 ; Giuseppina Musumeci 2 ; Laura Galli 1 ; Camilla Tincati 3 ; Stefano Rusconi 3 ; Giovanni Guaraldi 4 ; Alba Bigoloni 1 ; Adriano Lazzarin 1 ; Antonella Castagna 1 1 San Raffaele Scientific Institute, Milan, Italy; 2 Alma Mater Studiorum University of Bologna, Bologna, Italy; 3 University of Milan, Milan, Italy; 4 University of Modena and Reggio Emilia, Modena, Italy 774 Predictors of Longitudinal Change in Bone Mineral Density in a Cohort of HIV Positive and Negative Subjects Willard Tinago 1 ; Aoife Cotter 1 ; Caroline Sabin 2 ; Alan Macken 1 ; Eoin Kavanagh 3 ; Jennifer Brady 4 ; Geraldine McCarthy 5 ; Juliet Compston 6 ; PatrickW. Mallon 1 HIV UPBEAT Study Group 1 University College Dublin, Dublin, Ireland; 2 Research Department of Infection and Poulation Health, London, United Kingdom; 3 Mater Misericordiae University Hospital, Dublin, Ireland; 4 Mater Misericordiae University Hospital, Dublin, Ireland; 5 Mater Misericordiae University Hospital, Dublin, Ireland; 6 University of Cambridge, London, United Kingdom Anjali Sharma 1 ; Qiuhu Shi 2 ; Donald R. Hoover 3 ; Kathryn Anastos 1 ; Phyllis C.Tien 4 ; Mary A. Young 5 ; Mardge Cohen 6 ; Deborah Gustafson 7 ; MichaelTYin 8 1 Albert Einstein College of Medicine, Bronx, NY, US; 2 New York Medical College, Valhalla, NY, US; 3 Rutgers University, Piscataway, NJ, US; 4 University of California San Francisco, San Francisco, CA, US; 5 Georgetown University, Washington D.C., DC, US; 6 John H. Stroger Jr. Hospital of Cook County, Chicago, IL, US; 7 State University of New York Downstate Medical Center, Brooklyn, NY, US; 8 College of Physicians and Surgeons, Columbia University, New York, NY, US 2:30 pm– 4:00 pm Measuring Bone Density 776 Heel Quantitative Ultrasound to Cut Down on DXA Costs in HIV-infected Patients Marilia R. Pinzone ; Maria Gussio; Daniela Castronuovo; Adriana Di Gregorio; Benedetto M. Celesia; Bruno Cacopardo; Giuseppe Nunnari University of Catania, Catania, Italy 777 Novel Radiographic Measures HRpQCT and HSA as Correlates of HIV- Associated Fractures Darrell H. Tan 1 ; Janet Raboud 2 ; Leah Szadkowski 2 ; Eva Szabo 4 ; Hanxian Hu 4 ; Queenie Wong 4 ; Angela Cheung 4 ; SharonWalmsley 3 1 St. Michael’s Hospital, Toronto, Canada; 2 Toronto General Research Institute, Toronto, Canada; 3 University Health Network, Toronto, Canada; 4 Centre for Excellence in Skeletal Health Assessment, Toronto, Canada Session P-Q4 Poster Session Poster Hall 2:30 pm– 4:00 pm Fat Without Borders: Metabolic Complications in Resource- Limited Settings 778 Obesity and Inflammation in Resource-Diverse Settings of ART Initiation Kristine M. Erlandson 1 ; Nikhil Gupte 2 ; Javier R. Lama 3 ; Patcharaphan Sugandhavesa 4 ; Thando Mwelase 5 ; Ashwin Balagopal 2 ; David Asmuth 6 ;Thomas B. Campbell 1 ; Amita Gupta 2 On behalf of the A5175 and NWCS319 study team 1 University of Colorado, Aurora, CO, US; 2 Johns Hopkins University, Baltimore, MD, US; 3 Impacta Peru Clinical Trials Unit, Lima, Peru; 4 Chiang Mai University, Chiang Mai, Thailand; 5 University of Witswatersrand, Johannesburg, South Africa; 6 University of California Davis, Sacramento, CA, US 775 Fracture Incidence Is Increased in Aging HIV-InfectedWomen WEDNESDAY, FEBRUARY 25, 2015 Session P-Q5 Poster Session Poster Hall

Poster Listings

60

CROI 2015