CROI 2015 Program and Abstracts

Poster Listings

472 Performance of 4 Tools to Screen for HIV-Associated Cognitive Impairment

480 CD14+ PBMC Secrete Cytokines Linked to HIV-Associated Neurocognitive Disorders Melissa A. Agsalda-Garcia 4 ;Victor G.Valcour 1 ; Pasiri Sithinamsuwan 2 ; Guangxiang G. Zhang 4 ; Cecilia M. Shikuma 4 ; James L. Fletcher 3 ; Nicholas Hutchings 1 ; Alexandra Schuetz 5 ; Jintanat Ananworanich 3 ; Bruce Shiramizu 4 1 University of California San Francisco, San Francisco, CA, US; 2 Phramongkutklao Hospital, Bangkok, Thailand; 3 The Thai Red Cross AIDS Research Centre, Bangkok, Thailand; 4 University of Hawaii, John A. Burns School of Medicine, Honolulu, HI, US; 5 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 481 MBL-HIV1gp120 Immunoreactivity Is AssociatedWith Markers of Neuronal Injury Carmen Teodorof 1 ; Damhnien Nguyen 1 ; Nishi Kadakia 1 ; Ricky Maung 2 ; Benchawanna Soontornniyomkij 1 ; Cristian Achim 1 ; David Moore 1 ; Eliezer Masliah 1 ; Marcus Kaul 2 ; Kumud Singh 1 1 University of California San Diego, San Diego, CA, US; 2 The Sanford BurnhamMedical Research Institute, La Jolla, CA, US 2:30 pm– 4:00 pm Aging and Cognitive Decline 482 Amyloid Uptake by PET Imaging in Older HIV+ Individuals With Cognitive Impairment Ned Sacktor ; Richard Skolasky; Heidi Roosa;Yun Zhou;WeiguoYe; Noble George; Dean Wong; Mona Mohamed Johns Hopkins University School of Medicine, Baltimore, MD, US 483 Lower CSF Amyloid- β Levels Are AssociatedWithWorse Neurocognitive Functioning in HIV-Infected Adults With a Family History of Dementia Pariya L. Fazeli 1 ; David J. Moore 1 ; Donald Franklin 1 ; Robert Heaton 1 ; Christina Marra 2 ; Benjamin B. Gelman 3 ; Allen McCutchan 1 ; Igor Grant 1 ; Scott Letendre 1 1 University of California San Diego, San Diego, CA, US; 2 University of Washington Seattle, Seattle, WA, US; 3 University of Texas Medical Branch, Galveston, TX, US 484 Cystatin C Is AssociatedWith Neurocognitive Impairment in Older HIV+ Adults Marissa Sakoda 1 ; Pariya L. Fazeli 2 ; Scott Letendre 2 ; Dilip Jeste 2 ; Igor Grant 2 ; David J. Moore 2 1 John A. Burns School of Medicine at the University of Hawaii, Honolulu, HI, US; 2 University of California San Diego, San Diego, CA, US 485 Leptomeningeal Enhancement on MRI in the Aging HIV-Positive Population Bryan R. Smith 1 ; Sally Steinbach 1 ; Govind Nair 1 ; Caryn Morse 1 ; Joseph Snow 2 ; Suad Kapetanovick 2 ; Henry Masur 1 ; Avindra Nath 1 ; Daniel S. Reich 1 1 National Institutes of Health, Bethesda, MD, US; 2 National Institute of Mental Health, Bethesda, MD, US; 3 National Institutes of Health, Clinical Center, Bethesda, MD, US 486 Hepatitis C Infection and Cognition in Older HIV+ Adults: Data From the Center of Excellence on Disparities in HIV and Aging (CEDHA) Oluwatoyin M. Adeyemi 1 ; Sue Leurgans 2 ; Alan Landay 2 ; David Bennett 2 ; Lisa Barnes 2 1 Ruth M Rothstein CORE Center, Cook County Health and Hospitals System, Chicago, IL, US; 2 Rush University Medical Center, Chicago, IL, US 487 Neurocognitive Screening Tests Are AssociatedWith Cardiovascular Risk and VACS Scores Andrea Calcagno 1 ; Marielisabetta Scarvaglieri 1 ; DanielaVai 2 ; Alessandro Livelli 2 ; Letizia Marinaro 1 ; Giancarlo Orofino 2 ; Nicole Pagani 1 ; Daniele Imperiale 2 ; Giovanni Di Perri 1 ; Stefano Bonora 1 1 University of Torino, Torino, Italy; 2 ASLTO2, Torino, Italy; 3 ASLTO2, Torino, Italy 488 Aerobic Exercise Attenuates Cognitive Decline and Brain Volume Loss AssociatedWith HIV Brian Basco 1 ; Mario Ortega 1 ; Jodi M. Heaps 3 ; Laurie Baker 2 ; FlorinVaida 4 ; Beau Ances 1 1 Washington University School of Medicine, St. Louis, MO, US; 2 University of Missouri St. Louis, St. Louis, MO, US; 3 Missouri Institute of Mental Health, St. Louis, MO, US; 4 University of California San Diego, San Diego, CA, US WEDNESDAY, FEBRUARY 25, 2015 Session P-G7 Poster Session Poster Hall

Judith Schouten 2 ;Tanja Su 2 ; Rosan A. van Zoest 1 ; FerdinandW.Wit 1 ; Ineke G. Stolte 5 ; Alan Winston 3 ; Peter Reiss 1 ; Peter Portegies 4 ; Gert J. Geurtsen 2 ; Ben A. Schmand 2 1 Amsterdam Institute for Global Health and Development, Amsterdam, Netherlands; 2 Academic Medical Center University of Amsterdam, Amsterdam, Netherlands; 3 Imperial College London, London, Netherlands; 4 Onze Lieve Vrouwe Gasthuis, Amsterdam, Netherlands; 5 Public Health Service of Amsterdam, Amsterdam, Netherlands

THURSDAY, FEBRUARY 26, 2015 Session P-G6 Poster Session

Poster Hall

2:30 pm– 4:00 pm Inflammation and Markers of Brain Injury in HAND 473 Astrocyte and Microglial Activation in Acute and Chronic HIV Pre- and Post-cART Michael Peluso 1 ;Victor G.Valcour 2 ; Jintanat Ananworanich 3 ; James L. Fletcher 4 ; Somporn Tipsuk 4 ; Bonnie Slike 3 ; Nittaya Phanuphak 4 ; Magnus Gisslén 5 ; Henrik Zetterberg 5 ; Serena Spudich 6 RV254/SEARCH 010 & SEARCH 011 StudyTeams 1 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US; 2 University of California San Francisco, San Francisco, CA, US; 3 Walter Reed Army Institute of Research, Bethesda, MD, US; 4 Thai Red Cross AIDS Research Centre, Bangkok, Thailand; 5 University of Gothenburg, Gothenburg, Sweden; 6 Yale University, New Haven, CT, US 474 CNS Immunoactivation and Neuronal Damage in Patients With Progressive Neurocognitive Impairment Arvid Edén 1 ; Donald Franklin 2 ; Henrik Zetterberg 1 ; Dietmar Fuchs 3 ; Robert Heaton 2 ; Scott Letendre 2 ;Thomas Marcotte 2 ; Richard Price 4 ; Igor Grant 2 ; Magnus Gisslén 1 1 University of Gothenburg, Gothenburg, Sweden; 2 University of California San Diego, San Diego, CA, US; 3 Innsbruck Medical University, Innsbruck, Austria; 4 University of California San Francisco, San Francisco, CA, US 475 Endothelial Function and CNS Measures in Primary HIV Infection Pre and Post Early ART Sebastian Urday 1 ; Zaina Zayyad 1 ; Julia Peterson 2 ; Felicia C. Chow 2 ; Kevin R. Robertson 3 ; Richard Price 2 ; Priscilla Hsue 2 ; Serena Spudich 1 1 Yale University, New Haven, CT, US; 2 University of California San Francisco, San Francisco, CA, US; 3 University of North Carolina, Chapel Hill, NC, US 476 Platelet-Endothelial Interactions in SIV-Associated CNS Disease Claire E. Lyons 2 ; Hannah Schneider 3 ; Liz Engle 1 ; Suzanne E. Queen 1 ; Craig N. Morrell 4 ; Joseph L. Mankowski 1 ; Kelly A. Pate 1 1 Johns Hopkins University School of Medicine, Baltimore, MD, US; 2 Tufts University, North Grafton, MA, US; 3 Colorado State University, Fort Collins, CO, US; 4 University of Rochester, Rochester, NY, US 477 Microbial Translocation Is AssociatedWith Neuroinflammation in HIV Subjects on ART Jaime H. Vera 1 ; Qi Guo 2 ; Adriano Boasso 1 ; Louise Greathead 1 ; James Cole 1 ; Courtney Bishop 2 ; Rabiner Ilan 2 ; Roger Gunn 2 ; Paul Matthews 1 ; AlanWinston 1 1 Imperial College London, London, United Kingdom; 2 Imanova Centre for Imaging Sciences, London, United Kingdom 478 DKK1 Is AssociatedWith HIV-Associated Neurocognitive Impairment ChunjiangYu 1 ; Melanie Seaton 1 ; Scott Letendre 2 ; Robert Heaton 2 ; Lena Al-Harthi 1 1 Rush University Medical Center, Chicago, IL, US; 2 University of California at San Diego, San Diego, CA, US 479 Markers of HIV-Associated Cognitive Impairment Are Elevated in HIV- Infected Patients With Neurosyphilis Emily Ho ; LaurenTantalo; Sharon Sahi;Trudy Jones; Shelia Dunaway; Christina Marra University of Washington, Seattle, WA, US

Poster Listings

41

CROI 2015