CROI 2015 Program and Abstracts

Poster Listings

457 Peripheral Neuropathy at First-Line Failure and on Second Line in Sub- Saharan Africa Alejandro Arenas-Pinto 1 ; JenniferThompson 1 ; Godfrey Musoro 4 ; Helen Mussana 5 ; Abbas Lugemwa 3 ; Andrew D. Kambugu 2 ; Aggrey Mweemba 6 ; SarahWalker 1 ; Paton Nicholas 1 On behalf of the EARNESTTrialTeam 1 University College London, London, United Kingdom; 2 Makerere University, Kampala, Uganda; 3 Joint Clinical Research Centre, Mbarara, Uganda; 4 University of Zimbabwe, Harare, Zimbabwe; 5 Joint Clinical Research Centre, Kampala, Uganda; 6 University Teaching Hospital, Lusaka, Zambia 458 Prevalence of and Risk Factors for Peripheral Neuropathy in Rakai, Uganda Deanna R. Saylor 1 ; Gertrude Nakigozi 2 ; Noeline Nakasujja 3 ; Xiangrong Kong 4 ; Kevin Robertson 5 ; Ronald H. Gray 4 ; Maria J.Wawer 4 ; Ned Sacktor 1 1 Johns Hopkins School of Medicine, Baltimore, MD, US; 2 Rakai Health Sciences Program, Entebbe, Uganda; 3 Makerere University College of Health Sciences, Kampala, Uganda; 4 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 5 University of North Carolina, Chapel Hill, NC, US 459 Predictors of Cognitive Performance Among HIV-Infected Patients in East Africa Victor G. Valcour 1 ; Francis Kiweewa 2 ; Rosemary Namagembe 2 ; Rither Langat 3 ; Samoel Khamadi 4 ; Kyra Hansson 1 ; Christina S. Polyak 5 ; Julie Ake 5 On behalf of the RV329 AFRICOS StudyTeam 1 University of California San Francisco, San Francisco, CA, US; 2 Walter Reed Project, Kampala, Uganda; 3 Walter Reed Project, Kericho, Kenya; 4 Walter Reed Project - Tanzania, Mbeya, United Republic of Tanzania; 5 Walter Reed Army Institute of Research, Silver Spring, MD, US 2:30 pm– 4:00 pm HAND Genetics 460 Mitochondrial DNA Haplogroups and CSF Neuroinflammation in the CHARTER Cohort Todd Hulgan 4 ; David Samuels 4 ; Ronald J. Ellis 1 ;William Bush 2 ; Scott Letendre 1 ; Donald Franklin 1 ; Igor Grant 1 ; Asha R. Kallianpur 3 CHARTER Group 1 University of California San Diego, San Diego, CA, US; 2 Case Western Reserve University, Cleveland, OH, US; 3 Cleveland Clinic Foundation, Lerner Research Institute, Cleveland, OH, US; 4 Vanderbilt University, Nashville, TN, US 461 Iron-Regulatory Genes Are AssociatedWith Neuroimaging Traits in HIV Infection Tricia A.Thornton-Wells 2 ; Christine Fennema-Notestine 3 ;Todd Hulgan 4 ; Scott Letendre 5 ; Ronald J. Ellis 6 ; Asha R. Kallianpur 1 ; for the CHARTER Group 7 1 Cleveland Clinic/Lerner Research Institute, Cleveland, OH, US; 2 Vanderbilt University School of Medicine, Nashville, TN, US; 3 University of California San Diego, San Diego, CA, US; 4 Vanderbilt University School of Medicine, Nashville, TN, US; 5 University of California San Diego, San Diego, CA, US; 6 University of California San Diego, San Diego, CA, US; 7 University of California San Diego (UCSD), San Diego, CA, US 462 Synergistic Effects of MBL2 / APP Polymorphisms on Neurocognitive Impairment in CHARTER Kumud Singh ; Qianqian Deng; Christine Fennema-Notestine; FlorinVaida; Ronald Ellis; Scott Letendre; Donald Franklin; Debralee Rosario; Robert Heaton; Igor Grant CHARTER University of California San Diego, La Jolla, CA, US 463 No Association Between Apo ε 4 , HIV Infection, Age, Cognitive Outcome or Death James T. Becker 1 ; Jeremy J. Martinson 1 ; Sudhir Penugonda 2 ; Lawrence Kingsley 1 ; Samantha A. Molsberry 1 ; Sandra Reynolds 3 ; Andrew Levine 4 ; Eileen Martin 5 ; Cynthia A. Munro 6 ; Ned Sacktor 6 1 University of Pittsburgh, Pittsburgh, PA, US; 2 Northwestern University, Feinberg School of Medicine, Chicago, IL, US; 3 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 4 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, US; 5 Rush University Medical Center, Chicago, IL, US; 6 Johns Hopkins University School of Medicine, Baltimore, MD, US THURSDAY, FEBRUARY 26, 2015 Session P-G4 Poster Session

464 Bridging Genetics, Histopathology, and Neurocognition in the Context of HAND Andrew Levine 1 ;Virawudh Soontornniyomkij 2 ; Cristian L. Achim 2 ; Ben Gouaux 2 ; Eliezer Masliah 2 ; Janet Sinsheimer 3 ; Elyse Singer 1 ; David J. Moore 2 1 University of California Los Angeles, Long Beach, CA, US; 2 University of California San Diego, San Diego, CA, US; 3 University of California Los Angeles, Los Angeles, CA, US

TUESDAY, FEBRUARY 24, 2015 Session P-G5 Poster Session

Poster Hall

2:30 pm– 4:00 pm HAND Diagnosis and Predictors 465 Relative Risk and Factors AssociatedWith Progression to Symptomatic HAND Sean B. Rourke 1 ; John Gill 2 ; Anita Rachlis 1 ; Colin Kovacs 3 ; Gordon Arbess 5 ; Jason Brunetta 3 ; Adriana Carvalhal 5 ; Chris Power 2 ; Ann N. Burchell 4 ;Tsegaye Bekele 4 1 University of Toronto, Toronto, Canada; 2 University of Alberta, Calgary, Canada; 3 Maple Leaf Medical Clinic, Toronto, Canada; 4 The Ontario HIV Treatment Network, Toronto, Canada; 5 St. Michael’s Hospital, Toronto, Canada 466 Monocytes Activation Characterizes Immune Failure but Not Cognitive Impairment on ART Antonio Muscatello 1 ; Davide Mangioni 1 ; Paolo Perseghin 2 ; Arianna Incontri 2 ; Alessandro Soria 1 ; Nicola Squillace 1 ; Giuseppe Lapadula 1 ; Sebastiano Leone 1 ; Andrea Gori 1 ; Alessandra Bandera 1 1 S. Gerardo Hospital, Monza, Italy; 2 San Gerardo Hospital–UOS Aferesi e Nuove Tecnologie Trasfusionali–SIMT, Monza, Italy 467 The VACS Index Predicts Change in Neurocognitive Functions in People With HIV Sean B. Rourke 1 ; John Gill 2 ; Anita Rachlis 1 ; Amy Justice 7 ; Colin Kovacs 3 ; Gordon Arbess 4 ; Jason Brunetta 3 ; Adriana Carvalhal 4 ; Chris Power 6 ; Ann N. Burchell 5 1 University of Toronto, Toronto, Canada; 2 University of Alberta, Calgary, Canada; 3 Maple Leaf Medical Clinic, Toronto, Canada; 4 St. Michael’s Hospital, Toronto, Canada; 5 The Ontario HIV Treatment Network, Toronto, Canada; 6 University of Alberta, Edmonton, Canada; 7 Yale University School of Medicine, New Haven, CT, US 468 When Diagnosing HAND, Should Visuospatial Functioning be Evaluated? Talia Shirazi 1 ; Angela Summers 1 ; Sally Steinbach 2 ; Suad Kapetanovick 1 ; Avindra Nath 2 ; Bryan Smith 2 ; Joseph Snow 1 1 National Institute of Mental Health (NIMH), Bethesda, MD, US; 2 National Institute of Neurological Disorders and Stroke, Bethesda, MD, US 469 Predictors of Neurocognitive Decline Among Aviremic Individuals in the CHARTER Cohort Marie-Josée Brouillette 1 ;TracyYuen 2 ; Susan C. Scott 2 ; Lesley K. Fellows 3 ; Robert Heaton 4 ; Scott Letendre 4 ; Ronald J. Ellis 4 ; Nancy Mayo 2 the CHARTER group 1 McGill University Health Centre, Montreal, Canada; 2 McGill University Health Centre, Montreal, Canada; 3 Montreal Neurological Hospital, Montreal, Canada; 4 University of California San Diego, San Diego, CA, US 470 Association Between Plasma Homocysteine Levels and Neuronal Injury in Untreated HIV Erika Ahlgren 1 ; Lars Hagberg 1 ; Lars-Magnus Andersson 1 ; Staffan Nilsson 2 ; Dietmar Fuchs 3 ; Henrik Zetterberg 1 ; Magnus Gisslén 1 1 University of Gothenburg, Gothenburg, Sweden; 2 Chalmers University of Technology, Gothenburg, Sweden; 3 Innsbruck Medical University, Innsbruck, Austria 471 Plasma MicroRNA Profiling Predicts HIV-Associated Neurocognitive Disorder Eugene L. Asahchop 1 ;William G. Branton 1 ; Segun M. Akinwumi 2 ; Noshin Koenig 3 ; Esther Fujiwara 2 ; John Gill 3 ; Christopher Power 1 1 University of Alberta, Edmoton, Canada; 2 University of Alberta, Edmonton, Canada; 3 Southern Alberta Clinic, Calgary, Canada

Poster Hall

Poster Listings

40

CROI 2015