CROI 2015 Program and Abstracts

Poster Listings

THURSDAY, FEBRUARY 26, 2015 Session P-G8 Poster Session

489 The Impact of Physical Activity on Cognition in MenWith andWithout HIV Anne Monroe 1 ; Long Zhang 7 ; Lisa P. Jacobson 7 ;ToddT. Brown 1 ; Michael Plankey 4 ; Eric Miller 3 ; JamesT. Becker 5 ; Eileen Martin 6 ; Ned Sacktor 1 On behalf of the Multicenter AIDS Cohort Study 1 Johns Hopkins University School of Medicine, Baltimore, MD, US; 2 Johns Hopkins University School of Medicine, Baltimore, MD, US; 3 University of California Los Angeles, Los Angeles, CA, US; 4 Georgetown University, Washington, DC, US; 5 University of Pittsburgh, Pittsburgh, PA, US; 6 Rush University Medical Center, Chicago, IL, US; 7 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US 490 Abnormal Lung Function AssociatedWith Abnormal Brain Structure and Function in HIV Alison Morris 1 ; Lawrence Kingsley 1 ; Matthew Gingo 1 ; Meghan Fitzpatrick 1 ; Roger Detels 3 ; Oto Martinez 3 ; Eric Miller 3 ; Jeffrey Alger 3 ; Eric Kleerup 3 ; JamesT. Becker 1 1 University of Pittsburgh, Pittsburgh, PA, US; 2 University of Pittsburgh, Pittsburgh, PA, US; 3 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, US 491 HIV DNA and Neurocognitive Impairment in Older Subjects on Suppressive ART Michelli Faria de Oliveira 1 ; Ben Murrell 1 ; Josué Pérez-Santiago 1 ; MilenkaVargas 1 ; Ronald J. Ellis 2 ; Scott Letendre 2 ; Igor Grant 2 ; Davey M. Smith 1 ; Steven P.Woods 2 ; Sara Gianella 1 1 University of California San Diego, La Jolla, CA, US; 2 HIV Neurobehavioral Research Center, San Diego, CA, US 492 Suppressive ART Is Key to Reduce Neurocognitive Impairment in Aging HIV+ Individuals Christina C. Yek 1 ; David M. Smith 1 ; GabrielWagner 1 ; Susan Morgello 2 ; Scott Letendre 1 ; Igor Grant 1 ; Sergei L. Kosakovsky Pond 1 ; Sara Gianella 1 On behalf of the CHARTER group 1 University of California San Diego, San Diego, CA, US; 2 Icahn School of Medicine at Mount Sinai, New York, NY, US 493 Mixed Membership Trajectory Model of Cognitive Impairment in the MACS Samantha A. Molsberry 1 ; Fabrizio Lecci 2 ; Brian Junker 2 ; Sandra Reynolds 3 ; Andrew Levine 4 ; Eileen Martin 5 ; Cynthia A. Munro 6 ; Ned Sacktor 6 ; JamesT. Becker 1 ; Neuropyschology Working Group O. Multicenter AIDS Cohort Study 7 1 University of Pittsburgh, Boston, MA, US; 2 Carnegie Mellon University, Pittsburgh, PA, US; 3 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 4 University of California Los Angeles, Los Angeles, CA, US; 5 Rush University Medical Center, Chicago, IL, US; 6 Johns Hopkins University School of Medicine, Baltimore, MD, US; 7 National Institutes of Health (NIH), Bethesda, MD, US 494 Brain Structural Correlates of Trajectories to Cognitive Impairment in HIV Disease James T. Becker 1 ; Mikhail Popov 1 ; Samantha A. Molsberry 1 ; Fabrizio Lecci 2 ; Brian Junker 2 ; Sandra Reynolds 3 ; Eric Miller 4 ; Cynthia A. Munro 5 ; Ann Ragin 6 ; Ned Sacktor 5 1 University of Pittsburgh, Pittsburgh, PA, US; 2 Carnegie Mellon University, Pittsburgh, PA, US; 3 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 4 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, US; 5 Johns Hopkins University School of Medicine, Baltimore, MD, US; 6 Northwestern University, Feinberg School of Medicine, Chicago, IL, US 495 Cognitive Reserve and Neuropsychological Functioning in Older HIV- Infected People Benedetta Milanini 1 ; Nicoletta Ciccarelli 1 ; Silio Limiti 1 ; Pierfrancesco Grima 2 ; Massimiliano Fabbiani 1 ; Barbara Rossetti 3 ; ElenaVisconti 1 ; EnricaTamburrini 1 ; Roberto Cauda 1 ; Simona Di Giambenedetto 1 1 Institute of Infectious Diseases, Catholic University of Sacred Hearth, Rome, Italy; 2 Division of Infectious Diseases, “S. Caterina Novella” Hospital, Galatina, Italy; 3 Division of Infectious Diseases, University of Siena, Italy

Poster Hall

2:30 pm– 4:00 pm Mitochondrial Dysfunction in HAND and Depression 496 Mitochondrial DNA, Neurologic and Systemic Inflammation, and Immune Dysregulation Josué Pérez-Santiago ; Michelli Faria de Oliveira; Susanna R.Var; Steven P.Woods; Sara GianellaWeibel; Sanjay Mehta; Ben Murrell;Tyler R. Day; Ronald J. Ellis University of California San Diego, La Jolla, CA, US 497 CSF Metabolomics Implicate Bioenergetic Adaptation as a Neural Mechanism Regulating Shifts in the Cognitive States of HIV-Infected Subjects Norman J. Haughey 1 ; Alex DIckens 1 ; Reena Deutsch 2 ; Michelle Mielke 3 ;Timothy Claridge 4 ; Igor Grant 2 ;Thomas Marcotte 2 ; Scott Letendre 2 ; Justin McArthur 1 1 Johns Hopkins University School of Medicine, Baltimore, MD, US; 2 University of California San Diego, San Diego, CA, US; 3 Mayo Clinic, Rochester, MN, US; 4 University of Oxford, Oxford, United Kingdom 498 Altered Monoamine and Acylcarnitine Metabolites in HIV Patients with Depression Edana Cassol 1 ;Vikas Misra 2 ; Susan Morgello 3 ; Gregory D. Kirk 4 ; Shruti H. Mehta 4 ; Dana H. Gabuzda 2 1 Carleton University, Ottawa, Canada; 2 Dana-Farber Cancer Institute, Boston, MA, US; 3 Mount Sinai Hospital, New York, NY, US; 4 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US 499 Mitochondrial Injury and Cognitive Function in HIV Infection and Methamphetamine Susanna R. Var ;Tyler R. Day; AndrejVitomirov; Davey M. Smith;Virawudh Soontornniyomkij; Cristian L. Achim; Sanjay Mehta; Josué Pérez-Santiago University of California San Diego, San Diego, CA, US 500 Efavirenz-Induced Nitric Oxide Affects Mitochondrial Function in Glial Cells Haryes A. Funes 1 ; Fernando Alegre 2 ; Miriam Polo 2 ; Ana Blas-García 2 ; Juan V. Espluges 3 ; Nadezda Apostolova 4 1 Universidad de Valencia, Valencia, Spain; 2 Universidad de Valencia/FISABIO, Valencia, Spain; 3 Universidad de Valencia/FISABIO/CIBERehd, Valencia, Spain; 4 Universidad Jaume I, Castellón, Spain 2:30 pm– 4:00 pm Neuropathogenesis Mechanisms 501 Role of HIV Strain, Accessory Proteins, and Cytokines in Macrophage HO-1 Deficiency Alexander J. Gill ; Patricia J.Vance; Ronald G. Collman; Dennis L. Kolson University of Pennsylvania, Philadelphia, PA, US 502 Atorvastatin Reverses the HIV-induced HO-1 Defect in Primary Human Macrophages Melanie R. Duncan ; Alexander J. Gill; AnjanaYadav; Dennis L. Kolson; Ronald G. Collman University of Pennsylvania, Philadelphia, PA, US 503 Enhanced Antagonism of BST-2 by Neurovirulent SIV Envelope Kenta Matsuda ; Chia-Yen Chen; FanWu; Ronald Plishka; Alicia Buckler-White; Klaus Strebel;Vanessa M. Hirsch National Institutes of Health (NIH), Bethesda, MD, US 504 MEMRI Reflects HIV-1-Associated Human Pathobiology in a Rodent NeuroAIDS Model Aditya N. Bade ; Santhi Gorantla; Prasanta K. Dash; Edward Makarov; Balasrinivasa R. Sajja; Larisa Poluektova; Howard Gendelman; Michael Boska;Yutong Liu University of Nebraska Medical Center, Omaha, NE, US Session P-G9 Poster Session Poster Hall

Poster Listings

42

CROI 2015