CROI 2015 Program and Abstracts

Poster Listings

WEDNESDAY, FEBRUARY 25, 2015 Session P-C10 Poster Session

304 Genital CMV Shedding Predicts Syphilis Acquisition in HIV-Infected MSM on ART Sara GianellaWeibel 1 ; David M. Smith 1 ; Eric Daar 2 ; Michael Dube 3 ; Andrea Lisco 4 ; ChristopheVanpouille 5 ; Richard Haubrich 1 ; Sheldon Morris 1 1 University of California San Diego, La Jolla, CA, US; 2 Los Angeles Biomedical Research Institute at Harbor–UCLA Medical Center, Torrance, CA, US; 3 University of Southern California Keck School of Medicine, Los Angeles, CA, US; 4 National Institute of Allergy and Infectious Diseases, Bethesda, MD, US; 5 National Institute of Child Health and Human Development, Bethesda, MD, US 2:30 pm– 4:00 pm Aging and Immune Senescence 305 Early Start of ART Affects Late Markers of Immune Senescence Sharon L. Karmon ;Teresa H. Evering; Melissa La Mar; Martin Markowitz Aaron Diamond AIDS Research Center, an Affiliate of the Rockefeller University, New York, NY, US 306 Chronic HIV Infection Exacerbates Cellular Aging Markers in Isolated T-Cell Subsets Anthony Hsieh ; Beheroze Sattha; Hélène Côté CIHRTeam in Cellular Aging and HIV Comorbidities inWomen and Children (CARMA cohort) University of British Columbia, Vancouver, Canada 307 Age Associated Increases in Markers of Microbial Translocation and Inflammation in HIV-1 Infection Eileen Scully 1 ; Ainsley Lockhart 1 ; Lisa Huang 2 ; Marisol Romero-Tejeda 1 ; Mary Albrecht 4 ; Chrstine D. Palmer 1 ; Ronald Bosch 3 ; Marcus Altfeld 1 ; Daniel Kuritzkes 2 ; Nina Lin 5 1 Ragon Institute of MGH, MIT and Harvard, Jamaica Plain, MA, US; 2 Brigham and Women’s Hospital, Boston, MA, Boston, MA, US; 3 Harvard School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA, US; 4 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US; 5 Boston University School of Medicine, Boston, MA, US 2:30 pm– 4:00 pm Immune Pathogenesis of IRIS 308 Vitamin D, D-Dimer, IFNy and sCD14 Predict IRIS in a Prospective Multicenter Study LauraW. Musselwhite 1 ; AnnTierney 2 ; Susan Ellenberg 2 ; Pablo F. Belaunzarán-Zamudio 5 ; Adam Rupert 3 ; Ian Sanne 4 ; Michael M Lederman 6 ; Juan Sierra-Madero 5 ; Irini Sereti 7 1 Duke University, Durham, NC, US; 2 University of Pennsylvania, Philadelphia, PA, US; 3 Leidos Biomedical Inc., Reston, VA, US; 4 University of the Witwatersrand, Johannesburg, South Africa; 5 Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico; 6 Case Western Reserve University, Cleveland, OH, US; 7 National Institutes of Health (NIH), Bethesda, MD, US 309 LC-MS Analysis of Metabolites Differentiating IRIS FromNon-IRIS in ACTG Study A5221 Mary A. De Groote 1 ; Laura Ashton 1 ; Marisa Harton 1 ; Sam Bokatzien 2 ; KristoforWebb 1 ; Carlos Adriano Matos de Silva 1 ; Reem Al-Mubarak 1 ; Sebabratra Mahapatra 1 ; Diane Havlir 3 ; John Belisle 1 1 Colorado State University, Fort Collins, CO, US; 2 National Jewish Health, Denver, CO, US; 3 University of California San Francisco, San Francisco, CA, US 310 Associations Between Plasma Cytokine and Microbial Translocation Biomarkers and IRIS Margaret A. Fischl 2 ; Linda J. Harrison 1 ;Varghese George 2 ; Margaret Roach 2 ; Xiao-Dong Li 3 ; David Asmuth 3 ; PabloTebas 4 ; CamlinTierney 1 ; Catherine Godfrey 5 ; Savita Pahwa 2 1 Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA, US; 2 University of Miami Miller School of Medicine, Miami, FL, US; 3 University of California Davis, Sacramento, CA, US; 4 University of Pennsylvania, Philadelphia, PA, US; 5 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US Session P-C8 Poster Session Poster Hall Session P-C9 Poster Session Poster Hall

Poster Hall

2:30 pm– 4:00 pm Immune Activation and HIV Pathogenesis 312 Inflammatory Biomarkers Decline but Do Not Normalize After 10 Years of cART Kenneth A. Lichtenstein 1 ; Carl Armon 2 ;Vijaya Knight 1 ; Rafeul Alam 1 1 National Jewish Health, Denver, CO, US; 2 Children’s Hospital Colorado, Aurora, CO, US 313 Persistently High IL-18 and sCD14 Are Independently AssociatedWith Clinical Failure Ashwin Balagopal 1 ; Nikhil Gupte 1 ; James Hakim 2 ; Mina C. Hosseinipour 3 ; Nagalingeswaran Kumarasamy 4 ; Andrea Cox 1 ; Ian Sanne 7 ; David Asmuth 5 ;Thomas Campbell 6 ; Amita Gupta 1 On behalf of the ACTG 1 Johns Hopkins University School of Medicine, Baltimore, MD, US; 2 University of Zimbabwe, College of Health Sciences, Harare, Zimbabwe; 3 University of North Carolina, Chapel Hill, NC, US; 4 Y.R.G. Care, Chennai, India; 5 University of California San Diego, San Diego, CA, US; 6 University of Colorado, Denver, CO, US; 7 ACTG, Washington, DC, US 314 Impact of Partner HIV Status on Immune Activation and Inflammation During Chronic HIV Shameem Z. Jaumdally 1 ; Pamela Gumbi 1 ; Hoyam Gamieldien 1 ; Anabela Picton 2 ; Caroline Tiemessen 2 ; Lindi Masson 1 ; Lenine Liebenberg 3 ; David Coetzee 1 ; Anna-LiseWilliamson 1 ; Jo-Ann Passmore 1 1 University of Cape Town, Cape Town, South Africa; 2 National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; 3 Centre for AIDS Programme Research in South Africa, Durban, South Africa; 4 University of Cape Town, Cape Town, South Africa 315 Pretherapy Inflammation and Long-Term CD4 Response to Antiretroviral Therapy Amit C. Achhra 1 ; Andrew N. Phillips 2 ; Sean Emery 1 ; Rodger D. MacArthur 3 ; Hansjakob Furrer 4 ; Stéphane DeWit 5 ; Marcelo H. Losso 6 ; Matthew G. Law 1 On behalf of the INSIGHT SMART and FIRST Study groups 1 Kirby Institute, University of New South Wales, Sydney, Australia; 2 University College London, London, United Kingdom; 3 Wayne State University, Detroit, MI, US; 4 University Hospital Bern, Bern, Switzerland; 5 Saint-Pierre University Hospital, Brussels, Belgium; 6 Hospital J.M. Ramos Mejía, Buenos Aires, Argentina 316 Plasma Levels of sCD163 Predict All-Cause Mortality FromHIV Infection Troels Bygum Knudsen 1 ; Janne Petersen 2 ; Holger Jon Møller 3 ; Søren Moestrup 4 ; Jesper Eugen-Olsen 2 ; Gitte Kronborg 1 ;Thomas Benfield 1 1 Copenhagen University Hospitals, Hvidovre, Copenhagen, Denmark; 2 Copenhagen University Hospitals, Hvidovre, Copenhagen, Denmark; 3 Aarhus University Hospital, Aarhus, Denmark; 4 Aarhus University, Aarhus, Denmark 317 Immunologic Pathways That Predict Mortality in HIV+ Ugandans Initiating ART Sulggi A. Lee 1 ; Helen Byakwaga 2 ;Yap Boum 2 ;Tricia Burdo 3 ;Yong Huang 1 ; Jessica Haberer 5 ; Annet Kembabazi 2 ; David R. Bangsberg 5 ; Jeffrey Martin 1 ; PeterW. Hunt 1 1 University of California San Francisco, San Francisco, CA, US; 2 Mbarara University of Science and Technology, Mbarara, Uganda; 3 Boston College, Boston, MA, US; 4 University of California San Francisco, San Francisco, CA, US; 5 Massachusetts General Hospital and Harvard University, Boston, MA, US 318 Immune Activation Impairs Yellow Fever Vaccine Efficacy in HIV-Infected Patients Vivian I. Avelino-Silva 1 ; KarinaT. Miyaji 1 ; Marisol Simoes 2 ; Marcos Freire 2 ; Ana Sartori 1 ; PeterW. Hunt 3 ; Karine Milani 1 ; Augusto Mathias 1 ; Ana Paula Batista 1 ; Esper G. Kallas 1 1 University of Sao Paulo Medical School, Sao Paulo, Brazil; 2 Fundaçao Oswaldo Cruz, Rio de Janeiro, Brazil; 3 University of California San Francisco, San Francisco, CA, US; 4 University of Sao Paulo Medical School, Sao Paulo, Brazil 319 Association Between sCD163 and CMV IgG in Virologically Suppressed HIV+ Patients Aimee Hodowanec 1 ; BrettWilliams 1 ; Barbara Hanson 1 ; Britt Livak 2 ; Sheila Keating 3 ; Nell Lurain 1 ; Oluwatoyin M. Adeyemi 4 1 Rush University Medical Center, Chicago, IL, US; 2 University of Chicago, Chicago, IL, US; 3 Blood Systems Research Institute/University of California San Francisco, San Francisco, CA, US; 4 Ruth M Rothstein CORE Center, Chicago, IL, US

Poster Listings

311 Potential Role of IL-1 and IL-10 Pathways in IRIS Pathogenesis

Ainhoa Perez-Diez; Elizabeth Richards ; Stig Jensen; Eleanor M.Wilson;Virginia Sheikh; Maura M. Manion; Bruno Andrade;Timothy Myers; Irini Sereti National Institute of Allergy and Infectious Diseases (NIAID), Rockville, MD, US

31

CROI 2015