CROI 2015 Program and Abstracts

Poster Listings

TUESDAY, FEBRUARY 24, 2015 Session P-C5 Poster Session

295 Host Genetic Predictors of Plasma Kynurenine/Tryptophan Among Treated HIV+ Ugandans Sulggi A. Lee 1 ; Joel Mefford 1 ;Yong Huang 1 ; John S.Witte 1 ; Jeffrey Martin 1 ; David R. Bangsberg 2 ;Taisei Mushiroda 3 ; Michiaki Kubo 3 ; Deanna Kroetz 1 ; PeterW. Hunt 1 1 University of California San Francisco, San Francisco, CA, US; 2 Massachusetts General Hospital and Harvard University, Boston, MA, US; 3 RIKEN Center for Genomic Medicine, Wako, Japan 296 Regulation of IL-32 Expression by a Promoter Polymorphism and MicroRNA29b in HIV-1 Patients Carolina Scagnolari ; Giulia Cacciotti; Carla Selvaggi; Noemi Giustini; Ivano Mezzaroma; Massimo Gentile; Gabriella D’Ettorre; OmbrettaTurrziani;VincenzoVullo; Guido Antonelli Sapienza University of Rome, Rome, Italy Gerrit Ahrenstorf 1 ; Hui Zhi Low 1 ; Katja kniesch 1 ; Matthias Stoll 1 ; Dirk Meyer-Olson 1 ;Torsten Matthias 2 ; Reinhold E. Schmidt 1 ;TorstenWitte 1 1 Hannover Medical School, Hannover, Germany; 2 AESKU Diagnostics, Wendelsheim, Germany 298LB SIV Infection Triggers Endothelial Dysfunction and Diminished Expression of Krüppel-Like Factor 2 (KLF2) in Nonhuman Primates Soumya Panigrahi 1 ; Michael L. Freeman 1 ; joseph C. mudd 4 ; Nicholas Funderburg 2 ; Scott Sieg 1 ; David A. Zidar 1 ; Mirko Paiardini 3 ; FrancoisVillinger 3 ; Mukesh K. Jain 1 ; michael lederman 1 1 Case Western Reserve University/University Hospitals Medical Center, Cleveland, OH, US; 2 Ohio State University School of Health and Rehabilitation Sciences, Columbus, OH, US; 3 Emory University, Atlanta, GA, US; 4 Lab of Molecular Microbiology, Bethesda, MD, US Individuals Leslie R. Cockerham 1 ; Claire Emson 2 ; Ma Somsouk 1 ; Kara Harvill 1 ; Kevin Li 2 ; Scott M. Turner 2 ; Martin L. Decaris 2 ; Marc K. Hellerstein 3 ; Steven G. Deeks 1 ; Hiroyu Hatano 1 1 University of California San Francisco, San Francisco, CA, US; 2 KineMed, Inc, Emeryville, CA, US; 3 University of California Berkeley, Berkeley, CA, US 299LB A Novel Method Using 2 H 2 O to Measure Collagen Turnover in HIV-Infected 2:30 pm– 4:00 pm HIV/CMV Interactions in Transmission and Pathogenesis 300 Effect of CMV and HIV Replication on T-Cell Exhaustion and Senescence During ART Jennifer M. Dan 1 ; Marta Massanella 1 ; David M. Smith 1 ; Eric S. Daar 2 ; Michael P. Dube 3 ; Richard Haubrich 1 ; Sheldon Morris 1 ; Sara GianellaWeibel 1 1 University of California San Diego, La Jolla, CA, US; 2 Harbor–University of California Los Angeles Medical Center, Torrance, CA, US; 3 University of Southern California Keck School of Medicine, Los Angeles, CA, US 301 HIV Myeloid Derived Suppressor Cells Control Cytomegalovirus Inflammation by IL-27 Ankita Garg ; Stephen Spector University of California San Diego, La Jolla, CA, US 302 Persistent Elevation of Inflammation Markers in HIV+ Persons With CMV Disease Melissa Schechter 1 ; Bruno Andrade 2 ; Eleanor M.Wilson 1 ;Virginia Sheikh 2 ; Sonya Krishnan 2 ; Margaret Caplan 1 ; Gregg Roby 2 ; Adam Rupert 3 ; Peter Burbelo 4 ; Irini Sereti 2 1 NIAID, Leidos Biomedical Inc., Fredrick, MD, US; 2 National Institute of Allergy and Infectious Diseases, Bethesda, MD, US; 3 NIAID, Leidos Biomedical Inc., Fredrick, MD, US; 4 National Institute of Dental and Craniofacial Research, Bethesda, MD, US 303 sCD163 Increase in HIV/CMV-Coinfected Subjects Included in ICONA Cohort Serena Vita 3 ; Miriam Lichtner 1 ; Giulia Marchetti 2 ; Claudia Mascia 3 ; Esther Merlini 2 ; Paola Cicconi 2 ;VincenzoVullo 3 ; Pier LuigiViale 5 ; Alberto Costantini 4 ; Antonella d’Arminio Monforte 2 For the Icona Foundation Study 1 University of Rome La Sapienza, Polo Pontino, Latina, Italy; 2 San Paolo Hospital, Milano, Italy; 3 University of Rome La Sapienza, Rome, Italy; 4 University of Ancona, Ancona, Italy; 5 University of Bologna, Bologna, Italy 297 LILRA3 Deletion Is a Genetic Risk Factor of HIV Infection THURSDAY, FEBRUARY 26, 2015 Session P-C7 Poster Session Poster Hall

Poster Hall

2:30 pm– 4:00 pm Studies of HIV-Exposed Uninfected Individuals 287 HIV-Exposed Seronegative MSM Have Increased Novel Antiviral Factors in Rectal Mucosa Laura Romas 1 ; Klara Hasselrot 2 ; Kristina Broliden 2 ; Carolina Herrera 3 ; GarrettWestmacott 4 ; Francis Plummer 4 ;Terry B. Ball 4 ; Adam Burgener 1 1 University of Manitoba, Winnipeg, Canada; 2 Karolinska Institutet, Stockholm, Sweden; 3 Imperial College London, London, United Kingdom; 4 Public Health Agency of Canada, Winnipeg, Canada 288 PBMC FromHighly Exposed Seronegative Individuals Inhibit Transmitted Founder HIV Kevin C. Olivieri 1 ; Eunyoung Kim 3 ; Susan Little 5 ; MichaelTurchin 4 ;Vanessa Serrano 1 ; Amna Rasheed 2 ; Quy Nguyen 1 ; Paul Dejesus 1 ; StevenWolinsky 3 ; Sumit Chanda 1 1 Sanford-BurnhamMedical Research Institute, San Diego, CA, US; 2 University of California Los Angeles (UCLA), Los Angeles, CA, US; 3 Northwestern University, Feinberg School of Medicine, Chicago, IL, US; 4 University of Chicago, Chicago, IL, US; 5 University of California San Diego (UCSD), San Diego, CA, US 289 HIV-1-Exposed Seronegative Persons Have Lower Mucosal Innate Immune Reactivity Jennifer A. Fulcher 1 ; Jennifer C. Hoffman 1 ; Laura M. Romas 2 ; KarenTanner 1 ;Terry Saunders 1 ; Julie Elliott 1 ; Adam D. Burgener 2 ; Peter A. Anton 1 ; Otto O.Yang 1 1 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, US; 2 University of Manitoba, Winnipeg, Canada 290 Increased Levels of Regulatory T-cells CorrelateWith Protection From HIV Infection 2:30 pm– 4:00 pm Host Factors in HIV Pathogenesis 291 Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control István Bartha 1 ; Paul J. McLaren 1 ; Chanson J. Brumme 2 ; Richard Harrigan 2 ; AmalioTelenti 3 ; Jacques Fellay 1 1 École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; 2 BC Centre for Excellence in HIV/AIDS, Vancouver, Canada; 3 J. Craig Venter Institute, La Jolla, CA, US 292 Host Gene Expression Profiles and HIV-1 Infection Outcomes Romel D. Mackelprang 1 ; Ali Filali 2 ; Mark Cameron 2 ; Rafick P. Sekaly 2 ; Elly Katabira 3 ; Allan Ronald 4 ; Glenda Gray 5 ; Connie Celum 1 ; M Juliana McElrath 5 ; Jairam R. Lingappa 1 1 University of Washington, Seattle, WA, US; 2 Case Western Reserve University, Cleveland, OH, US; 3 Makerere University College of Health Sciences, Kampala, Uganda; 4 University of Manitoba, Winnipeg, Canada; 5 Fred Hutchinson Cancer Research Center, Seattle, WA, US 293 Refinement of Association Signals Assessment of Residual Heritability in Host Control of HIV Viral Load Paul J. McLaren; Istvan Bartha ; Jacques Fellay École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 294 Genetic and Clinical Predictors of CD4 Recovery During Suppressive cART: WIHS Ruth M. Greenblatt 1 ; Kord Kober 1 ; Peter Bacchetti 1 ; Ross Boylan 1 ; Kathryn Anastos 2 ; Mardge Cohen 5 ; Mary A.Young 3 ; Deborah Gustafson 4 ; Bradley Aouizerat 1 On behalf of theWIHS 1 University of California San Francisco, San Francisco, CA, US; 2 Montefiore Medical Center, University Hospital for Albert Einstein College of Medicine, New York, NY, US; 3 Georgetown University, Washington, DC, US; 4 State University of New York, Downstate, Brooklyn, NY, US; 5 CORE Center, Chicago, IL, US; 6 National Institutes of Health (NIH), Bethesda, MD, US Laura Pattacini 1 ; Jared Baeten 2 ; KatherineThomas 2 ; Tayler Fluharty 1 ; Pamela Murnane 2 ; Deborah Donnell 2 ; Nelly Mugo 2 ; Jairam R. Lingappa 2 ; Connie Celum 2 ; Jennifer Lund 1 1 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, US; 2 University of Washington, Seattle, WA, US Session P-C6 Poster Session Poster Hall

Poster Listings

30

CROI 2015