CROI 2015 Program and Abstracts

Poster Listings

268 Monocyte/Macrophage Activation and Recruitment to Mucosal Sites in SIV Pathogenesis Jan Kristoff 1 ; Jenny Stock 1 ;Tianyu He 1 ; Bruno Andrade 2 ; Benjamin Policicchio 1 ; Alan Landay 3 ; Ivo Francischetti 2 ; Cristian Apetrei 1 ; Irini Sereti 2 ; Ivona Pandrea 1 1 University of Pittsburgh, Pittsburgh, PA, US; 2 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US; 3 Rush University, Chicago, IL, US 269 Rectal Tenofovir Gel Usage Is AssociatedWith Changes in the Mucosal Proteome Adam Burgener 1 ; Laura Romas 1 ; Kenzie Birse 1 ; Kenneth H. Mayer 3 ; Irma Febo 5 ; Ross Cranston 2 ; Alex Carbarballo-Dieguez 4 ; Ian McGowan 2 1 University of Manitoba, Winipeg, Canada; 2 University of Pittsburgh, Pittsburgh, PA, US; 3 Harvard Medical School, Boston, MA, US; 4 Columbia University, New York, NY, US; 5 University of Puerto Rico, San Juan, US 270 Links Between Systemic and Mucosal Immunity in Treated HIV Infection Talía Sainz 1 ; Sergio Serrano-Villar 2 ; Gregory Melcher 3 ; Zhong-Min Ma 3 ; Christopher Miller 3 ; Netanya S. Utay 4 ; Basile Siewe 5 ; PaoloTroia-Cancio 3 ; Elizabeth Sinclair 6 ; David Asmuth 3 1 Hospital Universitario Gregorio Marañón, Madrid, Spain; 2 Hospital Ramon y Cajal, Madrid, Spain; 3 University of California Davis, Davis, CA, US; 4 University of Texas Medical Branch, Galveston, TX, US; 5 Rush University Medical Center, Chicago, IL, US; 6 University of California San Francisco (UCSF), San Francisco, CA, US 271 No Impact of Early Intensified Antiretroviral Therapy on Gut Immune Reconstitution Connie J. Kim 1 ; Rodney Rousseau 2 ; Colin Kovacs 3 ; Sanja Huibner 2 ; Gabor Kandel 4 ; Erika Benko 3 ; Kamnoosh Shahabi 2 ;TaeWook Chun 5 ; Mario Ostrowski 2 ; Rupert Kaul 2 1 Toronto General Hospital, Toronto, Canada; 2 University of Toronto, Toronto, Canada; 3 Maple Leaf Medical Clinic, Toronto, Canada; 4 St. Michael’s Hospital, Toronto, Canada; 5 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US 272 Altered Properties of Mucosal NK Cell Subsets During Acute HIV-1 Infection Alexandra Schuetz 1 ;Yuwadee Phuang-Ngern 1 ; Eugene Kroon 1 ; Rungsun Rerknimitr 3 ; Nitiya Chomchey 2 ; Nittaya Phanuphak 2 ; Merlin L. Robb 4 ; Jerome H. Kim 4 ; Mark de Souza 2 ; Jintanat Ananworanich 4 RV254/SEARCH 010 and RV304/SEARCH 013 Study Groups 1 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; 2 Thai Red Cross AIDS Research Center, Bangkok, Thailand; 3 Chulalongkorn University, Bangkok, Thailand; 4 US Military HIV Research Program, Silver Spring, MD, US 273 Loss of Cervical Gamma Delta 1 T cells in HIV-InfectedWomen Natasa Strbo 1 ; Maria L. Alcaide 1 ; Laura Romero 1 ; Hector Bolivar 1 ; Deborah L. Jones 1 ; Eckhard R. Podack 1 ; Margaret A. Fischl 1 1 University of Miami, Miami, FL, US; 2 University of Miami, Miami, FL, US 274 T Regulatory Cells Disrupt the CCL20-CCR6 Axis Driving Th17 Homing to the Gut Claire Loiseau 1 ; Mary Requena 1 ; Michelle Cazabat 1 ; Nicolas Carrere 2 ; Bertrand Suc 2 ; Bruno Marchou 2 ; Jacques Izopet 1 ; Pierre Delobel 1 1 Inserm, Toulouse, France; 2 Centre Hospitalier Universitaire de Toulouse, Toulouse, France

276 HLA-KIR-Associated Sites in Gag and Their Effects on Clinical Outcome in Thailand Masahiko Mori 1 ; NuanjunWichukchinda 2 ; Reiko Miyahara 1 ; Archawin Rojanawiwat 2 ; Panita Pathipvanich 3 ;Toshiyuki Miura 1 ; MichioYasunami 1 ; Koya Ariyoshi 1 ; Pathom Sawanpanyalert 2 1 Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; 2 Ministry of Public Health, Nonthaburi, Thailand; 3 Day Care Centre, Lampang Hospital, Lampang, Thailand 277 In KIR3DL1/S1 Heterozygotes Are KIR3DL1 and KIR3DS1 Co-Dominantly Expressed? Zahra Kiani 1 ; Nicole F. Bernard 1 ; Julie Bruneau 2 1 McGill University, Montreal, Canada; 2 Centre de Recherche du Centre Hospitalier de l’Universite de Montreal, Montreal, Canada 278 Disruption of Innate-Like Unconventional T-Cell Subsets in HIV-Infected Children Alka Khaitan 1 ; Adam Kravietz 1 ; IlmetTiina 1 ; Mussa Mwamzuka 2 ; Fatma Marshed 2 ; Cihan Tastan 1 ; Aabid Ahmed 2 ; Bill Borkowsky 1 ; Derya Unutmaz 1 1 New York University School of Medicine, New York, NY, US; 2 Bomu Hospital, Mombasa, Kenya; 3 New York University School of Medicine, New York, NY, US 279 HIV-1 Alters Innate Immune Response to BCG , Which Differs From SIV Infected Mangabeys Melanie Gasper; David Sherman; Donald Sodora Seattle Biomed, Seattle, WA, US 280 High-Level Replication Allows SHIVs to Overcome the Macaque Interferon Response David F. Boyd ; Amit Sharma; Julie M. Overbaugh Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, US 281 Elevated IFN- γ in HIV Patients Using a Novel Assay for Adaptive and Innate Immunity Michelle K. Yong 1 ; Paul Cameron 1 ;Tim Spelman 2 ; Julian Elliott 1 ; Christopher Fairley 4 ; Jeffrey Boyle 3 ; Misato Miyamasu 3 ; Sharon R. Lewin 1 1 Monash University/Alfred Hospital, Melbourne, Australia; 2 Burnet Institute, Melbourne, Australia; 3 Qiagen, Melbourne, Australia; 4 Melbourne Sexual Health Centre, Melbourne, Australia 282 TLR8 Regulation of LILRA3 Is Abrogated in HIV Infection and Correlates to CD4 Counts and Virus Loads 2:30 pm– 4:00 pm Monocytes, Dendritic Cells, and Neutrophils 283 Siglec-1 on Monocytes FromUntreated HIV-1 – Infected Patients Enhances HIV-1 Transfer Maria Pino ; Susana Benet; Itziar Erkizia; Judith Dalmau; Dan Ouchi; Bonaventura Clotet; Javier Martínez-Picado; Nuria Izquierdo-Useros IrsiCaixa Institute for AIDS Research, Badalona, Spain 284 Soluble CD40 Ligand Contributes to Dendritic Cell Mediated T-Cell Dysfunction Elizabeth A. Miller; Ramya Gopal;VanessaValdes; Jeffrey S. Berger; Nina Bhardwaj; Meagan O’Brien Icahn School of Medicine at Mount Sinai, New York, NY, US 285 The Alarmin HMGB1 Is Crucial for the Acquisition of Antiviral pDC Effector Functions Hela Saïdi 1 ; Marlène Bras 1 ; Pauline Formaglio 1 ; Bruno Charbit 1 ; Marie-Thérèse Melki 2 ; Marie-Lise Gougeon 1 On behalf of the Antiviral Immunity, Biotherapy andVaccine Unit 1 Institut Pasteur, Paris, France; 2 Sebia, Evry, France 286 Dysfunctional Neutrophil Responses to SIV Infection Tiffany Hensley-McBain 1 ; Laura E. Richert-Spuhler 1 ; Jillian Gile 1 ; MelonT. Nega 2 ;Thomas H.Vanderford 2 ; Jacob D. Estes 3 ; Brandon F. Keele 3 ; Nichole R. Klatt 1 1 University of Washington, Seattle, WA, US; 2 Emory University, Atlanta, GA, US; 3 Frederick National Laboratory for Cancer Research, Frederick, MD, US Hui Zhi Low ; Gerrit Ahrenstorf;TorstenWitte Hannover Medical School, Hannover, Germany Session P-C4 Poster Session Poster Hall

Poster Listings

WEDNESDAY, FEBRUARY 25, 2015 Session P-C3 Poster Session

Poster Hall

2:30 pm– 4:00 pm Innate and Unconventional T-Cell Responses 275 Effect of KIR2D-Mediated Immunity on Clinical Outcome Among CRF01_ AE-Infected Thais Masahiko Mori 1 ; NuanjunWichukchinda 2 ; Reiko Miyahara 1 ; Archawin Rojanawiwat 2 ; Panita Pathipvanich 3 ;Toshiyuki Miura 1 ; MichioYasunami 1 ; Koya Ariyoshi 1 ; Pathom Sawanpanyalert 2 1 Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; 2 Ministry of Public Health, Nonthaburi, Thailand; 3 Day Care Centre, Lampang Hospital, Lampang, Thailand

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CROI 2015