CROI 2015 Program and Abstracts

Poster Listings

TUESDAY, FEBRUARY 24, 2015 Session P-C1 Poster Session

252 Sources of HIV-1 Transmission in the Ongoing, Concentrated HIV Epidemic Among Men Having Sex With Men in the Netherlands Between July 1996 and December 2010 Oliver Ratmann 1 ; Ard van Sighem 2 ; Daniela Bezemer 2 ; Alexandra Gavryushkina 3 ; Peter Reiss 2 ; Frank deWolf 1 ; Christophe Fraser 1 1 Imperial College London, London, United Kingdom; 2 Stichting HIV Monitoring Foundation, Amsterdam, Netherlands; 3 University of Auckland, Auckland, New Zealand 253 A Direct Comparison of Two Densely SampledWestern European HIV Epidemics: The UK and Switzerland Manon L. Ragonnet-Cronin 1 ; Mohaned Shilaih 2 ; Huldrych F. Günthard 2 ; Jurg Boni 2 ; Sabine Yerly 3 ;Valerie Delpech 4 ; David Dunn 5 ; Roger Kouyos 2 ; Andrew J. Leigh Brown 1 Swiss HIV Cohort Study/UK HIV Drug Resistance Database 1 University of Edinburgh, Edinburgh, United Kingdom; 2 University Hospital Zurich, Zurich, Switzerland; 3 University Hospital Geneva, Geneva, Switzerland; 4 Public Health England, London, United Kingdom; 5 MRC CTU at UCL, London, United Kingdom 2:30 pm– 4:00 pm Next Generation of Next-Generation Sequencing 254 Present Applications of a High-Throughput, Single Measure HIV Genomic Incidence Assay SungYong Park 1 ;Tanzy Love 2 ; Nolan Goeken 1 ; Robert Bolan 3 ; Alan S Perelson 4 ; Michael Dube 1 ; Ha Youn Lee 1 1 Keck School of Medicine at University of Southern California, Los Angeles, CA, US; 2 University of Rochester School of Medicine and Dentistry, Rochester, CA, US; 3 Los Angeles Gay and Lesbian Center, Los Angeles, CA, US; 4 Los Alamos National Laboratory, Los Alamos, CA, US 255 A Comprehensive Analysis of Primer IDs to Study Heterogenous HIV-1 Populations David Seifert 1 ; ArminTöpfer 1 ; Francesca Di Giallonardo 2 ; Stefan Schmutz 2 ; Huldrych F. Günthard 2 ;Volker Roth 3 ; Niko Beerenwinkel 1 ; Karin J. Metzner 2 1 ETH Zurich, Basel, Switzerland; 2 University Hospital Zurich, Zurich, Switzerland; 3 University of Basel, Basel, Switzerland 256 Near Full Length HIV-1 Sequencing to Understand HIV Phylodynamics in Africa in Real Time Siva Danaviah; Justen Manasa; EduanWilkinson; Sureshnee Pillay; Zandile Sibisi; Sthembiso Msweli; Deenan Pillay; Tulio de Oliveira University of KwaZulu-Natal, Durban, South Africa 257 Pan-HIV Next-Gen Sequencing Strategy for Viral Surveillance Michael G. Berg 1 ; JulieYamaguchi 1 ; Elodie Alessandri-Gradt 2 ; Jean-Christophe Plantier 2 ; Catherine Brennan 1 1 Abbott Laboratories, Abbott Park, IL, US; 2 Virology Unit, National Reference for HIV, Rouen, France 258 PCR-Free Full Genome Characterization of Diverse HIV-1 Strains by Nextgen Sequencing Viswanath Ragupathy 1 ; Feng Gao 2 ; Ana Sanchez 2 ; Marco Schito 3 ;Thomas Denny 2 ; Michael Busch 4 ; Jiangqin Zhao 1 ; Christelle Mbondji 1 ; SaiVikramVemula 1 ; Indira Hewlett 1 1 US Food and Drug Administration, Silver Spring, MD, US; 2 Duke Human Vaccine Institute and Departments of Medicine, Duke University Medical Center, Durham, NC, US; 3 Henry Jackson Foundation, DAIDS, NIAID, Bethesda, MD, US; 4 Blood Systems Research Institute/University of California San Francisco, San Francisco, CA, US 259 Full-Length Env Deep Sequencing in a Donor With Broadly Neutralizing V1/V2 Antibodies Ben Murrell 1 ; Melissa Laird 2 ; Elise Landais 3 ; Caroline Ignacio 1 ; Ellen Paxinos 2 ; Pham Phung 4 ; Sergei L. Kosakovsky Pond 1 ; Douglas D. Richman 1 ; Pascal Poignard 3 ; Davey M. Smith 1 1 University of California San Diego, La Jolla, CA, US; 2 Pacific Biosciences, Menlo Park, CA, US; 3 The International AIDS Vaccine Initiative Neutralizing Antibody Center, La Jolla, CA, US; 4 LabCorp, South San Francisco, CA, US THURSDAY, FEBRUARY 26, 2015 Session P-B5 Poster Session Poster Hall

Poster Hall

2:30 pm– 4:00 pm The Gut Microbiome 260 Functional Profiling of the Gut Microbiome in HIV Infection Yolanda Guillén ; Marc Noguera-Julian; Muntsa Rocafort; Mariona Parera; Maria Casadellà; Isabel Bravo; Josep Coll; Julià Blanco; Bonaventura Clotet; Roger Paredes MetaHIV Study Group IrsiCaixa AIDS Res Inst, Hosp Univ Germans Trias i Pujol, Univ Autònoma de Barcelona, Badalona, Spain 261 Gut Microbiota Correlates with HIV-1 Control and Immune Status Muntsa Rocafort ; Marc Noguera-Julian;Yolanda Guillén; Mariona Parera; Maria Casadellà; Isabel Bravo; Josep Coll; Julià Blanco; Bonaventura Clotet; Roger Paredes MetaHIV-Pheno Study Group IrsiCaixa AIDS Res Inst, Hosp Univ Germans Trias i Pujol, Univ Autònoma de Barcelona, Badalona, Spain 262 Butyrate Reduces Pathobiont-Associated HIV-1 Infection and Activation of Gut T Cell Jon Kibbie ; Stephanie Dillon; Eric Lee; Charles Robertson; Daniel N. Frank; Martin McCarter; Cara C.Wilson University of Colorado Anschutz Medical Campus, Aurora, CO, US 263 Maraviroc Does Not Induce Changes in the Gut Microbiome of HIV- Infected Individuals Andrej Vitomirov ; David M. Smith; Susanna R.Var; Maile Karris; Parris Jordan; Douglas D. Richman; Susan Little; Josué Pérez-Santiago University of California San Diego, La Jolla, CA, US 264 Fecal Microbiota of HIV Controllers Is Similar to That of Non – HIV- Infected Individuals Selma N. Alva Hernández ; Sandra M. Pinto Cardoso; NormaTéllez; Akio Murakami- Ogasawara; Gustavo Reyes-Terán National Institute of Respiratory Diseases, Research Center in Infectious Diseases, Mexico City, Mexico 265 Impact of 2 Antiretroviral Regimens on Fecal Microbial Diversity and Composition Sandra M. Pinto Cardoso ; Selma N. Alva Hernández; NormaTéllez; Akio Murakami- Ogasawara; Gustavo Reyes-Terán National Institute of Respiratory Diseases, Mexico City, Mexico 266 Targeting Gut Dysbiosis With Prebiotics and Glutamine in HIV-Infected Subjects Sergio Serrano-Villar 1 ; JorgeVázquez-Castellanos 2 ; AlejandroVallejo 1 ; Sara Ferrando- Martínez 4 ;Talía Sainz 3 ; MarVera 5 ; Santiago Moreno 1 ; Andrés Moya 2 ; María José Gosalbes 2 ; Vicente Estrada 6 1 University Hospital Ramón y Cajal, Madrid, Spain; 2 FISABIO-Salud Pública, Valencia, Spain; 3 University Hospital La Paz, Madrid, Spain; 4 University Hospital Virgen del Rocío, Sevilla, Spain; 5 Centro Sandoval, Madrid, Spain; 6 University Hospital Clínico San Carlos, Madrid, Spain 2:30 pm– 4:00 pm The Mucosa in HIV/SIV Pathogenesis 267 Impact of Mucosal Immunity and HIV Persistence on CD4/CD8 Ratio After ART Initiation Sergio Serrano-Villar 1 ;Talía Sainz 2 ;TaeWook-Chun 3 ; Netanya S. Utay 5 ; Zhong-Min Ma 4 ; Basile Siewe 6 ; Steven Deeks 7 ; Richard Pollard 4 ; Christopher Miller 4 ; David Asmuth 4 1 University Hospital Ramón y Cajal, Madrid, Spain; 2 University Hospital La Paz, Madrid, Spain; 3 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US; 4 University of California Davis, Davis, CA, US; 5 University of Texas, Galveston, TX, US; 6 Rush University Medical Center, Chicago, IL, US; 7 University of California San Francisco, San Francisco, CA, US Session P-C2 Poster Session Poster Hall

Poster Listings

28

CROI 2015