CROI 2015 Program and Abstracts

Poster Listings

Session P-C11 Poster Session

Poster Hall

Session P-C13 Poster Session

Poster Hall

2:30 pm– 4:00 pm Manipulating Immune Activation 320 The mTORC1 Inhibitors, Temsirolimus and Everolimus, Suppress HIV Patient-Derived CD4+ T-Cell Death and Activation In Vitro Clovis S. Palmer 1 ; Matias Ostrowski 4 ; Jingling Zhou 1 ; Linda Lam 1 ; Alan Landay 2 ; Anthony Jaworowski 1 ; Joseph M. McCune 3 ; Suzanne M. Crowe 1 1 Burnet Institute, Melbourne, Australia; 2 Rush University Medical Center, Chicago, IL, US; 3 University of California San Francisco, San Francisco, CA, US; 4 Instituto de Investigaciones Biomédicas en Retrovirus y SIDA, Buenos Aires, Argentina 321 Decreased Monocyte ActivationWith Daily Acyclovir Use in HIV-1/HSV-2 CoinfectedWomen Andrew D. Redd 1 ; Kevin Newell 2 ; Eshan U. Patel 1 ; Fred Nalugoda 3 ; Paschal Ssebbowa 3 ; Sarah Kaliballa 3 ; Ronald H. Gray 4 ;Thomas C. Quinn 1 ; David Serwadda 5 ; Steven J. Reynolds 1 1 National Institute of Allergy and Infectious Diseases (NIAID), Washington, DC, US; 2 Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, US; 3 Rakai Health Sciences Program, Kalisizo, Uganda; 4 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 5 Makerere University College of Health Sciences, Kampala, Uganda 322 Atorvastatin Reduced T-Cell Activation and Exhaustion Among Suboptimal Immune Responders: A Randomized Crossover Placebo Controlled Trial Damalie Nakanjako Makerere University Infectious Diseases Institute, Kampala, Uganda 323 P2X Type Purinergic Antagonists Can Block HIV-1 Infection and Associated Inflammation Talia Swartz ; Meagan O’Brien; Anthony Esposito; Nina Bhardwaj; Benjamin Chen Icahn School of Medicine at Mount Sinai, New York, NY, US 2:30 pm– 4:00 pm Pathogenesis in Lymph Nodes 324 CD4 + T cell death mediated by pyroptosis in early SIV infected lymphatic tissues Wuxun Lu 1 ; Guobin Kang 1 ; Fangrui Ma 1 ;YanminWan 2 ;Yue Li 1 ; Mark Lewis 3 ; Qingsheng Li 1 1 University of Nebraska-Lincoln, Lincoln, NE, US; 2 Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, China; 3 BIOQUAL, Inc., Rockville, MD, US 325 Fibrosis in Lymphoid Tissue Is AssociatedWith Peripheral Blood Regulatory T Cells Julie C. Gaardbo 1 ; Patricia S. Nielsen 2 ; Lise Mette R. Gjerdrum 3 ; Karoline Springborg 4 ; Elisabeth Ralfkiær 4 ; Henrik Ullum 4 ; Åse Andersen 4 ; Susanne D. Poulsen 4 Dr. Susanne D Poulsen, sdn@dadlnet.dk 1 University of Copenhagen, Rigshospitalet, Copenhagen, Denmark; 2 Aarhus University Hospital, Denmark, Aarhus, Denmark; 3 Bispebjerg Hospital, University Hospital of Copenhagen, Denmark, Copenhagen, Denmark; 4 Rigshospitalet, University of Copenhagen, Copenhagen, Denmark THURSDAY, FEBRUARY 26, 2015 Session P-C12 Poster Session Poster Hall

2:30 pm– 4:00 pm Dissecting Pathogenesis Through In Vitro Studies 327 A Dual-Tropic HIV-1 Env Interacts With CCR5 to Deplete Bystander CD4 T Cells In Vitro and In Vivo Li-Chung Tsao 1 ; Haitao Guo 2 ; Jerry Jeffrey 3 ; James A. Hoxie 4 ; Lishan Su 2 1 University of North Carolina, Carrboro, NC, US; 2 University of North Carolina, Chapel Hill, NC, US; 3 GSK, Chapel Hill, NC, US; 4 University of Pennsylvania, Philadelphia, PA, US 328 Investigation of the Association of Gag-Protease Dependent Replication Capacities With Clinical Outcomes of HIV-1 Infection Keiko Sakai 1 ;Takayuki Chikata 1 ; Hiroyuki Gatanaga 2 ; Shinichi Oka 2 ; MasafumiTakiguchi 1 1 Kumamoto University, Kumamoto-shi, Japan; 2 National Center for Global Health and Medicine, Tokyo, Japan 329 Association of Bacteria-Induced IL-23 and Th17 Frequencies in HIV-1 + Individuals Jennifer Manuzak 1 ; Sonia Amraoui 1 ; Nipa Decroix 2 ; Pierre Loulergue 2 ; Odile Launay 2 ; Marco Iannetta 1 ; Jean-Baptiste Guillerme 1 ; LeneVimeux 1 ; Anne Hosmalin 1 1 Inserm U1016, Institut Cochin, Paris, France; 2 Centre d’Investigation Clinique CIC 1417, Inserm- AP-HP, Hôpital Cochin, Paris, France 330 Effect of Methamphetamine Use on T-Cell Proliferation In Vivo and Ex Vivo Marta Massanella 4 ; Sara Gianella 4 ; Jennifer M. Dan 1 ; Eric Daar 2 ; Michael P. Dube 3 ; Richard H. Haubrich 4 ; Douglas D. Richman 4 ; Davey M. Smith 4 ; Sheldon Morris 4 ; Rachel D. Schrier 4 1 La Jolla Institute of Allergy and Immunology, La Jolla, CA, US; 2 Los Angeles Biomedical Research Institute at Harbor–University of California Los Angeles Medical Center, Torrance, CA, US; 3 University of Southern California Keck School of Medicine, Los Angeles, CA, US; 4 University of California San Diego, La Jolla, CA, US 2:30 pm– 4:00 pm Dissecting Pathogenesis Through In Vivo Studies 331 A Random Forest Approach to Define Immunological Thresholds for CD4 Recovery in HIV-Treated Individuals Josué Pérez-Santiago 1 ; Marta Massanella 1 ; Dan Ouchi 2 ; Elisabet Gómez 2 ; Cecilia Cabrera 2 ; Bonaventura Clotet 3 ; Eugenia Negredo 3 ; Julià Blanco 2 1 University of California San Diego, La Jolla, CA, US; 2 IrsiCaixa Institute for AIDS Research, Badalona, Spain; 3 Lluita Contra la Sida Foundation, Germans Trias i Pujol University Hospital, Badalona, Spain 332 Disease Progression in HIV Controllers; Uptake and Outcome of Antiretroviral Therapy Jane R. Deayton 1 ; Katherine C. Groves 2 ; David F. Bibby 2 ; Duncan A. Clark 2 ; Iain Reeves 3 ; Jane Anderson 3 ; Chloe M. Orkin 4 ; Eithne O’Sullivan 1 ; Áine McKnight 1 1 Barts and the London, Que, London, United Kingdom; 2 Barts Health NHS Trust, London, United Kingdom; 3 Homerton University Hospital NHS Foundation Trust, London, United Kingdom; 4 Barts Health NHS Trust, London, United Kingdom Session P-C14 Poster Session Poster Hall Nicolas Noel 1 ; Nathalie Lerolle 1 ; Camille Lecuroux 2 ; Cécile Goujard 1 ; AlainVenet 2 ; Asier Sáez- Cirión 3 ;Véronique Avettand-Fenoel 4 ; Laurence Meyer 5 ; Faroudy Boufassa 5 ; Olivier Lambotte 1 ANRS CO21/CODEX Study Group 1 APHP, Service de Médecine Interne et Immunologie Clinique, Hôpital Bicêtre, Le Kremlin-Bicêtre, France, Le Kremlin Bicêtre, France; 2 Inserm U1012, Régulation de la Réponse Immune, Infection VIH1 et Autoimmunité, Le Kremlin Bicêtre, France; 3 Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France; 4 APHP, Service de Virologie, Hôpital Necker – Enfants Malades, Paris, France; 5 Inserm U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Université Paris Sud, Le Kremlin-Bicêtre, France 334 HIV Replication History Is AssociatedWith Plasma IL-7 Levels in Aviremic Youths Daniel Scott-Algara 1 ; Jerome Lechenadec 2 ; JosianeWarszawski 2 ;Thomas Montange 1 ; Jean- PaulViard 3 ; Catherine Dollfus 3 ;Véronique Avettand-Fenoel 4 ; Christine Rouzioux 4 ; Stéphane Blanche 3 ; Florence Buseyne 1 1 Institut Pasteur, Paris, France; 2 Inserm, Le Kremlin-Bicêtre, France; 3 AP-HP, Paris, France; 4 Université Paris Descartes, Paris, France 333 Immunological and Virological Progression in HIV Controllers

Poster Listings

326 Decreased T FR /T FH

Ratio in SIV-Infected Rhesus Macaques Ankita Chowdhury ; Perla Del Río-Estrada; Steven Bosinger; Guido Silvestri Emory University, Atlanta, GA, US

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CROI 2015