CROI 2015 Program and Abstracts

Poster Listings

201 The Activity of HIV-1 Rev/RRE Varies Greatly Between Isolates Patrick E. Jackson 1 ; DenisTebit 1 ; David Rekosh 1 ; Marie-Louise Hammarskjold 1

210 Hyaluronan Reduces HIV Infection of CD4+ T Cells and Greatly Enhances HIV Inhibition by Tenofovir Peilin Li ; Katsuya Fujimoto; Lilly Bourguignon; StevenYukl; Steven Deeks; Philipp Kaiser; Peggy Kim; Diane Havlir; Harry Lampiris; Joseph K.Wong University of California San Francisco, San Francisco, CA, US 211 Alpha-defensins increase HIV transcytosis: role in STI-mediated enhanced HIV transmission Kimyata B. Valere 1 ; Aprille Rapista 1 ; Alison Quayle 2 ;Wuyan Lu 3 ; Eliseo Eugenin 1 ;Theresa Chang 1 1 Rutgers University-New Jersey Medical School, Willingboro, NJ, US; 2 University Health Science Center, New Orleans, LA, US; 3 University of Maryland School of Medicine, Baltimore, MD, US 212 The Design and Investigation of Mechanism of Novel Potent HIV-1 Entry Inhibitor SC12 Marina Tuyishime ; Simon Cocklin Drexel University College of Medicine, Philadelphia, PA, US 213 Optimization of vCCL2-Based CXCR4 Inhibitors by Phage Display and Rational Design Virginie Fievez 1 ; Martyna Szpakowska 1 ; Karthik Arumugam 1 ; Amor Mosbah 2 ; Sabrina Deroo 1 ; Xavier Dervillez 1 ; Pierre-Arnaud Gauthier 1 ; Michele Baudy-Floc’h 2 ; Carole Devaux 1 ; Andy Chevigné 1 1 CRP-sante, Laboratory of Retrovirology, 84 Rue Val Fleuri, 1526 Luxembourg, Luxembourg; 2 Université de Rennes 1, UMR CNRS 6226, Avenue du Général Leclerc, 35042 Rennes, France 214 HIV-1 Infection of Female Primary Genital Epithelial Cells After PseudotypingWith HTLV-1: Potential Driver of Sexual Transmission of HIV-1 Yuyang Tang 1 ; Alvin George 1 ; Oksana Petrechko 1 ; Brian Imbiakha 1 ; Stephanie Sweet 1 ; YuetsuTanaka 2 ; Franklin Nouvet 1 ; James E. Hildreth 1 1 University of California Davis, Davis, CA, US; 2 University of the Ryukyus, Nishihara-cho, Japan 2:30 pm– 4:00 pm Envelopes, Receptors, and Tropism 215 Evaluation of HIV-1 Clones for Unique Properties AssociatedWith Transmission Katja Klein 1 ; Annette Ratcliff 2 ; Gabrielle Nickel 2 ; Immaculate Nankya 2 ; Mike Lobritz 2 ;Yong Gao 2 ; Robin Shattock 3 ; Eric J. Arts 1 1 University of Western Ontario, London, Canada; 2 Case Western Reserve University, Cleveland, OH, US; 3 Imperial College London, London, United Kingdom 216 Selection of HIV Env Mutants With Altered Trimers by EMPIRIC Saturation Mutagenesis Maria Duenas-Decamp ; Li Jiang; Dan Bolon; Paul R. Clapham University of Massachusetts Medical School, Worcester, MA, US 217 Characterization of HIV-1 Envelopes in Acutely and Chronically Infected Injection Drug Users Behzad Etemad 1 ; Oscar A. Gonzalez 1 ; Laura F.White 2 ; Oliver B. Laeyendecker 3 ; Greg D. Kirk 3 ; Shruti Mehta 3 ; Manish Sagar 1 1 Boston University School of Medicine, Boston, MA, US; 2 Boston University, Boston, MA, US; 3 Johns Hopkins University, Baltimore, MD, US 218 Phenotypic Characterization of Transmitted/Founder Virus in HIV-1 Transmission Pairs Corinna S. Oberle 1 ; Beda Joos 1 ; Nottania K. Campbell 1 ; David Beauparlant 1 ; Herbert Kuster 1 ; Corinne Schenkel 1 ; Peter Rusert 1 ; AlexandraTrkola 1 ; Karin J. Metzner 1 ; Huldrych F. Günthard 1 1 University Hospital Zurich, Zurich, Switzerland; 2 Institute of Medical Virology, Zurich, Switzerland WEDNESDAY, FEBRUARY 25, 2015 Session P-A5 Poster Session

1 University of Virginia, Charlottesville, VA, US; 2 University of Virginia, Charlottesville, VA, US

TUESDAY, FEBRUARY 24, 2015 Session P-A3 Poster Session

Poster Hall

2:30 pm– 4:00 pm SAMHD1 202 A Surprising New Function of SAMHD1 as a Pro-Pathogenic Factor in HIV Infection Gilad Doitsh ; Nicole Galloway; Xin Geng; Isa Monus Arias; ZhiyuanYang;Warner C. Greene The J. David Gladstone Institute, University of California San Francisco, San Francisco, CA, US 203 Mapping Vpx and Vpr Specificity in Antagonism of SAMHD1 Chelsea Spragg ; Michael Emerman Fred Hutchinson Cancer Research Center, Seattle, WA, US 204 Differentiation Stimuli Strongly Impact the Ability of Macrophages to Support HIV-1 Replication Due to SAMHD1 Restriction Ester Ballana 1 ; Roger Badia 1 ; Eva Riveira-Muñoz 1 ; Alba Ruíz 1 ; JavierTorres-Torronteras 2 ; Bonaventura Clotet 1 ; Eduardo Pauls 1 ; Ramon Marti 2 ; José Esté 1 HIV Pathogenesis Research Group 1 IrsiCaixa Institute for AIDS Research, Badalona, Spain; 2 Institut de Recerca Hospital Universitari Vall d’Hebron, Barcelona, Spain 205 Essential Role of Cyclin D3 in dNTP Pool Control and HIV-1 Replication in Macrophages Ester Ballana 1 ; Alba Ruíz 1 ; Eduardo Pauls 1 ; JavierTorres-Torronteras 2 ; Roger Badia 1 ; Eva Riveira-Muñoz 1 ; Bonaventura Clotet 1 ; Ramon Marti 2 ; José Esté 1 HIV Pathogenesis Research Group 1 IrsiCaixa Institute for AIDS Research, Badalona, Spain; 2 Institut de Recerca Hospital Universitari Vall d’Hebron, Badalona, Spain 206 Low SAMHD1 Expression Renders Activated and Proliferated CD4 + Susceptible to HIV-1 Nabila Seddiki 1 ; Nicolas Ruffin 1 ;Vedran Brezar 1 ; Diana Ayinde 2 ; Julian Schulze zurWiesch 3 ; Jan van Lunzen 3 ; Olivier Schwartz 2 ; Jean-Daniel Lelièvre 1 ; Jacques Banchereau 1 ;Yves Lévy 1 1 Inserm U955 Eq16/UPEC, Créteil, France; 2 Institut Pasteur, Paris, France; 3 University Medical Center, Hamburg-Eppendorf and Heinrich-Pette-Institute, Hamburg, Germany 207 SAMHD1 Partially Blocks Lentiviral Gene Transfer Into Hematopoietic Stem Cells Duo Li 1 ; Erika Schlaepfer 1 ; Annette Audigé 1 ; Baek Kim 2 ; Roberto Speck 1 1 University Hospital Zurich, Zurich, Switzerland; 2 Department of Pediatrics Emory School of Medicine, Atlanta, GA, US 2:30 pm– 4:00 pm Enhancers and Inhibitors of Viral Infectivity and Entry 208 Fresh Semen Harbors HIV-Enhancing Amyloids and Decreases the Efficacy of Microbicides Jan Munch 3 ; Onofrio Zirafi 3 ; Shariq Usmani 3 ; Kyeong-Ae Kim 3 ; Frank Kirchhoff 3 ; Christopher D. Pilcher 1 ; Haichuan Liu 1 ; H. EwaWitkowska 1 ;Warner C. Greene 2 ; Nadia R. Roan 1 1 University of California San Francisco, San Francisco, CA, US; 2 The J. David Gladstone Institutes, San Francisco, CA, US; 3 Ulm University Medical Center, Ulm, Germany 209 Semen’s HIV Enhancing Activity Is an Individual Characteristic Independent of VL Christopher D. Pilcher ;Teri Liegler; Jason Neidleman; H. EwaWitkowska;Wendy Hartogensis; Kara Marson; Peter Bacchetti; Frederick M. Hecht;Warner C. Greene; Nadia R. Roan University of California San Francisco, San Francisco, CA, US THURSDAY, FEBRUARY 26, 2015 Session P-A4 Poster Session Poster Hall

Poster Listings

Poster Hall

25

CROI 2015