CROI 2015 Program and Abstracts

Poster Listings

Session P-B1 Poster Session

Poster Hall

219 HIV Coreceptor Tropism Switching Is CorrelatedWith Binding Affinity to CXCR4 Homero Vazquez 1 ; Antoine Chaillon 2 ; Douglas D. Richman 3 ; Sara GianellaWeibel 1 ; Gabriel Wagner 1 ; David M. Smith 3 1 University of California San Diego, San Diego, CA, US; 2 Inserm UMR U966, Tours, France; 3 Veterans Affairs Medical Center, San Diego, CA, US 220 Selective Cell-Free or Cell-to-Cell HIV-1 Infection by gp41 Cytoplasmic Tail Mutants Natasha D. Durham 1 ; Benjamin K. Chen 1 1 Icahn School of Medicine at Mount Sinai, New York, NY, US; 2 Icahn School of Medicine at Mount Sinai, New York, NY, US 221 Analysis of Viral Evolution in the Blood Reveals Potential Insight Into the Evolution of Macrophage Tropism Maria M. Bednar 1 ; LiHua Ping 1 ; Kathryn Arrildt 1 ; Christa Sturdevant 2 ; Sarah B. Joseph 1 ; Laura Kincer 1 ; Celia LaBranche 2 ; David Montefiori 2 ; Myron Cohen 3 ; Ronald Swanstrom 1 1 University of North Carolina, Durham, NC, US; 2 Duke University, Durham, NC, US; 3 University of North Carolina, Chapel Hill, NC, US 222 Mechanistic Differences in Interactions of HIV-1 and HIV-2With Dendritic Cells Suzanne D. Kijewski ; Hisashi Akiyama; Caitlin Miller; Nora P. Ramirez; Rahm Gummuluru Boston University School of Medicine, Boston, MA, US 223 Identification of the First Nonhuman Primate CD4 Receptor for T/F HIV-1 Isolates Nicholas Meyerson 2 ; Amit Sharma 1 ; GregoryWilkerson 3 ; Julie M. Overbaugh 1 ; Sara Sawyer 2 1 Fred Hutchinson Cancer Research Center, Seattle, WA, US; 2 The University of Texas at Austin, Austin, TX, US; 3 University of Texas, MD Anderson Cancer Center, Bastrop, TX, US 224LB Vpr Increases Env Spikes on Virions to Enhance HIV-1 Replication in Nondividing Myeloid Cells Tao Zhou 1 ; Xianfeng Zhang 2 ; Yonghui Zheng 1 1 Michigan State University, East Lansing, MI, US; 2 Harbin Veterinary Research Institute, Harbin, China 2:30 pm– 4:00 pm Nef Functions 225 Env and Nef Cooperatively Contribute to HIV-1 – Induced pDC Activation via CD4-Dependent Mechanisms Natalia J. Reszka-Blanco 1 ;Vijay Sivaraman 1 ; Liguo Zhang 2 ; Lishan Su 1 1 University of North Carolina, Chapel Hill, NC, US; 2 Key Lab of Infection and Immunity, Insitute of Biophysics, Chinese Academy of Science, Beijing, China 226 Naturally Occurring Polymorphisms in HIV-1 Nef Impair Its Functions and Decrease Viral Replication Capacity Thomas Vollbrecht 2 ; Lorelei Bornfleth 1 ; Patricia Frohnen 1 ; Martha J. Lewis 1 1 David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, US; 2 University of California San Diego (UCSD), La Jolla, CA, US 227 Dynamic Range of Down-Regulation of HIV-1 Entry Receptors by Primary Nef Isolates Mako Toyoda 1 ;Yoko Ogata 1 ; Macdonald Mahiti 1 ; Florencia Pereyra 3 ;Toshiyuki Miura 2 ; Bruce Walker 3 ; Zabrina L. Brumme 4 ; Mark A. Brockman 4 ;Takamasa Ueno 1 1 Kumamoto University, Kumamoto, Japan; 2 University of Tokyo, Tokyo, Japan; 3 Ragon Institute of MGH, MIT and Harvard University, Cambridge, MA, US; 4 Simon Fraser University, Burnaby, Canada 228 Differential Down-Regulation of HLA Class I Allotypes by HIV-1 Nef Primary Isolates Macdonald Mahiti 1 ; Xiaofei Jia 2 ; MakoToyoda 1 ; Francis Mwimanzi 1 ; BruceWalker 3 ; Zabrina L. Brumme 4 ; Mark Brockman 4 ;Yong Xiong 2 ; Takamasa Ueno 1 1 Kumamoto University, Kumamoto, Japan; 2 Yale University, New Haven, CT, US; 3 Ragon Institute of MGH, MIT and Harvard University, Boston, MA, US; 4 Simon Fraser University, Burnaby, Canada THURSDAY, FEBRUARY 26, 2015 Session P-A6 Poster Session Poster Hall

2:30 pm– 4:00 pm Viral Origins and Recombinant Forms 229 Geopolitical Effects in the Epidemiology of HIV-1 Subtype

Gkikas Magiorkinis 2 ; Kostantinos Angelis 1 ; Ioannis Mamais 1 ; Angelos Hatzakis 1 ; Jan Albert 3 ; Glenn Lawyer 4 ; AnnemarieWensing 5 ; Charles Boucher 6 ; Anne-MiekeVandamme 7 ; Dimitrios Paraskevis 1 1 University of Athens, Athens, Greece; 2 University of Oxford, Oxford, United Kingdom; 3 Karolinska Institutet, Stockholm, Sweden; 4 Max Planck Institute for Informatics, Saarbrücken, Germany; 5 University Medical Center Utrecht, Utrecht, Netherlands; 6 Erasmus University Medical Center, Rotterdam, Netherlands; 7 KU Leuven, Leuven, Belgium Marie Leoz 1 ; Felix Feyertag 2 ; Anfumbom Kfutwah 3 ; Philippe Mauclere 4 ; Guillaume Lachenal 5 ; Florence Damond 6 ;Veronique Lemee 1 ; Francois Simon 7 ; David Robertson 2 ; Jean- Christophe Plantier 1 1 University Hospital Rouen, Rouen, France; 2 Manchester University, Manchester, United Kingdom; 3 Centre Pasteur du Cameroun, Yaounde, Cameroon; 4 Direction Interarmées du Service de Santé, Noumea, New Caledonia; 5 Université Paris Diderot, Paris, France; 6 APHP CHU Bichat Claude Bernard, Paris, France; 7 APHP CHU Saint Louis, Paris, France 231 Evidence for More Major HIV-1M Lineages From the Early Stages of the HIV-1 Epidemic Marcel Tongo Passo 1 ;Wendy A. Burgers 2 ; Eitel Mpoudi-Ngole 3 ; Jeffrey Dorfman 1 ; Darren P. Martin 4 1 International Center for Genetic Engineering and Biotechnology, Cape Town, Cape Town, South Africa; 2 Division of Medical Virology, University of Cape Town, Cape Town, South Africa; 3 Institute of Medical Research and Study of Medicinal Plants (IMPM), Yaoundé, Cameroon, Yaounde, Cameroon; 4 Computational Biology Group, University of Cape Town, Cape Town, South Africa 232 HIV-1/M+O Dual Infections and HIV-MO Recombinants in France From 2004 to 2014 Pierre Cappy 1 ; Fabienne De Oliveira 1 ;Veronique Lemee 1 ; Jean-Louis Gaillard 2 ; Laurence Bocquet 3 ; Jean-Dominique Poveda 4 ; Magali Bouvier 5 ; Anne Maillard 6 ; Thomas Mourez 1 ; Jean-Christophe Plantier 1 1 Rouen University Hospital, Rouen, France; 2 Ambroise Paré Hospital, Paris, France; 3 Lille University Hospital, Lille, France; 4 CERBA Laboratory, Saint-Ouen L’Aumone, France; 5 Henri Mondor Hospital, Créteil, France; 6 Pontchaillou Hospital, Rennes, France 233 Evidence of Intra-Familial Transmission of an HIV-1 M/O Intergroup Recombinant Virus Paul Alain T. Ngoupo 1 ; Serge Alain Sadeuh-Mba 1 ; Fabienne De Oliveira 2 ;Valérie Ngono 1 ; Laure Ngono 1 ; PatriceTchendjou 4 ;Véronique Penlap Mbeng 3 ; Richard Njouom 1 ; Anfumbom Kfutwah 1 ; Jean-Christophe Plantier 2 1 Centre Pasteur of Cameroon, Yaounde, Cameroon; 2 Virology, CHU Rouen, Rouen, France; 3 University of Yaounde I, Yaounde, Cameroon; 4 Epidemiology, Centre Pasteur of Cameroon, Yaounde, Cameroon 234 Searching for Rare HIV Strains in Rural Democratic Republic of Congo (2001–2003) Ana S. Vallari 1 ; Carole McArthur 2 ; Larry Sthreshley 3 ; Catherine Brennan 1 1 Abbott Laboratories, Chicago, IL, US; 2 University of Missouri–Kansas City, Kansas City, MO, US; 3 IMA World Health, Kinshasa, Congo (the Democratic Republic of the) 235 Clinical and Virological Characterization of CRF07_BC infection Szu-Wei Huang 1 ; Sheng-FanWang 1 ; Chih-Hao Lee 1 ;Wing-WaiWong 2 ; Hung-ChinTsai 3 ; Chia-JuiYang 4 ; Chin-TienWang 5 ; Jaang-JiunWang 6 ; Daniel Kuritzkes 7 ;Yi-Ming A. Chen 1 1 Kaohsiung Medical University, Kaohsiung City, Taiwan; 2 Taipei Veterans’ General Hospital, Taipei, Taiwan; 3 Kaohsiung Veterans’ General Hospital, Kaohsiung City, Taiwan; 4 Far Eastern Memorial Hospital, New Taipei City, Taiwan; 5 National Yang-Ming University, Taipei, Taiwan; 6 Children’s Healthcare of Atlanta and Emory University School of Medicine, Atlanta, GA, US; 7 Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, US 236 Reconstructing the HIV-1 Epidemics in Burkina Faso Using Early Samples Gonzalo Yebra 1 ; Marcia L. Kalish 2 ; Andrew J. Leigh Brown 1 1 University of Edinburgh, Edinburgh, United Kingdom; 2 Vanderbilt University, Nashville, TN, US 230 The 2 Phases of HIV-1 Group O Diversification

Poster Listings

26

CROI 2015