CROI 2015 Program and Abstracts

Poster Listings

POSTER LISTINGS, BY CATEGORY

192 HIV and SIV Inhibition by RNA-Associated Early Stage Antiviral Factor (REAF) Aine McKnight Queen Mary University of London, London, United Kingdom 193 Translational Control of APOBEC3G/F Restriction Factors by the HIV-1 Vif Protein Camille Libre 1 ; Santiago X. Guerrero 2 ; Julien Batisse 1 ; Roland Marquet 1 ; Jean-Christophe Paillart 1 1 IBMC CNRS, Strasbourg, France; 2 Centre for Genomic Regulation, Barcelona, Spain 194 Evidence for Lentivirus-Driven Evolution of APOBEC3C CristinaWittkopp ; Michael Emerman Fred Hutchinson Cancer Research Center, Seattle, WA, US 195 Reevaluation of the Role of the Small Host Cell GTPase Rab6 in the HIV-1 Replication Cycle Isaac Zentner ; Simon Cocklin Drexel University College of Medicine, Philadelphia, PA, US 2:30 pm– 4:00 pm Nucleus Entry, Integration, and Export 196 The Mutated Form of Transportin 3 From Patients With Limb-Girdle Muscular Dystrophy 1F Hijacks Wild-Type Transportin 3 and Interferes With CPSF6 Subcellular Localization, Impairing HIV-1 Nuclear Entry Sara Rodriguez-Mora 1 ; Mayte Coiras 1 ; Mercedes Bermejo 1 ; Elena Mateos 1 ; Ramon Marti 2 ; Juan JesusVilchez 3 ; Antonio Luis Andreu 2 ; Jose Alcami 1 On behalf of the AIDS Immunopathogenesis Unit 1 Instituto de Salud Carlos III, Madrid, Spain; 2 Vall d’Hebron Institut de Recerca, Barcelona, Spain; 3 Hospital Universitari i Politecnic La Fe, Valencia, Spain 197 Longitudinal Epigenome-Wide Association Study of Pre- and Post-HIV – I nfected Subjects Sophie Limou 1 ; GeorgeW. Nelson 1 ; Elizabeth Binns-Roemer 1 ; Jia Li 1 ; Fathi Elloumi 1 ; James J. Goedert 3 ; Cheryl A.Winkler 1 1 Frederick National Laboratory Operated by Leidos Biomedical Research, Inc, for the National Cancer Institute, Frederick, MD, US; 2 Frederick National Laboratory Operated by Leidos Biomedical Research, Inc, for the National Cancer Institute, Frederick, MD, US; 3 National Cancer Institute (NCI), Bethesda, MD, US 198 IN Variants Retarget HIV-1 Integration and Are AssociatedWith Disease Progression Frauke Christ 1 ; Jonas Demeulemeester 1 ; Zeger Debyser 1 ; Rik Gijsbers 1 ; Jan De Rijck 1 ; Thumbi Ndung’u 2 ; Paradise Madlala 1 1 KU Leuven, Leuven, Belgium; 2 University of KwaZulu-Natal, Durban, South Africa 199 HIV-1 Integration Sites in Macrophages and CD4 + T Cells Are Distinct Yik Lim Kok ;ValentinaVongrad; Mohaned Shilaih; Herbert Kuster; Roger Kouyos; Huldrych F. Günthard; Karin J. Metzner University Hospital Zurich, Zurich, Switzerland 200 A Screening for DNA Repair Enzymes That Affect HIV-1 Infection Noriyoshi Yoshinaga 1 ;Yusuke Matsui 1 ; Keisuke Shindo 1 ; shunichiTakeda 1 ; AkifumiTakaori- Kondo 1 1 Kyoto University, Kyoto-shi, Japan; 2 Kyoto University, Kyoto-shi, Japan WEDNESDAY, FEBRUARY 25, 2015 Session P-A2 Poster Session Poster Hall

TUESDAY, FEBRUARY 24, 2015 Session P-A1 Poster Session

Poster Hall

2:30 pm– 4:00 pm Cellular Innate Immunity 183 STAT5 Inhibition Reduces HIV-1 Infection and TLR7/8 Responses in Human Macrophages Sofia Appelberg 1 ; Carla N. Mavian 1 ; Julie C.Williams 1 ; Philip Lichlyter 1 ; John Sleasman 2 ; Maureen M. Goodenow 2 1 University of Florida, Gainesville, FL, US; 2 Duke University, Durham, NC, US 184 Regulation of the Innate Immune Sensing of HIV by the Viral Capsid and the Cytosolic DNA Sensor cGAS Nicolas Manel Institut Curie, Paris, France 185 cGAS Induced Type I IFN Responses in Dendritic Cells FromHIV Elite Controllers Enrique Martin-Gayo 1 ; Jacqueline Cronin 1 ; Zhengyu Ouyang 1 ;Taylor Hickman 1 ; John Trombetta 2 ; Florencia Pereyra 1 ; BruceWalker 1 ; Alex Shalek 1 ; Mathias Lichterfeld 3 ; XuYu 1 1 Ragon Institute of MIT, MGH and Harvard, Boston, MA, US; 2 MIT Institute for Medical Engineering & Science, Boston, MA, US; 3 Massachusetts General Hospital, Boston, MA, US 186 Characterization of Interferon- α Subtypes in the LPAC Model Michael Harper 1 ; Kathrin Gibbert 2 ; Eric Lee 1 ; Kejun Guo 1 ; Stephanie Dillon 1 ; Martin McCarter 3 ; Ulf Dittmer 2 ; Cara C.Wilson 1 ; Mario Santiago 1 1 University of Colorado Anschutz Medical Campus, Denver, CO, US; 2 University of Duisburg- Essen, Essen, Germany; 3 University of Colorado Anschutz Medical Campus, Aurora, CO, US 187 HIV Vpu Inhibits NF-kB Activity but Does Not InterfereWith Interferon Regulatory Factor 3 Lara Manganaro ; Elisa de Castro; Ana Maestre; Adolfo Garcia-Sastre; Ana Fernandez- Sesma;Viviana A. Simon Icahn School of Medicine at Mount Sinai, New York, NY, US 188 HIV-1 Exploits CD169 to Evade IFN α -Induced Antiviral State in Myeloid Cells Hisashi Akiyama 1 ; Nora Ramirez 1 ; Gregory Gibson 2 ; SimonWatkins 2 ; Zandrea Ambrose 2 ; Rahm Gummuluru 1 1 Boston University School of Medicine, Boston, MA, US; 2 University of Pittsburgh School of Medicine, Pittsburgh, PA, US; 3 University of Pittsburgh School of Medicine, Pittsburgh, PA, US 189 Interferon-Induced Transmembrane Proteins (IFITMs) Antagonize Postintegration Replication of HIV but Are Overcome by Viral Membrane Accessory Proteins Wingyiu Lee ; Ifrah Omar; Richard D. Sloan Queen Mary University of London, London, United Kingdom 190 HSV-1-Induced Enhancement of HIV-1 Replication Is Dependent on Decrease in IFITM3 Levels Viviane Andrade 1 ; Milene Miranda 2 ; Mario Stevenson 1 ;Thiago M. Souza 2 1 University of Miami, Miami, FL, US; 2 Oswaldo Cruz Foundation, Rio de Janeiro, Brazil 191 Characterization of the Activity of an Innate Immunity Protein, the Apolipoprotein L6 Nitisha Pyndiah 1 ; Angela Ciuffi 1 ; AmalioTelenti 2 1 Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 2 J Craig Venter Institute, San Diego, CA, US

Poster Listings

24

CROI 2015