CROI 2015 Program and Abstracts

Oral Sessions

32 Most BreastfeedingWomenWith High Viral Load Are Still Undiagnosed in Sub-Saharan Africa David Maman 1 ; Helena Huerga 1 ; Irene Mukui 4 ; Benson Chilima 2 ; Beatrice Kirubi 5 ; GillesVan Cutsem 6 ; Charles Masiku 7 ; Elisabeth Szumilin 8 ;Thomas Ellman 3 ; Jean-François Etard 1 1 Epicentre/Médecins Sans Frontières, Paris, France; 2 3. Ministry of Health, Lilongwe, Malawi; 3 Medecins Sans Frontières, Cape Town, South Africa; 4 National AIDS and STDs Control Program, Nairobi, Kenya; 5 Médecins Sans Frontières, Nairobi, Kenya; 6 Médecins Sans Frontières, Cape Town, South Africa; 7 Médecins Sans Frontières, Lilongwe, Malawi; 8 Médecins Sans Frontières, Paris, France 33 Delayed HIV Detection in Infants Exposed to ARV Prophylaxis During Breastfeeding Caroline C. King 1 ; Julie A. Nelson 2 ; Carrie Ziemniak 3 ; Michael G. Hudgens 2 ; GeraldTegha 4 ; Charles S. Chasela 5 ; Denise J. Jamieson 1 ; Deborah Persaud 3 ; Charles M. van der Horst 2 ; Athena P. Kourtis 1 1 US Centers for Disease Control and Prevention (CDC), Atlanta, GA, US; 2 University of North Carolina at Chapel Hill, Chapel Hill, NC, US; 3 Johns Hopkins University, Baltimore, MD, US; 4 UNC Project, Lilongwe, Malawi; 5 University of Witwatersrand, Johannesburg, South Africa 34 Evaluation of the Alere q for Point-of-Care Early Infant HIV Diagnosis in South Africa Nei-Yuan Hsiao 1 ; Max Kroon 2 ; Lorna Dunning 2 ; Landon Myer 2 1 University of Cape Town, Cape Town, South Africa; 2 University of Cape Town, Cape Town, South Africa 35 Early ART and Sustained Virological Suppression Limits HIV Proviral DNA Reservoir: CHER Evidence Helen A. Payne 1 ; SarahWatters 1 ; Marvin Hsaio 2 ; Robin Callard 1 ; Abdel Babiker 3 ; Mark F. Cotton 4 ; Kennedy Otwombe 5 ; AvyViolari 5 ; Diana M. Gibb 3 ; Nigel J. Klein 1 1 University College London, London, United Kingdom; 2 University of Cape Town, Cape Town, South Africa; 3 MRC Clinical Trials Unit at University College London, London, United Kingdom; 4 Stellenbosch University, Cape Town, South Africa; 5 University of Witswatersrand, Johannesburg, South Africa 36 Long-Term Outcomes of HIV-Infected Children Initiating NVP vs LPV/r- Based Treatment Linda Barlow-Mosha 1 ; Konstantia Angelidou 2 ; Moherndran Archary 8 ; AvyViolari 7 ; Jane Lindsey 2 ; Lynne Mofenson 3 ; Patrick Jean-Philipe 5 ; Paul E Palumbo 4 ; Benjamin Chi 6 On behalf of the IMPAACT P1060 ProtocolTeam 1 Makerere University–Johns Hopkins University Research Collaboration, Kampala, Uganda; 2 Harvard School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA, US; 3 National Institutes of Health, Bethesda, MD, US; 4 Geisel School of Medicine at Dartmouth, Lebanon, NH, US; 5 Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD, US; 6 University of North Carolina at Chapel Hill, Chapel Hill, NC, US; 7 University of Witswatersrand, Johannesburg, South Africa; 8 University of KwaZulu-Natal, Durban, South Africa; 9 IMPAACT, SilverSpring, MD, US 37 Structural Cardiovascular Changes Are Reversible in HIV-Infected Children in Zambia and Uganda. Julia M. Kenny 1 ; Adrian Cook 1 ; Grace Mirembe 2 ; Dorica Masaku 3 ; PriscillaWavamunno 2 ; Florence Odongo 2 ; Alicja Rapala 1 ; John Deanfield 1 ; Diana M. Gibb 1 ; Nigel J. Klein 1 1 University College London, London, United Kingdom; 2 Joint Clinical Research Centre, Kampala, Uganda; 3 University Teaching Hospital, Lusaka, Zambia 38LB ART WithWeekends Off Is Noninferior to Continuous ART in Young People on EFV+2NRTI Karina M. Butler On behalf of the BREATHERTrialTeam Our Lady’s Children’s Hospital, Dublin, Ireland Session O-3 Oral Abstracts Room 615 10:00 am– 12:00 pm Cellular Dynamics, Sensing, and Viral Restriction Moderators Jaisri Lingappa , University of Washington, Seattle, WA, US Aine McKnight , Queen Mary University of London, London, United Kingdom 39 Envelope Trimer Numbers Required for Entry Steer HIV-1 Infectivity and Entry Kinetics Oliver Brandenberg 2 ; Carsten Magnus 2 ; Peter Rusert 2 ; Roland Regoes 1 ; Alexandra Trkola 2 1 ETH Zurich, Zurich, Switzerland; 2 University of Zurich, Zurich, Switzerland

40 HIV-1 Accessory Protein Function: Evaluating VPU-Dependent Host Factor Degradation Prashant Jain ; Kevin Olivieri; Quy Nguyen; Paul De Jesus; Sumit Chanda Sanford-BurnhamMedical Research Institute, La Jolla, CA, US 41 HIV-1 Adaptation to Humans Involved Interactions of Vpr With the DNA Damage Response Oliver I. Fregoso ; Michael Emerman Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, US 42 The HIV-1 Protease Can Interact With RNA to Dramatically Enhance Its Activity Marc Potempa 1 ; Ellen Nalivaika 2 ; Sook-Kyung Lee 1 ; Celia A. Schiffer 2 ; Ronald Swanstrom 1 1 University of North Carolina, Chapel Hill, NC, US; 2 University of Massachusetts Medical School, Worcester, MA, US 43 PQBP1 Is a Retrovirus-Specific Sensor Mediating cGAS/IRF3-Dependent Innate Responses Sunnie M. Yoh 1 ; Monika Schneider 1 ; Stephen Soonthornvarcharin 1 ; Rana Akleh 1 ; Kevin Olivieri 1 ; Paul De Jesus 1 ; Chunhai Ruan 2 ; Elisa de Castro 3 ; Pedro Ruiz 1 ; Adolfo Garcia-Sastre 3 1 Sanford-BurnhamMedical Research Institute, La Jolla, CA, US; 2 University of Michigan, Ann Arbor, MI, US; 3 Icahn School of Medicine at Mount Sinai, New York, NY, US 44 Mucosal HIV-1 Transmission Specifically Selects for Type 1 Interferon- Resistant Viruses Shilpa Iyer 1 ; Frederic Bibollet-Ruche 1 ; Christiana M. Shaw 1 ;Weiyu Zhang 1 ;Yingying Li 1 ; Timothy Decker 1 ; George M. Shaw 1 ; Persephone Borrow 2 ; Beatrice H. Hahn 1 1 University of Pennsylvania, Philadelphia, PA, US; 2 University of Oxford, London, United Kingdom 45 The Dynamics of HIV-1 RNA Near the Plasma Membrane During Virus Assembly Luca Sardo ; Steven C. Hatch; Jianbo Chen; Olga A. Nikolaitchik; Ryan C. Burdick; De Chen; Christopher J.Westlake; Stephen Lockett;Vinay K. Pathak;Wei-Shau Hu Frederick National Laboratory for Cancer Research, Frederick, MD, US 46LB Mechanisms of Dendritic Cell-Mediated Transfer of HIV-1 to CD4 + T Lymphocytes Mickael M. Menager 1 ;Wendy Lin 1 ; Jarrod S. Johnson 2 ; Kristen Dancel-Manning 1 ; Nicolas Manel 3 ; Feng-Xia Liang 1 ; Dan R. Littman 1 1 Skirball Institute of Biomolecular Medicine, New York, NY, US; 2 Seattle Biomedical Research Institute, Seattle, WA, US; 3 Institut Curie, Paris, France Session O-4 Oral Abstracts Room 6D 10:00 am– 12:15 pm New Discoveries in HIV Pathogenesis Moderators Irini Sereti , National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US Donald Sodora , Seattle Biomed, Seattle, WA, US 47 Inflammation Persists Despite Early Initiation of ART in Acute HIV Infection Netanya S. Utay 1 ; Jintanat Ananworanich 2 ; Suteera Pinyakorn 3 ; Adam Rupert 5 ; Duanghathai Sutthichom 3 ; Suwanna Puttamaswin 3 ; Bonnie M. Slike 2 ; Nelson L. Michael 2 ; Daniel C. Douek 4 ; Irini Sereti 4 1 University of Texas Medical Branch at Galveston, Galveston, TX, US; 2 US Military HIV Research Program, Silver Spring, MD, US; 3 South East Asia Research Collaboration with Hawaii, Bangkok, Thailand; 4 National Institutes of Health (NIH), Frederick, MD, US; 5 Leidos Biomedical Research, Inc, Frederick, MD, US

Tuesday, February 24, 2015 • Oral Sessions

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CROI 2015