CROI 2016 Program at a Glance

Program and Agenda

351 Impact of cART & Systemic inflammation on Semen HIV-1 Reservoir in Primary Infection Antoine Chéret 1 ; Julia Heitzmann 2 ; Adeline Mélard 3 ; Christine Durier 2 ; Ludivine David 3 ; Michaella Muller-Trutwin 4 ; Jean-Marie Chennebault 5 ; Camille Lécuroux 6 ; Christine Rouzioux 7 ; Laurence Meyer 8 ; for the ANRS 147 OPTIPRIMTeam 1 LeKremlin-BicêtreHosp,AP-HP,LeKremlin-Bicêtre,France; 2 INSERM SC10-US19,Villejuif,France; 3 HospNecker,Paris,France; 4 InstPasteur, Paris,France; 5 AngersHosp,Angers,France; 6 INSERMU802,LeKremlin- Bicêtre,France; 7 NeckerHosp,AP-HP,Paris,France; 8 INSERM,CESPU1018, LeKremlin-Bicêtre,France 352 Predictors of Viral Control After ART Interruption in SIV-Infected Rhesus Macaques Luca Micci 1 ; Emily Ryan 2 ; Steven E. Bosinger 2 ; Remi Fromentin 3 ; Rafick Sekaly 4 ; Nicolas Chomont 5 ; Jeffrey Lifson 6 ; Mirko Paiardini 2 1 EmoryUniv,Atlanta,GA,USA; 2 YerkesNatlPrimateRsrCntr,Emory Univ,Atlanta,GA,USA; 3 UnivofMontreal,Montreal,QC,Canada; 4 Case WesternReserveUniv,Cleveland,OH,USA; 5 UnivdeMontréal,Montreal, QC,Canada; 6 FrederickNatlLab,Frederick,MD,USA Francesca Calascibetta 1 ; Luca Micci 1 ; Diane Carnathan 1 ; Benton Lawson 1 ; Ann Chahroudi 2 ; Jeffrey Lifson 3 ; Mirko Paiardini 4 ; Guido Silvestri 4 1 EmoryUniv,Atlanta,GA,USA; 2 EmoryUnivSchofMed,Atlanta,GA, USA; 3 FrederickNatlLab,Frederick,MD,USA; 4 YerkesNatlPrimateRsr Cntr,EmoryUniv,Atlanta,GA,USA 2:45 PM-4:00 PM Approaches to Reactivating HIV and Gene Therapy 354 Bryostatin-1 for Latent-Virus Reactivation: A Phase I, Double-Blind Clinical Trial Carolina Gutiérrez 1 ; Nadia Madrid-Elena 1 ; Sergio Serrano-Villar 1 ; María Jesús Pérez-Elias 2 ; María E. Martín 1 ; Coral Barbas 3 ; Javier Ruperez 3 ; Eduardo Muñoz 4 ;Trevor Castor 5 ; Santiago Moreno 2 1 RamónyCajalHosp, IRYCIS,Madrid,Spain; 2 HospUniversitarioRamón yCajal,Madrid,Spain; 3 CEMBIO,SanPabloCEUUniv,Madrid,Spain, Madrid,Spain; 4 CórdobaUniv,Córdoba,Spain; 5 AphiosCorporation, Boston,MA,USA 355 Clinical Administration of Vorinostat Increases NK Cell Capacity to Produce IFN-g Carolina Garrido ; Natalia Soriano-Sarabia; Brigitte Allard; Katherine Sholtis; Nancie M. Archin; David M. Margolis UnivofNorthCarolinaatChapelHill,ChapelHill,NC,USA 356 CCR5 Gene-Edited Cells Undergo Positive Selection in SHIV-Infected Nonhuman Primates ChristopherW. Peterson 1 ; JianbinWang 2 ; Michael Holmes 2 ; Patricia Polacino 3 ; Shiu-Lok Hu 3 ; Robert Murnane 4 ; Audrey Baldessari 4 ; Hans-Peter Kiem 1 Session P-F5 Poster Abstracts Hall A/B 1 FredHutchinsonCancerRsrCntr,Seattle,WA,USA; 2 SangamoBioScis, Richmond,CA,USA; 3 UnivofWashington,Seattle,WA,USA; 4 Washington NatlPrimateRsrCntr,Seattle,WA,USA 353 Antiretroviral Therapy in SIV Natural Hosts: Implications for AIDS Pathogenesis

357 Predicting Determinants of Long-TermHIV Control With Gene Therapy Strategies Alison L. Hill 1 ; Lily Hu 1 ; Louise Hogan 2 ; Martin A. Nowak 1 ;Timothy J. Henrich 2 1 HarvardUniv,Boston,MA,USA; 2 UnivofCaliforniaSanFrancisco,San Francisco,CA,USA 358LB T-Cell Homeostasis and CD8 Responses Predict Viral Control Post SB-728-T Treatment Joumana Zeidan 1 ; Gary K. Lee 2 ; Clarisse Benne 1 ; Slim Fourati 1 ; Shelley K.Wang 2 ; Jacob Lalezari 3 ; Gary Blick 4 ; Geoffrey M. Nichol 2 ; Dale K. Ando 2 ; Rafick Sekaly 1 1 CaseWesternReserveUniv,Cleveland,OH,USA; 2 SangamoBioSciences, Richmond,CA,USA; 3 QuestClinicalRsr,SanFrancisco,CA,USA; 4 CIRCLE CARECntr,LLC,Norwalk,CT,USA 2:45 PM-4:00 PM HIV Integration 359 Integration Analysis of Latently Infected Cell Lines: Evidence of Ongoing Replication Jori Symons 1 ; Abha Chopra 2 ; Eva Malantinkova 3 ;Ward Spiegelaerde 3 ; Shay Leary 2 ; Don Cooper 2 ; LinosVandekerckhove 3 ; Simon Mallal 2 ; Sharon R. Lewin 1 ; Paul U. Cameron 1 Session P-F6 Poster Abstracts Sara Sunshine 1 ; Rory Kirchner 2 ; Sami S. Amr 3 ; Michelle Kim 4 ; Alberto Bosque 5 ; Robert Siliciano 6 ;Vicente Planelles 5 ; Oliver Hofmann 2 ; Shannan Ho Sui 2 ; Jonathan Z. Li 1 1 BrighamandWomen’sHosp,HarvardMedSch,Boston,MA,USA; 2 HarvardSchofPH,Boston,MA,USA; 3 PartnersHlthCarePersonalized Med,Cambridge,MA,USA; 4 JohnsHopkinsUnivSchofMed,Baltimore, MD,USA; 5 UnivofUtah,SaltLakeCity,UT,USA; 6 HowardHughesMed Inst,Baltimore,MD,USA 361 Clonal Integration Site Frequency and Replication- Competent Virus in Patients on ART 1 GhentUnivandGhentUnivHosp,Ghent,Belgium; 2 Ragon InstofMGH, MITandHarvard,Cambridge,MA,USA; 3 SeattleChildren'sRsr Inst, Seattle,WA,USA 362 Measurement of Integrated HIV DNA by Pulse-Field Gel Electrophoresis and ddPCR Steven Lada ; Caroline Ignacio; Douglas D. Richman; Matt F. Strain UnivofCaliforniaSanDiego,SanDiego,CA,USA 363 Inhibition of the IN-LEDGF/p75 interplay by LEDGINs Reduces Reactivation From Latency Zeger Debyser 1 ; LenardVranckx 1 ; Jonas Demeulemeester 1 ; Annegret Boll 2 ; Rik Schrijvers 1 ; EricVerdin 3 ; Suha Saleh 1 ; Frauke Christ 1 ; Rik Gijsbers 1 1 KatholiekeUniversiteitLeuven,Leuven,Belgium; 2 UnivofTrento,Trento, Italy; 3 Gladstone InstofVirologyand Immunology,SanFrancisco,CA,USA Maja Kiselinova 1 ;Ward Spiegelaerde 1 ; Maria J. Buzon 2 ; Sherry McLaughlin 3 ; Mathias Lichterfeld 2 ; Lisa Frenkel 3 ; Linos Vandekerckhove 1 Hall A/B 1 Doherty Inst for Infectionand Immunity,UnivofMelbourne,Melbourne, Australia; 2 Inst for Immunology& InfectiousDiseases,MurdochUniv, Murdoch,Australia; 3 GhentUnivandGhentUnivHosp,Ghent,Belgium 360 HIV Integration Sites in Cellular Models of Viral Persistence

Poster Listings

83

CROI 2016