CROI 2016 Program at a Glance

Program and Agenda

Session P-C1 Poster Abstracts

Hall A/B

239 Cenicriviroc Decreases sCD14 and LBP Levels Without Affecting Gut Permeability Netanya S. Utay 1 ; Anoma Somasunderam 1 ; Maitreyee Nigalye 1 ;Will Chang 2 ; Star Seyedkazemi 2 ; Eric Lefebvre 2 1 UnivofTexasMedBranchatGalveston,Galveston,TX,USA; 2 Tobira Therapeutics, Inc,SanFrancisco,CA,USA 2:45 PM-4:00 PM HIV Effects on CD4+ T Cells 240 In Vivo Evidence for a Role of Pyroptosis in HIV Pathogenesis Gilad Doitsh ; Stefanie Sowinski; Caroline Miller;Warner C. Greene Gladstone Insts,SanFrancisco,CA,USA 241 Caspase Inhibition Prevents HIV Replication and Cell Death in Human Lymphoid Tissue Elisabet Gómez-Mora 1 ; Elisabet Garcia 1 ; PeterWienberg Ludwig 2 ; Maria Dolores Guerrero Gilabert 3 ; Bonaventura Clotet 4 ; Julià Blanco 5 ; Cecilia Cabrera 6 1 IrsiCaixa Inst forAIDSRsr,Badalona,Spain; 2 HospSant JoandeDéu, Barcelona,Spain; 3 HospUniversitariGermansTrias iPujol,Badalona, Spain; 4 LluitaContra laSIDAFndn,GermansTrias iPujolUnivHosp, Barcelona,Spain; 5 UnivdeVic,Barcelona,Spain; 6 IrsiCaixa Inst forAIDS Rsr,Barcelona,Spain 242 Follicular Regulatory T Cells Are Highly Permissive to HIV-1 Ex Vivo Shannon Miller ; Elizabeth Connick UnivofColorado,Denver,CO,USA 243 Dead Cells Tell No Tales: The Enigma of Discerning HIV- Infected Cell Death Nathan Cummins ; Sekar Natesampillai; Michele Smart; Scott H. Kaufmann; Andrew D. Badley MayoClinic,Rochester,MN,USA 244 Multidimensional Profiling of HIV-Infected Human CD4 T Memory Stem Cells Lara Manganaro 1 ; Jeffrey Johnson 2 ; Ekta Sharma; Patrick Hong; Benhur Lee 3 ; Nevan Krogan 2 ;Viviana A. Simon Session P-C2 Poster Abstracts

2:45 PM-4:00 PM HIV and Intestinal Integrity 233 Gut Integrity, CD4 T Follicular Helper Cells, and IgA+ B Cells in GALT Following ART John J. Zaunders 1 ; Gerald Mak 2 ; Michelle Bailey 2 ; Nabila Seddiki 3 ; Yin Xu 2 ; David Cooper 4 ; Mark Boyd 5 ; Anthony Kelleher 2 ; Mark Danta 6 ; Kersten K. Koelsch 5 1 StVincent'sHosp,Darlinghurst,Australia; 2 UnivofNewSouthWales, Sydney,Australia; 3 UniversiteParisEstCreteil,Creteil,France; 4 Kirby Inst,Sydney,Australia; 5 Kirby Inst,UnivofNewSouthWales,Sydney, Australia; 6 StVincent’sClinicalSch,UnivofNewSouthWales,Sydney, Australia 234 Microbial Translocation and Inflammation Responses to Lubiprostone in HIV Infection Gregory D. Huhn 1 ; Anna L. Hotton 2 ; Andrew G. Sigman 1 ; Sheila M. Keating 3 1 RuthM.RothsteinCORECntr,Chicago, IL,USA; 2 JohnH.Stroger JrHosp ofCookCounty,Chicago, IL,USA; 3 BloodSystemsRsr Inst,SanFrancisco, CA,USA 235 A20 May Contribute to Recovery of Intestinal Epithelial Function in Treated HIV Avantika Chitre ; Ma Somsouk; PeterW. Hunt; Charlie C. Kim; Joseph M. McCune UnivofCaliforniaSanFrancisco,SanFrancisco,CA,USA 236 Compartment-Specific Alterations of the Intestinal ILC Pool in HIV(+) Patients Benjamin Krämer 1 ; Philipp Lutz 1 ; Felix Goeser 1 ; Andreas Glässner 1 ; Jürgen K. Rockstroh 2 ; Christoph Boesecke 3 ; Ulrich Spengler 1 ; Jacob Nattermann 1 1 UnivofBonn,Bonn,Germany; 2 MedizinischeUnivsklinik,Bonn, Germany; 3 UnivHospBonn,Bonn,Germany 237 IL-33/ST2 Axis as an Inflammatory and Gut Damage Marker in Primary HIV Infection VikramMehraj 1 ; Mohammad-Ali Jenabian 2 ;Wei Cao 1 ; Rosalie Ponte 3 ; Bertrand Lebouché 4 ; RéjeanThomas 5 ; Jean-Guy Baril 6 ; Roger LeBlanc 7 ; CécileTremblay 8 ; Jean-Pierre Routy 1 1 Rsr Instof theMcGillUnivHlthCntr,Montreal,QC,Canada; 2 Univdu QuébecàMontréal,Montreal,QC,Canada; 3 Rsr Instof theMcGillUniv HlthCntr,Montréal,QC,Canada; 4 McGillUnivHlthCntr,Montreal,QC, Canada; 5 CliniqueMédicale l'Actuel,Montreal,QC,Canada; 6 Clinique MédicaleQuartierLatin,Montreal,QC,Canada; 7 CliniqueMédicaleOPUS, Montreal,QC,Canada; 8 CRCHUM,Montreal,QC,Canada 238 Probiotics Module Th1/Th17 and IFN Response in HIV Patients on Suppressive cART Ivan Schietroma 1 ; Noemi Giustini 1 ; Sara Serafino 1 ; Gabriella De Girolamo 1 ; Mauro Andreotti 2 ; Carolina Scagnolari 1 ; Giancarlo Ceccarelli 1 ; Gabriella D’Ettorre 1 ;VincenzoVullo 1 ; for the Carla Selvaggi, Giuseppe Corano, Andrea Mastrangelo, Gianfranco Fanello, Fausto Fiocca, Marileda Indinnimeo 1 SapienzaUnivofRome,Rome, Italy; 2 InstSuperiorediSanità,Rome, Italy

Hall A/B

Poster Listings

1 IcahnSchofMedatMountSinai,NewYork,NY,USA; 2 UnivofCalifornia SanFrancisco,SanFrancisco,CA,USA; 3 UnivofCaliforniaLosAngeles,Los Angeles,CA,USA

245LB Single Cell Transcriptome Sequencing of Human Lymph Node HIV-Infected CD4 Cells

Joseph P. Casazza 1 ; Eli Boritz 1 ; David Ambrozak 2 ; Amy R. Henry 1 ; Sam W. Darko 2 ; Costantinos Petrovas 2 ; Rebecca M. Lynch 1 ; Gustavo Reyes Teran 3 ; Daniel C. Douek 1 ; Richard A. Koup 1 1 VRC,NIAID,NIH,Bethesda,MD,USA; 2 NIH,Bethesda,MD,USA; 3 Natl Inst ofRespiratoryDiseases,MexicoCity,Mexico

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CROI 2016