CROI 2016 Program at a Glance

Program and Agenda

WEDNESDAY, FEBRUARY 24, 2016 Wednesday Plenary Sessions Auditorium 8:30 AM-9:30 AM 8:30 78 Progress in Gene Therapy for HIV Cure Paula M. Cannon ,UniversityofSouthern California,LosAngeles,CA,USA CME

11:00 84 Clones of SIV-Infected Cells Are Present in Spleen and Lymph Nodes in Rhesus Macaques Andrea Ferris 1 ; Gregory Q. Del Prete 2 ; Brandon Keele 2 ; Xiaolin Wu 2 ; Jeffrey Lifson 2 ; Stephen H. Hughes 1 1 NCI,Frederick,MD,USA; 2 FrederickNatlLab,Frederick,MD,USA 11:15 85 ART Reduces Cellular HIV RNA but Not the Fraction of Proviruses Transcribing RNA 1 UnivofPittsburgh,Pittsburgh,PA,USA; 2 HIVDynamicsand ReplicationProg,NatlCancer Inst,Frederick,MD,USA; 3 NCI, Frederick,MD,USA; 4 LeidosBiomedRsr, Inc,Frederick,MD,USA; 5 TuftsUniv,Boston,MA,USA 11:30 86 Restricted HIV-1 Diversity and Clonal Expansion Following Cytoreductive Chemotherapy 1 UnivofCaliforniaSanFrancisco,SanFrancisco,CA,USA; 2 MassachusettsGeneralHosp,Boston,MA,USA; 3 Ragon Inst ofMGH,MITandHarvard,Cambridge,MA,USA; 4 Brighamand Women’sHosp,HarvardMedSch,Boston,MA,USA; 5 Dana-Farber Cancer Inst,Boston,MA,USA; 6 HarvardMedSch,Boston,MA,USA 11:45 87 Virological Remission After ART Interruption in African HIV-1 Seroconverters Morgane Gossez 1 ; Gita Ramjee 2 ; Jacob Hurst 1 ; Pontiano Kaleebu 3 ; Helen Rees 4 ; Kholoud Porter 5 ; Abdel Babiker 6 ; Sarah J. Fidler 7 ; John Frater 1 ; for the SPARTACTrial Investigators Feiyu Hong 1 ; Jonathan Spindler 2 ; Andrew Musick 3 ; Anthony R. Cillo 1 ; Michael Bale 2 ;Wei Shao 4 ; John M. Coffin 5 ; JohnW. Mellors 1 ; Mary F. Kearney 3 Timothy J. Henrich 1 ; Eileen P. Scully 2 ; Kristen S. Hobbs 1 ; Emily Hanhauser 1 ; Louise Hogan 1 ; Christine D. Palmer 3 ;Yvonne P. Robles 4 ; Kaitlyn S. Leadabrand 1 ; Ann S. LaCasce 5 ; Daniel Kuritzkes 6

9:00 79 HIV in Transgender Populations: Charted and UnchartedWaters Tonia C. Poteat ,The JohnsHopkins University,Baltimore,MD,USA

Session O-6 Oral Abstracts

Ballroom B/C

10:00 AM-12:00 PM Reservoirs, Relapse, and Remission Oral Abstract Moderators

Carolina Gutiérrez ,RamónyCajalHospital, IRYCIS,Madrid,Spain Jonathan Z. Li ,BrighamandWomen'sHospital,HarvardMedicalSchool, Boston,MA,USA 10:00 80 Investigating the Mechanisms that Control HIV Transcription and Latency In Vivo Steven A.Yukl 1 ; Philipp Kaiser 1 ; Peggy Kim 1 ; Sunil K. Joshi 1 ; Nicholas Kim 1 ; Peilin Li 1 ; Harry Lampiris 1 ; Hongbing Liu 2 ; Andrew Rice 2 ; Joseph K.Wong 1 ; for the DARE Study Group 1 SanFranciscoVAMedCntr,SanFrancisco,CA,USA; 2 BaylorCollof Med,Houston,TX,USA 10:15 81 Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation Mohamed Abdel-Mohsen 1 ; Leonard Chavez 1 ; Glen M. Chew 2 ; Xutao Deng 1 ; Ali Danesh 1 ; Sheila M. Keating 1 ; Rebecca Hoh 3 ; Steven G. Deeks 3 ; Lishomwa C. Ndhlovu 2 ; Satish Pillai 1 1 BloodSystemsRsr Inst,SanFrancisco,CA,USA; 2 UnivofHawaii, Honolulu,HI,USA; 3 UnivofCaliforniaSanFrancisco,San Francisco,CA,USA 10:30 82 PD-1+ and Tfh Cells Represent the Major Source of HIV-1 Replication-Competent Virus Riddhima Banga 1 ; Francesco Procopio 1 ; Matthias Cavassini 2 ; Jean-Marc Corpataux 3 ; Giuseppe Pantaleo 3 ; Matthieu Perreau 1 1 CHUV,Epalinges,Switzerland; 2 UnivHospLausanne,Univof Lausanne,Lausanne,Switzerland; 3 CHUVaudois,Lausanne, Switzerland 10:45 83 Rapid Accumulation of Defective Proviruses

1 UnivofOxford,Oxford,UK; 2 SouthAfricanMedRsrCouncil,Cape Town,SouthAfrica; 3 MedRsrCouncil/UgandaVirusRsr Inst UgandaRsrUnitonAIDS,Entebbe,Uganda; 4 WitsReproductive HlthandHIV Inst, Johannesburg,SouthAfrica; 5 MedRsrCouncil, London,UK; 6 UnivCollLondon,London,UK; 7 ImperialCollLondon, London,UK

Oral Sessions • Wednesday, February 24, 2016

Session O-7 Oral Abstracts

Room 304/306

10:00 AM-12:00 PM Pushing Frontiers of Adaptive Immunity Oral Abstract Moderators

Gregory Q. Del Prete ,FrederickNationalLaboratory,Frederick,MD,USA Peter D. Kwong ,VaccineResearchCenter,NIAID/NIH,Bethesda,MD,USA 10:00 88 An Infant bNAbWith Low Somatic Hypermutation Contributes to Polyclonal Breadth Cassandra Simonich 1 ; KatherineWilliams 1 ;Theodore Gobillot 2 ; Hadega Aamer 3 ; Stephanie Rainwater 1 ; Ruth Nduati 4 ; Julie M. Overbaugh 1 1 FredHutchinsonCancerRsrCntr,Seattle,WA,USA; 2 Univof Washington,Seattle,WA,USA; 3 SeattleChildren’sRsr Inst,Seattle, WA,USA ; 4 UnivofNairobi,Nairobi,Kenya

Complicates HIV-1 Reservoir Measurements Katherine M. Bruner 1 ; Ross Pollack 1 ; Alexandra Murray 1 ; Mary Soliman 1 ; Sarah B. Laskey 2 ; Matt F. Strain 3 ; Douglas D. Richman 3 ; Steven G. Deeks 4 ; Janet Siliciano 1 ; Robert Siliciano 5 1 JohnsHopkinsUnivSchofMed,Baltimore,MD,USA; 2 Johns HopkinsUniv,Baltimore,MD,USA; 3 UnivofCaliforniaSanDiego, SanDiego,CA,USA; 4 UniversityofCaliforniaSanFrancisco,San Francisco,CA,USA; 5 HowardHughesMed Inst,Baltimore,MD,USA

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CROI 2016