CROI 2016 Program at a Glance

Program and Agenda

Room 304/306

11:00 37 Similar Mortality With Cotrimoxazole vs Placebo in HIV-Exposed Uninfected Children

Session O-3 Oral Abstracts

10:00 AM-12:00 PM Prevention and Treatment of Pediatric HIV Infections Oral Abstract Moderators Jason Brophy, Children'sHospitalofEasternOntario,Ottawa,ON,Canada Karin Nielsen-Saines, UniversityofCaliforniaLosAngeles,LosAngeles,CA, USA 10:00 33 Breast Milk and In Utero HIV-1 Transmission Select for Unique Envelope Signatures

Roger L. Shapiro 1 ; Michael Hughes 1 ; Kathleen Powis 2 ; Gbolahan Ajibola 3 ; Kara Bennett 4 ; Sikhulile Moyo 3 ; Joseph Makhema 3 ; Sheryl Zwerski 5 ; M. Essex 1 ; Shahin Lockman 6 1 HarvardSchofPH,Boston,MA,USA; 2 MassachusettsGeneral Hosp,Boston,MA,USA; 3 BotswanaHarvardAIDS InstPartnership, Gaborone,Botswana; 4 BennettStatisticalConsulting, Inc., BallstonLake,NY,USA; 5 NIH,Bethesda,MD,USA; 6 Brighamand Women’sHosp,HarvardMedSch,Boston,MA,USA

11:15 38 Urgent Versus Post-Stabilization ART in Hospitalized Children: A Randomized Trial Irene N. Njuguna 1 ; Lisa M. Cranmer 2 ;Vincent O. Otieno 1 ; Helen M. Okinyi 1 ; Sarah Benki-Nugent 3 ; Joshua Stern 3 ; Ken Tapia 3 ; Elizabeth Maleche-Obimbo 1 ; DaltonWamalwa 1 ; Grace C. John-Stewart 3 1 UnivofNairobi,Nairobi,Kenya; 2 EmoryUnivSchofMed,Atlanta, GA,USA; 3 UnivofWashington,Seattle,WA,USA 11:30 39 Three-Year Outcomes in PMTCT-Exposed Children Switched to EFV Once Suppressed on LPVr 1 ColumbiaUniv, Johannesburg,SouthAfrica; 2 Univof the Witwatersrand, Johannesburg,SouthAfrica; 3 ColumbiaUniv MedCntr,NewYork,NY,USA; 4 ColumbiaUniv,NewYork,NY,USA; 5 ICAP,ColumbiaUnivMailmanSchofPH,NewYork,NY,USA 11:45 40 Efavirenz Is AssociatedWith Higher Bone Mass in South African ChildrenWith HIV Pamela Murnane 1 ; Renate Strehlau 2 ; Stephanie Shiau 3 ; Sarah Ramteke 4 ; Faeezah Patel 2 ; Elaine J. Abrams 5 ; Ashraf Coovadia 2 ; Louise Kuhn 4 ; for the NEVEREST III StudyTeam

Thomas A.Wilkinson 1 ; Kyle J. Nakamura 1 ; Laura M. Heath 2 ; Katherine Semrau 3 ; Chipepo Kankasa 4 ; Nicholas E.Webb 5 ; Benhur Lee 5 ; Louise Kuhn 6 ; James I. Mullins 2 ; Grace M. Aldrovandi 1 1 Children'sHospofLosAngeles,LosAngeles,CA,USA; 2 Univof Washington,Seattle,WA,USA; 3 BostonUnivSchofPH,Boston, MA,USA; 4 UnivTeachingHosp,Lusaka,Zambia; 5 Univof CaliforniaLosAngeles,LosAngeles,CA,USA; 6 ColumbiaUniv,New York,NY,USA Retention in Swaziland: A Stepped-Wedge Trial Elaine J. Abrams 1 ; Nontokozo Langwenya 2 ; Averie Gachuhi 3 ; Allison Zerbe 3 ;Thabo Hlophe 4 ; Simangele Mthethwa-Hleta 5 ; Harriet Nuwagaba-Biribonwoha 4 ; Ruben Sahabo 4 ;Velephi Okello 5 ; Landon Myer 2

10:15 34 Impact of Option B+ on ART Uptake and

1 ICAP,ColumbiaUnivMailmanSchofPH,NewYork,NY,USA; 2 UnivofCapeTown,CapeTown,SouthAfrica; 3 ICAPatColumbia Univ,NewYork,NY,USA; 4 ICAPatColumbiaUniv,Mbabane, Swaziland; 5 MinistryofHlth,Mbabane,Swaziland 10:30 35LB National HIV Transmission in 4-12Week Olds in Malawi’s PMTCT Option B+ Program

Oral Sessions • Tuesday, February 23, 2016

Stephen M. Arpadi 1 ; Stephanie Shiau 1 ; Renate Strehlau 2 ; Faeezah Patel 2 ; Louise Kuhn 3 ; Ashraf Coovadia 2 ; Don McMahon 1 ; Jonathan J. Kaufman 4 ; MichaelT.Yin 1 ; for the CHANGES Bone StudyTeam 1 ColumbiaUnivMedCntr,NewYork,NY,USA; 2 Univof the Witwatersrand, Johannesburg,SouthAfrica; 3 ColumbiaUniv,New York,NY,USA; 4 MountSinaiSchofMed,NewYork,NY,USA

BethTippett Barr 1 ; Erik Schouten 2 ; Joep van Oosterhout 3 ; Sundeep K. Gupta 4 ; Happy Phiri 2 ; DeusThindwa 2 ; Christopher Blair 2 ; Andreas Jahn 5 ; Monique von Lettow 6 ; for the NEMAPP Consortium

1 CDC,Harare,Zimbabwe; 2 ManagementSciences forHlth, Lilongwe,Malawi; 3 Dignitas Intl,Zomba,Malawi; 4 CDC, Lilongwe,Malawi; 5 MinistryofHlth,Lilongwe,Malawi; 6 Dignitas International,Lilongwe,Malawi 10:45 36 Impact of Maternal Tenofovir Use on HIV-Exposed Newborn Bone Mineral

Session O-4 Oral Abstracts

Auditorium

10:00 AM-12:00 PM Complications fromHead to Toe Oral Abstract Moderators Kristine M. Erlandson, UniversityofColorado,Denver,CO,US Chris T. Longenecker, CaseWesternReserveUniversity,Cleveland,OH,US

George K. Siberry 1 ; CamlinTierney 2 ; Lynda Stranix-Chibanda 3 ; Caroline Marr 2 ; John A. Shepherd 4 ; Renee Browning 5 ; Heidi J. Kalkwarf 6 ; Kathleen George 7 ; Mary G. Fowler 8 ; for the IMPAACT P1084s StudyTeam 1 EuniceKennedyShriverNICHD,Bethesda,MD,USA; 2 HarvardSch ofPH,Boston,MA,USA; 3 UnivofZimbabwe,Harare,Zimbabwe; 4 UnivofCaliforniaSanFrancisco,SanFrancisco,CA,USA; 5 NIAID, NIH,Rockville,MD,USA; 6 CincinnatiChildren'sHospMedCntr, Cincinnati,OH,USA; 7 IMPAACTOperations,Durham,NC,USA; 8 JohnsHopkinsUnivSchofMed,Baltimore,MD,USA

10:00 41 Early Antiretroviral Therapy Does Not Improve Vascular Function: A START Substudy

JasonV. Baker 1 ; Katherine Huppler Hullsiek 2 ; NicoleWyman Engen 2 ; Daniel Duprez 2 ; for the INSIGHT START (StrategicTiming of AntiRetroviralTreatment) Arterial Elasticity SubstudyTeam 1 HennepinCountyMedCntr,UnivofMinnesota,Minneapolis,MN, USA; 2 UnivofMinnesota,Minneapolis,MN,USA

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CROI 2016