CROI 2016 Abstract eBook

Abstract Listing

Poster Abstracts

Children with LA were more likely to resolve if older at diagnosis of LA (adjusted odds ratio [aOR] 1.51/additional year of age [95%CI 1.01, 2.26], p=0.05) or had greater duration of exposure to LPV prior to diagnosis of LA (aOR 1.65/additional year of exposure [95%CI 1.00, 2.74], p=0.05), and less likely to resolve if they were girls (aOR 0.06 [95%CI 0.00, 0.87], p=0.04). No factors were associated with increased likelihood of resolution of LH. Conclusions: Established LA and LH in children are largely persistent, requiring on-going follow-up to mitigate stigmatizing psychosocial effects and any other morbidity.

856 Patterns of Systemic Hypertension Among Adults With Perinatally Acquired HIV Patrick A. Ryscavage ;Thomas Macharia; Lino R.Trinidad; Susan Lovelace;VickiTepper; Robert R. Redfield Univ of Maryland Sch of Med, Baltimore, MD, USA Background: Patients with perinatally acquired HIV may be at risk for the development of age-related non-AIDS diseases. The primary aim of this study was to describe patterns of systemic hypertension among a cohort of adults (≥18 years) with perinatally-acquired HIV. Methods: This retrospective study was conducted among patients with perinatally-acquired HIV infection who received care in the University of Maryland Medical System. Participants were included if they had reached at least 18 years of age as of September 30, 2013. The objectives were to characterize the incidence, prevalence, and patterns of systemic hypertension. Incidence rates of systemic hypertension were calculated and rate ratios were generated based upon age at hypertension diagnosis within one of two age groups, ≥18 and <18 years. Systemic hypertension was defined as one or both of the following: 1) Provider documentation of systemic hypertension diagnosis, 2) Receipt of antihypertensive medications for blood pressure management. Descriptive statistics, including mean, median, standard deviation and quartiles for continuous measures were used to characterize the study population. Multivariable logistic regression was used to evaluate independent predictors of hypertension. Results: The mean age of the overall cohort (N=109) was 22.8 years (range 18.5-30.2 years). The majority (93%) was African American, and 55%were female. The overall prevalence of hypertension in the cohort was 26.6%, and the incidence rate of hypertension was significantly higher among those aged ≥18 years (4.59 per 100 person-years) compared to those who had reached ages <18 years (0.46 per 100 person-years) at time of diagnosis (RR 10.0, CI 7.29-13.71). By multivariable analysis, only coexisting renal disease was associated with an increased risk of hypertension diagnosis (OR 4.93, 95% CI 1.79-13.62), though this association appeared to be strongest among those with a hypertension diagnosis at <18 years. Conclusions: The prevalence of systemic hypertension among adults with perinatally-acquired HIV in this cohort greatly exceeded normative values for the general population (0.3% at 25 years) and incidence rates appeared to increase during early adulthood (≥18 years). Coexisting renal disease may be a risk factor for systemic hypertension though this relationship may not be as strong in adulthood. Adult providers may need to closely monitor for the development of hypertension in perinatally-infected patients as they age into adulthood.

Poster Abstracts

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Prevalence of Persistent Renal Dysfunction in Perinatal Thai HIV Adolescents Tanit Phupitakphol 1 ;Torsak Bunupuradah 1 ; Jiratchaya Sophonphan 1 ;Wasana Prasitsuebsai 1 ; Suvaporn Anugulruengkitt 2 ;Watsamon Jantarabenjakul 2 ; Bunruan Sopa 1 ; Kiat Ruxrungtham 1 ; Ankanee Chanakul 2 ;Thanyawee Puthanakit 2 ; for the HIV-NAT015 cohort 1 HIV-NAT, Thai Red Cross AIDS Rsr Cntr, Bangkok, Thailand; 2 Chulalongkorn Univ, Bangkok, Thailand Background: With access to antiretroviral therapy (ART), perinatally HIV-infected children can live longer but chronic diseases including renal complications play more roles. There are limited data of persistent renal dysfunction (PRD) in this population. Here, we report prevalence and incidence of PRD and associated factors. Methods: Data of perinatally HIV-infected Thai adolescents from a pediatric HIV cohort with their current aged >10 years old and had documented serum creatinine (Cr) >2 times after ART initiation were included for analysis. Children with history of renal diseases before ART initiation were excluded. Cr and urine examination were performed every 6

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