CROI 2016 Abstract eBook

Abstract Listing

Poster Abstracts

impairment; 6% had ≥2 IADL impairments. The most common impairments involved housekeeping (48%), transportation (36%), shopping (28%), laundry (20%), and cooking (15%). Of the 999 who also had frailty assessed, frail participants were more likely to report IADL impairment (52% had ≥1 impairment vs. 21% of pre- and 11% of non-frail). In univariate models, no significant associations were seen between IADL impairment and nadir/current CD4, HIV-1 RNA, initial ART regimen, prior exposure to ZDV, D4T, or DDI; years since ART initiation; substance use; obesity or weight change since ART initiation; renal disease; hypertension; or cancer. Neuroimpairment, public insurance (vs private/ other), education, and low physical activity were associated with impairment in the final model (Table). Conclusions: In HIV+ older adults, IADL impairment occurs more frequently among those with neuroimpairment or frailty. Modifiable risk factors (smoking, low physical activity) provide targets for interventions to help maintain independent living.

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Fitness Characteristics of United States Air Force Members With HIV Infection Asha R. De 1 ; Xiahoe Xu 2 ; JamesWhite 2 ;Thankam Sunil 2 ; Jason Okulicz 3 1 San Antonio Military Med Cntr, Fort Sam Houston, TX, USA; 2 Univ of Texas San Antonio, San Antonio, TX, USA; 3 San Antonio Military Med Cntr, San Antonio, TX, USA Background: HIV infection has been associated with early cardiovascular disease, reduced muscle mass, and adverse metabolic effects. To better understand the impact of HIV on physical fitness, we evaluated longitudinal fitness characteristics for active duty United States Air Force (USAF) members with and without HIV infection. Methods: Since 2004, USAF members perform a standardized fitness test every 6-12 months with a composite score (CS) comprised of abdominal circumference (AC), push-ups (PU), sit-ups (SU), and 1.5-mile run. Scores in each area are based on decade of age, gender, and amount of repetitions or elapsed time. A CS ≥75 is required to pass and ≥90 is defined as excellent. Male USAF members with HIV infection (n=172) and fitness tests between 2004-2014 were compared with male HIV-negative controls (~10 per case; n=1,636) matched by age at military service entry and rank category. Body mass index (BMI) was also analyzed. Fitness tests for cases were divided into two groups for comparison by paired t-tests: before HIV diagnosis (pre-HIV) and after HIV diagnosis (post-HIV). Fitness tests for cases in each category were also compared to tests for controls of the same age. Random effects regression analyses were also performed to compare characteristics for cases and controls. Results: The majority of cases were enlisted members (91.3%) with mean age of 21.3 (±3.5) and 28.1 (±6.4) years at military service entry and HIV diagnosis, respectively. Cases had lower AC and BMI both Pre- and Post-HIV compared to controls (Table). Pre-HIV tests showed similar CS but lower scores for muscle strength components (SU and PU) compared to controls. Similar results were observed Post-HIV versus controls, however Post-HIV CS was significantly greater. Among cases, Post-HIV values of CS, SU, and PU were significantly greater compared to Pre-HIV values. Panel regression analyses controlling for background characteristics showed that cases had lower BMI, AC and PU scores regardless of Pre- or Post-HIV status, however the odds of an excellent CS were 75.1% higher for Post-HIV cases than for controls. Conclusions: USAF members with HIV exhibit a high level of physical fitness with greater overall CS and excellent scores than HIV-uninfected controls. Although muscle strength scores were lower compared to controls, these components improved Post-HIV. These results suggest that USAF members can effectively maintain muscle mass and cardiovascular performance after HIV diagnosis.

Poster Abstracts

723 Frailty in HIV-Infected Patients Is AssociatedWith Increased insulin Resistance Dominic Chow ; Lindsay M. Kohorn;Tanawan Riangwiwat; Scott C. Souza; Kalpana J. Kallianpur; Beau K. Nakamoto; Lishomwa C. Ndhlovu; Cecilia M. Shikuma Univ of Hawaii, Honolulu, HI, USA Background: Physical frailty develops earlier in HIV-infected than in uninfected individuals. In the general population, frailty is associated with insulin resistance. Methods: We examine the association between frailty and indices of glucose metabolism in HIV-infected patients on stable antiretroviral therapy (ART). This subgroup analysis utilized baseline data from the Hawaii Aging with HIV-Cardiovascular Study. Frailty was defined as a syndrome meeting 3 or more of 5 phenotypic criteria: weakness, assessed by grip strength; slowness, assessed by the 15 feet walking time; low physical activity; low energy or self-reported exhaustion; and unintentional weight loss. Patients with 1 or 2 criteria were considered Pre-Frail and those with 0 phenotypic traits were considered Non-Frail. Insulin resistance was assessed by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and the Oral Disposition Index (DIo), a dynamic measure of insulin resistance using a 2 hour oral glucose tolerance test (OGTT). Biomarkers (sE-selectin,

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CROI 2016