CROI 2015 Program and Abstracts

Oral Sessions

Session TD-O Themed Discussion

Room 6D

835 Antiretroviral Therapy Alters the CSF Immune Response in Cryptococcal Meningitis James E. Scriven 1 ; Britta Urban 1 ; Lisa Graham 2 ; Charlotte Schutz 2 ; Robert J.Wilkinson 3 ; David R. Boulware 4 ; David Lalloo 1 ; Graeme Meintjes 2 1 Liverpool School of Tropical Medicine, Liverpool, United Kingdom; 2 University of Cape Town, Cape Town, South Africa; 3 Imperial College London, London, United Kingdom; 4 University of Minnesota, Minneapolis, MN, US 836 Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation Joshua Rhein 1 ; Katherine H. Hullsiek 1 ; Nathan C. Bahr 1 ; Reuben Kiggundu 3 ; Darlisha Williams 3 ; HenryW. Nabeta 3 ; Abdu Musubire 3 ; David B. Meya 3 ; David R. Boulware 1 1 University of Minnesota, Minneapolis, MN, US; 2 University of Minnesota, Minneapolis, MN, US; 3 Makerere University College of Health Sciences, Kampala, Uganda 837 Impact of ART on Mortality in Cryptococcal Meningitis Patients: High- Income Settings Suzanne M. Ingle 1 ; Jose M. Miro 2 ; Hansjakob Furrer 4 ; Amy Justice 5 ; Michael S. Saag 6 ; Christian Manzardo 2 ; Anna Esteve 7 ; Lauren E. Cain 3 ; Jonathan A. Sterne 1 ; MargaretT. May 1 1 University of Bristol, Bristol, United Kingdom; 2 Hospital Clínic–L’Institut D’Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain; 3 Harvard School of Public Health, Boston, MA, US; 4 Bern University Hospital and University of Bern, Bern, Switzerland; 5 Yale University School of Medicine, VA Connecticut Healthcare System, New Haven, CT, US; 6 University of Alabama at Birmingham, Birmingham, AL, US; 7 Centre d’Estudis Epidemiològics Sobre ITS/VIH/SIDA de Catalunya, Barcelona, Spain 838 Adjunctive Sertraline for the Treatment of HIV-Associated Cryptococcal Meningitis Joshua Rhein 1 ; Katherine H. Hullsiek 1 ; Bozena Morawski 1 ; Kyle Smith 1 ; Ali Al-Hadab 1 ; Abdu Musubire 2 ; DarlishaWilliams 2 ; Kristen Nielsen 1 ; David B. Meya 2 ; David R. Boulware 1 1 University of Minnesota, Minneapolis, MN, US; 2 Makerere University College of Health Sciences, Kampala, Uganda Session TD-W Themed Discussion Room 6AB 1:30 pm– 2:30 pm Serosorting and Seroadaptive Behavior: What’s Your Position? Themed Discussion Leader Andrew E. Grulich , University of New South Wales, Sydney, NSW, Australia 1060 Trends in Sexual Behaviors Among MenWho Have Sex With Men in the United States, the Role of Antiretroviral Therapy and Seroadaptive Strategies Gabriela Paz-Bailey 1 ; Maria Mendoza 1 ; Binh Le 1 ; Charles E. Rose 1 ;Teresa Finlayson 1 ; CyprianWejnert 1 ; Henry F. Raymond 2 ; Joseph Prejean 1 1 US Centers for Disease Control and Prevention (CDC), Atlanta, GA, US; 2 San Francisco Department of Public Health, San Francisco, CA, US 1061 Changes in Condomless Sex and Serosorting Among MSM After HIV Diagnosis Christine M. Khosropour 2 ; Julia C. Dombrowski 2 ; David A. Katz 2 ; Matthew R. Golden 2 1 University of Washington, Seattle, WA, US; 2 University of Washington, Seattle, WA, US 1062 Serosorting and Sexual Risk Behavior Influenced by Perceived HIV Serostatus Among MSM Kathleen A. Brady ; Jennifer Shinefeld; Catherine Mezzacappa Philadelphia Department of Public Health, Philadelphia, PA, US 1063 Use of the Seroadaptive Strategies of Sexual Positioning and Serosorting by MSM in Nigeria Cristina M. Rodriguez-Hart 1 ; Hongjie Liu 2 ; Ifeanyi K. Orazulike 3 ; Sam Zorowitz 4 ; Sylvia Adebajo 5 ; Lindsay Hughes 6 ; Stefan Baral 7 ; Merlin L. Robb 6 ;William Blattner 1 ; Manhattan Charurat 1 1 University of Maryland School of Medicine, Baltimore, MD, US; 2 University of Maryland School of Public Health, College Park, MD, US; 3 International Center on Advocacy and Rights to Health, Abuja, Nigeria; 4 Massachusetts General Hospital and Harvard Medical School, Boston, MA, US; 5 Population Council, Abuja, Nigeria; 6 US Military HIV Research Program, Bethesda, MD, US; 7 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US

1:30 pm– 2:30 pm Cancers in Young and Old, and Lung Cancer in HIV Themed Discussion Leader Eric A. Engels , National Cancer Institute (NCI), Bethesda, MD, US 724 Cancer in HIV-Infected Children: Record Linkage Study in South Africa Julia Bohlius 6 ; Nicky Maxwell 2 ; Brian Eley 3 ; Hans Prozesky 4 ; Shobna Sawry 1 ; Karl-Günter Technau 1 ; Alan Davidson 2 ; Cristina Stefan 5 ; Matthias Egger 6 On behalf of IeDEA Southern Africa 1 University of the Witwatersrand, Johannesburg, South Africa; 2 University of Cape Town, Cape Town, South Africa; 3 Red Cross War Memorial Children’s Hospital, Cape Town, South Africa; 4 University of Stellenbosch and Tygerberg Academic Hospital, Cape Town, South Africa; 5 Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa; 6 University of Bern, Bern, Switzerland 725 High Cancer Risk Among the HIV-Infected Elderly in the United States Elizabeth L. Yanik ; Hormuzd A. Katki; Eric A. Engels National Cancer Institute (NCI), Rockville, MD, US 726 Smoking Outweighs HIV-Related Risk Factors for Non–AIDS-Defining Cancers Keri N. Althoff 1 ; Stephen J. Gange 1 ; Chad Achenbach 2 ; Lisa P. Jacobson 1 ; Angel M. Mayor 3 ; Michael J. Silverberg 4 ; Amy Justice 5 ; Richard Moore 6 ;Yuezhou Jing 1 ; Kelly Gebo 6 On behalf of the North American AIDS Cohort Collaboration on Research and Design 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 2 Northwestern University, Feinberg School of Medicine, Chicago, IL, US; 3 Universidad Central del Caribe, Bayamon, US; 4 Kaiser Permanente Northern California, Oakland, CA, US; 5 Veterans Affairs Connecticut Healthcare System and Yale Schools of Medicine and Public Health, New Haven, CT, US; 6 Johns Hopkins University School of Medicine, Baltimore, MD, US 727 High Frequency of Early Lung Cancer Diagnosis With Chest CT in HIV- Infected Smokers Alain Makinson 1 ; Sabrina Eymard-Duvernay 2 ; François Raffi 3 ; Fabrice Bonnet 4 ; Laurence Thirard 5 ; PierreTattevin 6 ; Sophie Abgrall 7 ; Jacques Reynes 1 ;Vincent Le Moing 1 on behalf of the ANRS EP48 HIV CHEST StudyTeam 1 University Hospital Montpellier, UMI233, Montpellier, France; 2 UMI 233, IRD, University Montpellier 1, Montpellier, France; 3 Nantes University Hospital, Nantes, France; 4 University Hospital Bordeaux, Inserm U897, Bordeaux, France; 5 Tourcoing University Hospital, Tourcoing, France; 6 Pontchaillou University Hospital, Rennes, France; 7 University Hospital Avicennes, Bobigny, France; 8 ANRS, Paris, France 728 CD4 Measures as Predictors of Lung Cancer Risk and Prognosis in HIV Infection Keith Sigel 1 ; Kristina Crothers 2 ; Kirsha Gordon 3 ; Sheldon Brown 4 ; David Rimland 5 ; Maria Rodriguez-Barradas 6 ; Cynthia Gibert 7 ; Matthew B. Goetz 8 ; Roger Bedimo 9 ; Robert Dubrow 10 1 Icahn School of Medicine at Mount Sinai, New York, NY, US; 2 University of Washington School of Medicine, Seattle, WA, US; 3 VA Connecticut Healthcare System and Yale University Schools of Medicine and Public Health, New Haven, CT, US; 4 James J. Peters VA Medical Center, Bronx, NY, US; 5 Atlanta VA Medical Center, Atlanta, GA, US; 6 Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, US; 7 Washington DC Veterans Affairs Medical Center, Washington, DC, US; 8 Los Angeles VA Medical Center, Los Angeles, CA, US; 9 Veterans Affairs North Texas Health Care System, Dallas, TX, US; 10 Yale University School of Public Health, New Haven, CT, US 1:30 pm– 2:30 pm Cryptococcal Meningitis: Host Response, Treatment, and Outcomes Themed Discussion Leader Judith A. Aberg , Icahn School of Medicine at Mount Sinai, New York, NY, US 834 Local and Systemic Humoral Responses to Cryptococcal Meningitis in Patients With AIDS Erin E. Finn 1 ; Jordan Janoff 1 ; Jeremy Rahkola 1 ; David B. Meya 2 ; Samuel Okurut 2 ; Andrew D. Kambugu 2 ; Paul Bohjanen 3 ; Kirsten Nielsen 3 ; David R. Boulware 3 ; Edward N. Janoff 1 1 Mucosal and Vaccine Research Colorado, Aurora, CO, US; 2 Makerere University College of Health Sciences, Kampala, Uganda; 3 University of Minnesota, Minneapolis, MN, US Session TD-R Themed Discussion

Wednesday, February 25, 2015 • Oral Sessions

Room 6E

13

CROI 2015