CROI 2015 Program and Abstracts

Oral Sessions

107 Low-Level HIV Viremias Originate in Part From Infected Proliferating Cells Marta E. Bull 1 ; Sherry McLaughlin 2 ; Hannah Huang 2 ; Sheila Styrchak 2 ; Jaime Soria 3 ; EduardoTicona 3 ; Alberto La Rosa 4 ; Caroline Mitchell 5 ; James Mullins 1 ; Lisa Frenkel 1 1 University of Washington, Seattle, WA, US; 2 Seattle Children’s Research Institute, Seattle, WA, US; 3 Hospital Nacional dos de Mayo, Lima, Peru; 4 Investigaciones Médicas en Salud (INMENSA), Lima, Peru; 5 Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, US; 6 University of Washington, Seattle, WA, US 108 Treatment With a TLR7 Agonist Induces Transient Viremia in SIV-Infected ART-Suppressed Monkeys James B. Whitney 1 ; So-Yon Lim 1 ; Christa E. Osuna 1 ; Srisowmya Sanisetty 1 ;Tiffany L. Barnes 2 ; PeterT. Hraber 3 ;Tomas Cihlar 2 ; Romas Geleziunas 2 ; Joseph Hesselgesser 2 1 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US; 2 Gilead Sciences, Inc., Foster City, CA, US; 3 Los Alamos National Laboratories, Los Alamos, NM, US 109 Panobinostat Broadly Activates Latent HIV-1 Proviruses in Patients Kirston M. Barton 1 ;Thomas A. Rasmussen 2 ; MartinTolstrup 2 ;Wei Shao 4 ; Bonnie Hiener 1 ; Ajantha Solomon 3 ; Lars Østergaard 2 ; Sharon R. Lewin 3 ; Ole Søgaard 2 ; Sarah E. Palmer 1 1 Westmead Millennium Institute and University of Sydney, Westmead, Australia; 2 Aarhus University Hospital, Aarhus, Denmark; 3 Doherty Institute for Infection and Immunity, Melbourne, Australia; 4 National Cancer Institute, Rockville, MD, US 110LB The Size of the Active HIV Reservoir Predicts Timing of Viral Rebound Behzad Etemad 1 ; Hayat Ahmed 1 ; Evgenia Aga 2 ; Ronald Bosch 2 ; JohnW. Mellors 3 ; Daniel Kuritzkes 1 ; Michael Para 4 ; RajeshT. Gandhi 5 ; Jonathan Li 1 1 Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, US; 2 Harvard School of Public Health, Center for Biostatistics in AIDS Research, Boston, MA, US; 3 University of Pittsburgh, Pittsburgh, PA, US; 4 Ohio State University, Columbus, OH, US; 5 Massachusetts General Hospital, Harvard Medical School, Boston, MA, US 111LB Biomarkers to Predict Viral Rebound at Antiretroviral Therapy Interruption in SPARTAC Jacob Hurst 1 ; JamesWilliams 1 ; John P.Thornhill 2 ; Matthew Pace 1 ; ChrisWillberg 1 ; Elizabeth Hamlyn 3 ; Abdel Babiker 4 ; Rodney Phillips 1 ; Sarah Fidler 2 ; John Frater 1 on behalf of the SPARTACTrial Investigators 1 University of Oxford, Oxford, United Kingdom; 2 St Mary’s Hospital–Imperial College Healthcare NHS Trust, London, United Kingdom; 3 King’s College London, London, United Kingdom; 4 Medical Research Council Clinical Trials Unit, London, United Kingdom 112LB HIV-1 Diversity and Tropism of Rebound Virus After Treatment Discontinuation Maria M. Bednar 1 ; Blake Hauser 1 ; Jeffrey M. Jacobson 2 ; Ian Frank 4 ; Joseph J. Eron 3 ; Ronald Swanstrom 1 On behalf of the NWCS 379 team 1:30 pm– 2:30 pm Interferon: Triggers and Effectors Themed Discussion Leader Martin R. Jakobsen , Aarhus University,Aarhus C, Denmark 188 HIV-1 Exploits CD169 to Evade IFN α -Induced Antiviral State in Myeloid Cells Hisashi Akiyama 1 ; Nora Ramirez 1 ; Gregory Gibson 2 ; SimonWatkins 2 ; Zandrea Ambrose 2 ; Rahm Gummuluru 1 1 Boston University School of Medicine, Boston, MA, US; 2 University of Pittsburgh School of Medicine, Pittsburgh, PA, US; 3 University of Pittsburgh School of Medicine, Pittsburgh, PA, US 192 HIV and SIV Inhibition by RNA-Associated Early Stage Antiviral Factor (REAF) Aine McKnight Queen Mary University of London, London, United Kingdom 184 Regulation of the Innate Immune Sensing of HIV by the Viral Capsid and the Cytosolic DNA Sensor cGAS Nicolas Manel Institut Curie, Paris, France 1 University of North Carolina, Durham, NC, US; 2 Drexel University College of Medicine, Philadelphia, PA, US; 3 University of North Carolina, Chapel Hill, NC, US; 4 University of Pennsylvania, Philadelphia, PA, US Session TD-A Themed Discussion Room 615

203 Mapping Vpx and Vpr Specificity in Antagonism of SAMHD1 Chelsea Spragg ; Michael Emerman Fred Hutchinson Cancer Research Center, Seattle, WA, US 202 A Surprising New Function of SAMHD1 as a Pro-Pathogenic Factor in HIV Infection Gilad Doitsh ; Nicole Galloway; Xin Geng; Isa Monus Arias; ZhiyuanYang;Warner C. Greene The J. David Gladstone Institute, University of California San Francisco, San Francisco, CA, US 191 Characterization of the Activity of an Innate Immunity Protein, the Apolipoprotein L6 Nitisha Pyndiah 1 ; Angela Ciuffi 1 ; AmalioTelenti 2 1 Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; 2 J Craig Venter Institute, San Diego, CA, US Session TD-H Themed Discussion Room 613 1:30 pm– 2:30 pm New Technologies in Assessing Drug Interactions and Systemic and Intracellular Pharmacology Themed Discussion Leader Tim R. Cressey , Harvard School of Public Health / Chiang Mai University, Chiang Mai, Thailand 531 Pharmacokinetic Interactions Between Antidiabetics and Efavirenz Using PBPK Modeling Catia Marzolini 1 ; Rajith Rajoli 2 ; Luigia Elzi 1 ; Manuel Battegay 1 ; David Back 2 ; Marco Siccardi 2 1 University Hospital Basel, Basel, Switzerland; 2 Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom 532 In Silico Simulation of Interaction Between Rifampicin and Boosted Darunavir Marco Siccardi ; Owain Roberts; Rajith Rajoli; Laura Dickinson; Saye Khoo; Andrew Owen; David Back University of Liverpool, Liverpool, United Kingdom 533 Pharmacogenetics of Pregnancy-Induced Changes in Efavirenz Pharmacokinetics Adeniyi Olagunju 1 ; Oluseye Bolaji 2 ; Alieu Amara 1 ; Laura Else 1 ; Ogechi Okafor 3 ; Ebunoluwa Adejuyigbe 2 ; Oyigboja Johnson 4 ; David Back 1 ; Saye Khoo 1 ; Andrew Owen 1 1 University of Liverpool, Liverpool, United Kingdom; 2 Obafemi Awolowo University, Ile-Ife, Nigeria; 3 Bishop Murray Medical Centre, Makurdi, Nigeria; 4 Catholic Caritas Foundation of Nigeria, Makurdi, Nigeria 534 Antiretroviral Drug Transporters and Metabolic Enzymes in Human Testicular Tissue Billy Huang 1 ; Md.Tozammel Hoque 1 ; Mohammad-Ali Jenabian 3 ; KishandaVyboh 2 ; Nancy Sheehan 2 ; Pierre Brassard 4 ; Maud Bélanger 4 ; Nicolas Chomont 5 ; Jean-Pierre Routy 2 ; Reina Bendayan 1 1 University of Toronto, Toronto, Canada; 2 McGill University, Montréal, Canada; 3 Université du Québec à Montréal, Montréal, Canada; 4 Metropolitan Centre of Plastic Surgery, Montréal, Canada; 5 Vaccine and Gene Therapy Institute of Florida, Port St Lucie, FL, US 535 Imaging the Spatial Distribution of Efavirenz in Intact HIV Tissue Reservoirs Elias P. Rosen 1 ; Corbin G.Thompson 2 ; MarkT. Bokhart 1 ; Craig Sykes 2 ;Yuri Fedoriw 2 ; Paul Luciw 3 ; David C. Muddiman 1 ; Angela D.M. Kashuba 2 1 North Carolina State University, Raleigh, NC, US; 2 University of North Carolina, Chapel Hill, NC, US; 3 University of California Davis, Davis, CA, US

Wednesday, February 25, 2015 • Oral Sessions

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CROI 2015