2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

RNA+ cells in Lymph node vs RNA in Plasma

10000000

1000000

Plasma Viral Load

100000

10000

1000

Plasma Viral Load (copies/ml) 10 100 <50

0.1

1

10

100

1000 10000

HIV RNA+ cells/10 6 LN cells

M Saag, UAB

Slide10of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

ARS Question 2: At steady state, when an actively producing cell dies, it is replaced by how many newly infected cells?

A. One B. Twenty-Five C. One Hundred D. One Thousand E. It depends on the viral load

Slide11of 39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDS ProgramCLINICALCONFERENCE, IAS  USA.

Slide12of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA. M Saag, UAB