2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

ARS Question 1: How many HIV virions are produced a day in an HIV infected person?

A. 1 B. ~ 1000 C. 570,342

D. ~ 1 million E. > 1 billion

Slide7of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

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Latently Infected CD4+ Lymphocytes

HIV Infected Cells

10 6

10 5

HIV virions

10 4

ViralLoad 10 3

10 2

T

=1.1days

1/2

10 1

Antiretroviral Rx

0

2

4

6

8

10

12

Weeks

Uninfected Activated CD4+ Lymphocytes

Uninfected Resting CD4+ Lymphocytes

M Saag, UAB

Slide9of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.