2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Roadmap ▪ Why do we care? ▫ HIV infected vs. uninfected, incidence

▪ MI types in HIV ▫ Universal MI definition ▫ CNICS MI adjudication ▫ Type 1 vs. Type 2 MIs ▪ Why ▪ Other CVD ▪ What do we do? ▫ Risk scores ▪ Summary

Slide28of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Strokes more common among PLWH

Chow FC, et al. JAIDS, 2012

Slide29of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Strokes in HIV

Hemorrhagic, 12%

▪ 75% Ischemic

Unidentifiable, 13%

▫ Small vessel 31%

▫ Cardioembolic 30%

Ischemic,75%

▫ Atheroembolic 23%

Other/ Unknown 16%

▫ Other/unknown 16%

Small vessel 31%

▪ 12% Hemorrhagic

Atheroembolic 23%

▪ 9% Case fatality rate

▪ 19% Current illicit drug use

Cardioembolic 30%

▪ 20% Infection

Slide30of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.