2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Causes of HIV-associated inflammation

Deeks SG,etal.Lancet2013

Slide25of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

MI risk 1.5-2.5 times greater in PLWH across CVD risk strata

100

PLWH

HIV uninfected

50

Acute MI rate (per 10,000p-y) 0

ALLRFs OPTIMAL

1+RFnot OPTIMAL

1+RF ELEVATED

2MAJOR RFs

3+MAJOR RFs

1MAJOR RF

Figure from: Paisible AL, etal. JAIDS 2015 Slide courtesy of M.Feinstein

Slide26of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

ART and MI risk

ElSadrW,etalNEJM 2006

Slide27of 43FromHMCrane, MD inNewOrleans, LA, December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.