CROI 2019 Abstract eBook

Abstract eBook

Poster Abstracts

these models were simulated for 5 years. The FRP was calculated at bimonthly intervals, by city and partnership type. Results: Across all partnership types, the median 5-year FRP was 0.998 in SF and 0.983 in ATL. In SF, a 50% FRP was achieved by week 2, whereas in ATL this took 5 weeks. This high temporal connectivity was largely driven by one-time partnerships: a 50% FRP was met through one-time partnerships within 2.5 years in ATL and in 0.9 years in SF. In casual partnerships, the 5-year FRP in ATL never reached 50% (median FRP: 3.8%), but in SF a 50% FRP was met within 4.5 years, with a median 5-year FRP of 61.1%. The median FRP for main partnerships was <0.01% in both cities. Conclusion: MSM in SF have higher FRPs, than do MSM in ATL, suggesting a greater epidemic potential in SF. However, SF and ATL have a similar HIV prevalence (22% and 24% in SF and ATL, respectively). Factors like differences in the use of HIV PrEP may differentially mitigate the effects of temporal network connectivity. One-time partnership networks, characterized by a high degree and short partnership duration, reached 50% of the population much faster than casual partnership networks. Focusing prevention efforts on casual partnerships, and among those with a high predicted FRP across partnerships, could be an effective disease control approach given currently available empirical data.

0.01)) and acculturated foreign-born Hispanic MSM (60% to 73% (p < 0.001)). An increase in STI diagnosis was significant among U.S. born Hispanic MSM (11% to 23% (p < 0.001)). Conclusion: While CAS increased overall and in U.S.-born and acculturated participants, the increase in STI diagnosis was only significant among U.S.-born MSM. These results suggest sexual risk among Hispanic MSMmay vary by experiences within the U.S. and mechanisms for STI transmission by nativity, even after adjusting for age and HIV status. Further research is needed to better understand how changes in sexual risk associate with changes in STIs differently by nativity status. However, HIV and STI prevention strategies for Hispanic MSM should recognize nativity status as an important factor in the lives of Hispanic MSM and consider tailored approaches.

Poster Abstracts

845 SUBSTANTIAL UNMET NEED FOR PrEP AMONG MSM IN HANOI

Ramona Bhatia 1 , Le Minh Giang 2 , Ly T. An 2 , Thai Thanh Truc 3 , Hao Bui 4 , Tran Khanh An 2 , Lung Bich Ngoc 2 , Diep T. Vu 1 , Abu Abdul-Quader 1 1 CDC Hanoi, Hanoi, Vietnam, 2 Hanoi Medical University, Hanoi, Vietnam, 3 Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam, 4 Kirby Institute, Sydney, NSW, Australia Background: Despite increasing HIV burden in MSM in Vietnam, PrEP is not publicly available. We describe the unmet PrEP need among Hanoi’s MSM using data from the Health in Men (HIM)-Hanoi Study. Methods: HIM-Hanoi is an ongoing, observational cohort study of sexually active MSM aged ≥16 years. The first wave was recruited via time-location sampling based on comprehensive mapping of MSM venues and enrolled from 7/17-12/17. We analyzed baseline demographic, behavioral, and bacterial STI testing data of the 720 MSM who tested HIV negative to identify those having at least one 2017 CDC recommended indication for PrEP. Weighted, stratified analysis was performed, taking into account variability of the venue size and selection probability. Six month follow-up data were used to identify MSM who seroconverted. Results: Mean age was 24.3 years[22.9-25.8], and most were employed (93.7%[88.3-96.7%]). Over half (53.7%[46.6-60.7%]) endorsed condomless anal intercourse (CAI) in the last six months. Few had recent injection drug use (2.1%[1.0-4.5%]) or a HIV-positive partner (4.4%[2.3-8.4%]). History of bacterial STI was reported by 15.3%[10.4-21.9%]; positive STI testing at baseline was common (38.1%[31.8-44.9%]). In all, 71.6%[65.9-79.7%] had at least one PrEP indication; 35.1%[28.7-42.1%] had two or more. CAI was the most common indication (48.7%[41.8-55.7%]), followed by previous or current STI (42.9%[36.1-50.0%]). Of 432 with six month follow-up data, 16(3.7%) MSM seroconverted; 13(81.3%) of these had at least one PrEP indication at baseline. Conclusion: Nearly three-quarters of MSM accessed through venues in Hanoi have an indication for PrEP, indicating a substantial unmet need. In addition

844 TRENDS IN HIV RISK BEHAVIORS OF HISPANIC MEN WHO HAVE SEX WITH MEN IN 19 US CITIES Lindsay Trujillo 1 , Monica Adams 2 , Amanda Smith 2 , Cyprian Wejnert 2 , for the NHBS Study Group 1 Oak Ridge Institute for Science and Education, Atlanta, GA, USA, 2 CDC, Atlanta, GA, USA Background: In 2015, Hispanics/Latinos accounted for about 25% of all new diagnoses of HIV in the US where a large proportion of those cases were among Hispanic men who have sex with men (MSM). However, risk behaviors among Hispanic MSM can vary by nativity status (i.e., location of birth and length of time in U.S.). We conducted a trend analysis to assess differences in HIV risk behaviors among Hispanic MSM within the continental U.S. by nativity status and acculturation using the National HIV Behavioral Surveillance (NHBS) system. Methods: MSM aged ≥ 18 years were sampled at venues in 19 U.S. cities, during 2011, 2014, and 2017. Analysis was limited to MSM who reported having ≥ 1 male sex partner within the past 12 months. Poisson regression with generalized estimating equations and clustered on recruitment event and city were conducted to assess changes in risk behaviors over time by nativity status, defined as being born in the continental U.S or not, and acculturation among foreign born, defined as residing in the U.S. more than 5 years. Estimates were adjusted for age and self-reported HIV status. Outcomes include condomless anal sex (CAS) and receiving a diagnosis of a sexually transmitted infection (STI) within the past 12 months. Results: Among Hispanic MSM, there was an increase in condomless anal sex (63% to 74% (p < 0.001)) and receipt of an STI diagnosis (11% to 21% (p < 0.001)) from 2011 to 2017. Trends in CAS and STI by nativity status are shown in the figure. Increases in CAS were significant among U.S. born (61% to 74% (p <

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