CROI 2025 Abstract eBook

Abstract eBook

Poster Abstracts

behavioral, clinical, and HIV care continuum characteristics to elucidate the experiences and needs of this population. Results: Among LS, 62% were female and 39% were male; 68% were > 25 years, and 34% were >30 years at the time of interview. In all, 90% were born in the US or Puerto Rico; 58% identified as Black, non-Hispanic and 26% as Hispanic or Latino; 38% obtained a high school or equivalent education, and 48% had more than a high school education. About 58% were currently employed, 18% were unemployed and 16% were unable to work. A majority (62%) had only public health insurance coverage, 31% had any private coverage and 7% had only Ryan White/AIDS Drug Assistance Program coverage. Household income was <100% of the federal poverty level for 50% of LS, 19% experienced hunger/food insecurity and 21% experienced unstable housing or homelessness. Most were very satisfied (83%) or somewhat satisfied (11%) with their healthcare. Overall, in the past 12 months: 93% of LS received any HIV care, 43% had sustained viral suppression; 22% had a nadir CD4 count of less than 200 cells/mm³ and 40% took all antiretroviral (ARV) doses in the past 30 days (Table). Conclusions: Although most LS received HIV care, fewer than half reported full ARV dose adherence, and a majority were not virally suppressed. Many were living in poverty. While a sizeable minority reported challenges meeting basic needs, most reported satisfaction with healthcare and being in good to excellent health. Assuring LS receive appropriate services to meet basic needs such as safe housing, food, and ARV adherence should be a public health priority. Additional research into the needs, health, and quality of life of LS is needed.

variable for multinomial regression analysis was viral load categories; primary outcome was LLV, defined as plasma HIV RNA 51- 999 copies/ml. Independent variables included WHO clinical stage at ART initiation, natal sex, initiated on dolutegravir (DTG), and country. Results: Viral load (VL) results were available for 6367 (51.3%) of 12,398 participants. The cohort (n=6367) was from 7 Programs in 5 West African countries. Most participants were from Ivory Coast (35%) and Benin (34%). Their mean age was 39(SD±11) years, and were predominantly female (60%). At enrollment, 5.4% were at WHO clinical stage 4, one-third were initiated on DTG-based ART. Rates for viral suppression and LLV were 78.7% and 11.3%, respectively. Factors found to be significantly associated with LLV at univariate analysis were male sex (p<.0001), WHO clinical stage (p<.0001), and country (p=0.001). There was a trend toward association for DTG-initiation (p=0.067). Participants at WHO stage 4 compared to WHO stage 1, had 2.044 (1.193, 3.505 p=0.0093) times odds of LLV at first VL result, post ART initiation, when adjusted for DTG initiation, sex, and country. Conclusions: WHO clinical stage four, male sex and country were found to have statistically significant association with LLV at first VL result. These findings provide critical information for targeted interventions to identify persons at risk of LLV in West Africa and mitigate adverse clinical consequences.

1173 WITHDRAWN

Poster Abstracts

1172 Clinical and Programmatic Factors Associated With Low-Level Viremia in West Africa Ebiere C. Herbertson 1 , Thierry Tiendrebeogo 2 , Karen Malateste 3 , Henri Chanal 4 , Eugène Messou 5 , Abert Minga 5 , Armel Poda 6 , Ephrem Mensah 7 , Oliver Ezechi 1 , Antoine Jaquet 2 , Ighovwerha Ofotokun 8 , Cecile D. Lahiri 8 , for the International Epidemiology Databases to Evaluate AIDS (IeDEA) Collaboration - West Africa 1 Nigerian Institute of Medical Research, Lagos, Nigeria, 2 University of Bordeaux, Bordeaux, France, 3 Bordeaux University Hospital, Bordeaux, France, 4 Integrated Center for Bioclinical Research, Abidjan, Côte d'Ivoire, 5 PAC-CI Program, Abidjan, Côte d'Ivoire, 6 Centre MURAZ, Bobo-Doulasso, Burkina Faso, 7 Centre Africain de Recherche en Épidémiologie et en Santé Publique, Lomé, Togo, 8 Emory University, Atlanta, GA, USA Background: Low-level viremia (LLV) is linked with poor outcomes in persons with HIV. Poor adherence to antiretroviral therapy (ART) is associated with LLV, but other factors may also contribute to LLV. This study aims to identify clinical and programmatic characteristics associated with LLV at the first viral load result post-ART initiation in West Africa. Methods: We conducted a retrospective cohort analysis of ART initiators (2016 2021) from the International Epidemiology Databases to Evaluate AIDS (IeDEA) West Africa collaboration. First values of viral load (12(±6) months post-ART initiation) were considered in the present analysis to define LLV. The response

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