CROI 2024 Program Guide

Interactive Symposia

Interactive Symposium-08 | Innovations in Intervention: Toward an HIV Cure 4:00 PM - 5:30 PM • Four Seasons Ballroom 1 CME Objectives: At the completion of the session, participants will be able to: • Describe how nonnucleoside reverse transcriptase inhibitor (NNRTI)-induced protease activity can activate inflammasome and eliminate HIV-infected cells • Summarize how single-cell transcriptomic analysis from clinical samples identifies potential therapeutic targets • Explain how structural understanding of HIV envelope protein conformation can lead to therapeutic strategies Target Audience: This session is directed to clinicians, researchers, and trainees interested in novel strategies for HIV cure. Level of Knowledge: It is assumed that the participants are familiar with the basic understanding of how HIV persists during antiretroviral therapy

Conveners Alberto Bosque , George Washington University, Washington, DC, USA María Buzón , Vall d’Hebron Research Institute, Barcelona, Spain

41 | 4:00 PM | From Mechanisms to Therapeutics: Eliminating HIV-Infected Cells by the CARD8 Inflammasome

Liang Shan , Washington University in St Louis, St Louis, MO, USA 42 | 4:15 PM | From Mechanisms to Therapeutics: TACK Molecules Kill HIV-Infected Cells Through Inflammasome Activation Tracy L. Diamond , Merck & Co., Inc., Rahway, NJ, USA 43 | 4:30 PM | From Transcriptomics to Therapeutics: A Host Restriction Factor That Targets HIV Expression Rasmi Thomas , Walter Reed Army Institute of Research, Silver Spring, MD, USA 44 | 4:45 PM | From Structure to Therapeutics: Small CD4 Mimetics ‘Open-Up’ Env and Sensitize HIV-1-Infected Cells Andrés Finzi , Université de Montréal, Montreal, Canada

Wednesday

5:00 PM | Audience Questions and Answers

CROI 2024 63

New Investigator Scholarship

LB

NIS

Late-Breaking