CROI 2019 Program and Conference Information

Oral Sessions

127 11:15 EFFECT ON PLASMA NFL, AMARKER OF NEURONAL INJURY, AFTER SWITCHING FROMTDF TO TAF Linn Hermansson, Richard W. Price, Aylin Yilmaz, Staffan Nilsson, Scott McCallister, Tariro Makadzange, Moupali Das, Henrik Zetterberg, Kaj Blennow, Magnus Gisslén CARDIOVASCULAR RISK SCORES PREDICT LONGITUDINAL COGNITIVE FUNCTION IN OLDER PLHIV Felicia C. Chow, Asya Lyass, Joseph Massaro, Virginia Triant, Kunling Wu, Baiba Berzins, Kevin Robertson, Ronald J. Ellis, Katherine Tassiopoulos, Babafemi Taiwo, Ralph D’Agostino Jeremiah Perez, Adriana Andrade, Ronald J. Ellis, Mary Clare Masters, Karl Goodkin, Susan L. Koletar, Frank J. Palella, Kevin Robertson, Ned Sacktor, Katherine Tassiopoulos, Kristine M. Erlandson Oral Abstract O-12 HIV/SIV AND THE IMMUNE SYSTEM: AN INTIMATE DANCE Room 6E 10:00 AM - 12:00 PM Oral Abstract Moderators Michael M. Lederman, Case Western Reserve University, Cleveland, OH, USA Gert U. van Zyl, Stellenbosch University, Cape Town, South Africa 130 HIGHHIV VIRAL BURDEN PERSISTS IN CXCR3+GCTFH DESPITE VERY EARLY ART INITIATION 11:30 11:45 10:00 128 129 OBESITY IS INDEPENDENTLY ASSOCIATEDWITH NEUROCOGNITIVE DECLINE INHIV Omolara Baiyegunhi, Jaclyn Mann, Adrienne Yanez, Geetha H. Mylvaganam, Krista Dong, Thumbi Ndungú, Bruce D. Walker, Zaza Ndhlovu SIROLIMUS REDUCES T-CELL CYCLING AND IMMUNE CHECKPOINTMARKER EXPRESSION, ACTG A5337 Timothy J. Henrich, Ronald Bosch, Catherine Godfrey, Hanna Mar, Apsara Nair, Elizabeth Hawkins, Carl Fichtenbaum, Michael Keefer, Jonathan Z. Li, Daniel R. Kuritzkes, Michael M. Lederman, Priscilla Hsue, Steven G. Deeks PD-1 AND CTLA-4 BLOCKADE INMACAQUES INDUCES T-CELL EXPANSION AND SIV REACTIVATION Justin L. Harper, Shari Gordon, Cristin Galardi, Hong Wang, Colleen S. McGary, Colin T. King, James Schawalder, Andrew Z. Sanderson, Brian A. Johns, Jeffrey D. Lifson, Jake D. Estes, David M. Margolis, Guido Silvestri, David Favre, Mirko Paiardini FTY720 LIMITS T FOLLICULAR HELPER CELL INFECTION IN LYMPHOID SITES OF SIV PERSISTENCE Maria Pino, Sara Paganini, Claire Deleage, Kartika Padhan, Justin L. Harper, Colin T. King, Luca Micci, Barbara Cervasi, Joseph Mudd, Sherrie M. Jean, Kirk A. Easley, Jacob D. Estes, Constantinos Petrovas, Michael M. Lederman, Mirko Paiardini TRANSCRIPTIONAL SIGNATURE OF LYMPHNODE CD8+T CELLS INHIV ELITE CONTROLLERS Son Nguyen, Claire Deleage, Sam Darko, Amy Ransier, Duc P. Truong, Divyansh Argawal, Alberto Sada Japp, Perla Del Río-Estrada, Ali Naji, Gustavo Reyes-Terán, Jacob D. Estes, Daniel Douek, Steven G. Deeks, Marcus Buggert, Michael R. Betts 131 10:15 132 10:30 133 10:45 134 11:00

Oral Sessions • Thursday

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