CROI 2017 Program and Information

Program and Agenda

Symposium S-4 CREATING AND DESTROYING HIV CAPSIDS Room 611-614 4:00 PM - 6:00 PM Target audience: This session is directed to clinicians and scientists who are interested in the assembly of HIV-1 particles and mature capsids, viral genome packaging and recognition of the mature HIV-1 capsid by the TRIM5alpha antiviral protein. Level of knowledge: It is assumed that participants are familiar with basic concepts in HIV-1 particle assembly and structure. Objectives: At the completion of the session, participants will be able to: • Describe how HIV-1 Gag assembles into immature particles and then transitions to a mature infectious form • Describe how variation in HIV-1 genomic RNA structure facilitates packaging of viral RNA into virions • Describe how RNA interactions with integrase are required for the correct maturation of virions • Describe how the TRIM5alpha protein recognizes the mature HIV-1 capsid Conveners Sebla Kutluay , Washington Univ in St. Louis, St Louis, MO, USA

Victoria D’Souza , Harvard Univ, Cambridge, MA, USA 92 THE FATES AND FOLDS OF HIV-1 RNA

4:00

Alice Telesnitsky , Univ of Michigan, Ann Arbor, MI, USA

93 STRUCTURE AND FUNCTION OF IMMATURE AND MATURE HIV CAPSIDS Hans-Georg Kräusslich , Heidelberg Univ, Heidelberg, Germany 94 A ROLE OF HIV-1 INTEGRASE IN ENCAPSIDATION OF THE VIRAL RNA GENOME Mamuka Kvaratskhelia , The Ohio State Univ, Columbus, OH, USA 95 TRIM5ALPHA RECOGNITION OF THE HIV CAPSID Barbie K. Ganser-Pornillos , Univ of Virginia, Charlottesville, VA, USA 4:30 5:00 5:30

Oral Sessions • Wednesday

CROI 2017 56