CROI 2017 Abstract e-Book

Abstract eBook

Poster and Themed Discussion Abstracts

Poster and Themed Discussion Abstracts

888

COMPARISON OF SELF-REPORT TO BIOMARKERS OF RECENT INFECTION Katherine E. Schlusser 1 , Shweta Sharma 2 , Pola de la Torre 3 , Giuseppe Tambussi 4 , Rika Draenert 5 , Angie N. Pinto 6 , Julia A. Metcalf 7 , Danielle German 1 , James Neaton 2 , Oliver Laeyendecker 7 1 The Johns Hopkins Univ, Baltimore, MD, USA, 2 Univ of Minnesota, Minneapolis, MN, USA, 3 Cooper Univ Hosp, Camden, NJ, USA, 4 Ospedale San Raffaele, Milano, Italy, 5 Klinikum der Univ Munich, Munich, Germany, 6 Kirby Inst, Sydney, Australia, 7 NIAID, Bethesda, MD, USA Background: Identifying individuals with recent HIV infection is critical to research related to viral reservoirs, outbreak investigations, and intervention applications. Currently, the reliability of self-report of recent infection is unknown. Methods: We tested samples from individuals of the Strategic Timing of Antiretroviral Treatment (START) trial for biomarkers associated with recent HIV infection. These included 3 groups: 1) 167 individuals who self-reported being infected < 6 months before enrollment (recent infection group); 2) 771 individuals with an unknown date of infection (unknown infection group), and 3) 199 randomly selected individuals who were diagnosed with HIV ≥2 years before enrollment (control group). Participants in the first two groups were diagnosed with HIV in the 6 months before enrollment. Samples from all individuals were tested by a multi assay algorithm (MAA), where subjects had to have a low titer and avidity (based on the Limiting-Antigen Avidity Assay), and detectable viral load to be classified as recently infected. Comparisons within groups were done using chi-square tests for proportions and Wilcoxon rank sum test for medians. Multivariate logistic regression was used to determine predictors of recent infection. Results: A significantly higher proportion of individuals in the self-reported recent infection group appeared recently infected by the MAA compared to individuals from the control group (65% [109/167] vs. 2.5% [5/199], p<0.001, see table), and had lower Limiting-Antigen Avidity Assay values (normalized optical density 1.86 [IQR 0.99, 3.01] vs. 4.53 [3.84, 4.99], p<0.001. Within the recent infection group, there were no significant differences in age, sex, race, geographic location, or HIV history when comparing those classified as recent versus not by the MAA. 27% (206/771) of individuals of the self-reported unknown infection group appeared recent by the MAA. Individuals who appeared recently infected by the MAA were similar, irrespective of knowing their infection date. Conclusion: Self-report of recency of infection seems reliable as a majority of such individuals’ claims were corroborated with biomarkers associated with that infection state. Discrepancies observed between self-report and biomarkers associated with recent HIV infection do not seem to be correlated with age, race, gender, geographic location, or HIV history.

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