CROI 2017 Abstract e-Book

Abstract eBook

Poster and Themed Discussion Abstracts

874 REDUCING ALCOHOL CONSUMPTION IMPROVED HIV VIRAL SUPPRESSION IN WOMEN Robert L. Cook 1 , Zhi Zhou 1 , Maria J. Miguez 2 , Babette Brumback 1 , John Lewis 3 , Luis Espinoza 3 , Kendall J. Bryant 4 1 Univ of Florida, Gainesville, FL, USA, 2 Florida Intl Univ, Miami, FL, USA, 3 Univ of Miami, Miami, FL, USA, 4 Natl Inst on Alcohol Abuse and Alcoholism, Bethesda, MD, USA Background: Alcohol use is common among persons living with HIV/AIDS (PLWH) and is associated with poor HIV-related outcomes. However, it is not clear whether interventions to reduce drinking will improve health outcomes among PLWH. We conducted an observational study of women participating in a randomized clinical trial to determine whether reduced drinking after alcohol intervention is associated with improvements in HIV viral suppression (NCT01625091). Methods: From December, 2012 to August, 2016 we enrolled 194 women with HIV infection who exceed recommended alcohol drinking levels (>7 drinks/week or ≥2 binge sections/month). Women were randomly assigned to receive oral naltrexone or placebo for 4 months. Alcohol consumption and HIV viral loads were assessed at 2-, 4-, and 7-months after enrollment. We analyzed data from 166 women who completed the 7 month visit. Women were categorized as “quitting heavy drinking” or not based whether they had reduced to non-heavy drinking (<7 drinks/week) or complete abstinence at the 7-month timepoint. Logistic regression models with propensity score weighting were constructed to determine whether quitting heavy drinking was associated with improved HIV viral load suppression (≤200 copies/mL). Results: Of the 166 women, 11%, 85%, and 4%were Hispanic, black, or white; the mean age was 48 years; and 96%were receiving antiretroviral therapy (ART). The majority of women (76%) had quit heavy drinking at 7 months. At baseline, there was no statistically significant difference in the quitters and non-quitters in HIV viral suppression (67% vs. 60%, p=0.44), or having >95% ART adherence (61% vs 59%, p=0.86). However, viral suppression improved over time in those who reduced drinking and the proportion of women with viral suppression at 7 months was significantly better in than those who quit vs. those who did not quit (74% vs. 54%, p=0.02). In the weighted logistic regression analysis, quitting heavy drinking was significantly associated with achieving HIV viral suppression (Adjusted OR: 2.62, 95% CI: 1.02, 6.69), when adjusting for baseline HIV viral load level. Conclusion: In this sample of heavy drinking women living with HIV, those who successfully reduced drinking were significantly more likely to achieve HIV viral suppression. The findings support continued efforts to screen and intervene to reduce hazardous drinking in persons with HIV, especially those who have not achieved consistent HIV viral suppression.

Poster and Themed Discussion Abstracts

CROI 2017 378