CROI 2016 Program at a Glance

Program and Agenda

Session S-1 Symposium

Room 304/306

Session S-2 Symposium

Ballroom A

CME

CME

4:00 PM-6:00 PM Molecular Interplay fromVirus to Host

4:00 PM-6:00 PM A Beautiful Mind: Keeping It

Target audience: This session is directed to clinicians and scientists who are interested in understanding HIV and its interactions with innate immune factors in mechanistic detail. Level of knowledge: It is assumed that participants are familiar with basic stages of the viral life cycle and the fundamentals of innate immunity. Objectives: At the completion of the session, participants will be able to: • Describe how HIV selects and packages its RNA genome • Describe how the viral Nef protein subverts clathrin and clathrin adaptor proteins to remove antagonizing cellular proteins from the plasma membrane • Describe the antiviral activity of the SERINC protein and how this protein is antagonized by HIV Nef and other retroviral proteins • Describe how the viral Vif protein recognizes antiviral APOBEC3 proteins for degradation Conveners Celia A. Schiffer ,Universityof MassachusettsMedicalSchool,Worcester, MA,USA Jonathan P. Stoye ,FrancisCrick Institute,USA 4:00 56 Structure of the HIV-1 RNA Packaging Signal Michael F. Summers, HowardHughesMed Inst,Minneapolis,MN,USA 4:30 57 The Antiretroviral Activity of the SERINC Gene Family Massimo Pizzato ,UnivofTrento,Trento, Italy

Target audience: This session is directed to clinicians and scientists who are interested in understanding the pathogenesis of HIV’s effect on the brain and its clinical implications. Level of knowledge: It is assumed that participants are familiar with basic and clinical concepts of how HIV impacts the CNS. Objectives: At the completion of the session, participants will be able to: • Describe the implications of viral reservoirs in the CNS for systemic and neurologic disease • Be familiar with CNS biomarkers of HIV immune activation • Describe the impact of antiretroviral therapies on the CNS • Critically evaluate CNS biomarkers of HIV brain disease Conveners Andrea Antinori, InstitutoNazionale Malattie Infettive“L.Spallanzani”, Rome, Italy Dana H. Gabuzda ,Dana-FarberCancer Institute,Boston,MA,USA 4:00 60 CNS HIV Infection: Cerebrospinal Fluid and Blood Biomarkers Magnus Gisslén ,UnivofGothenburg, Gothenburg,Sweden

Tuesday, February 23, 2016 • Oral Sessions

4:30 61 Neuroimaging of HIV in the Brain Beau M. Ances ,WashingtonUniv inSt. Louis,StLouis,MO,USA

5:00 62 CNS as an HIV Reservoir

Ronald I. Swanstrom ,UnivofNorth CarolinaatChapelHill,ChapelHill,NC,USA

5:00 58 How HIV-1 Nef Downregulation Hijacks Clathrin-Coated Vesicles James H. Hurley ,UnivofCaliforniaBerkeley, Berkeley,CA,USA 5:30 59 APOBEC3F-Vif Binding Interface Elucidated by Numerous Experimental Approaches Reuben S. Harris ,HowardHughesMed Inst, Minneapolis,MN,USA

5:30 63 Therapeutics of the CNS With HIV Infection Andrea Calcagno ,UnivofTorino, Torino, Italy

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CROI 2016