CROI 2015 Program and Abstracts

Poster Listings

894 Pharmacokinetics of Rilpivirine in HIV-InfectedWomen During Pregnancy and Postpartum Mark Mirochnick 1 ; Brookie M. Best 2 ; Alice Stek 3 ; Regis Kreitchmann 8 ; JiajiaWang 4 ; David Shapiro 4 ; Elizabeth Smith 5 ; Lynne Mofenson 6 ;Tim R. Cressey 7 ; Edmund Capparelli 2 1 Boston University School of Medicine, Hingham, MA, US; 2 University of California San Diego, San Diego, CA, US; 3 University of Southern California, Los Angeles, CA, US; 4 Harvard School of Public Health, Boston, MA, US; 5 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US; 6 Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, US; 7 Harvard School of Public Health/Chiang Mai University, Chang Mai, Thailand; 8 Irmandade da Santa Casa de Misericordia de Porto Alegre, Porte Alegre, Brazil 894-A Pharmacokinetics of Rifampin in TB/HIV-CoinfectedWomen: Does Pregnancy Matter? Paolo Denti 1 , Helen McIlleron 1 , Neil Martinson 2 , Silvia Cohn 2 , Jennifer Hoffmann 2 , Richard Chaisson 2 , Kelly Dooley 2 , Fildah Mashabela 3 , Regina Msandiwa 3 On behalf of theTSHEPISO StudyTeam 1 Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa; 2 Johns Hopkins University School of Medicine, Baltimore, Maryland, United States; 3 Perinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa

901 HIV and Smoking Associated with Shorter Telomere Length in a Cohort of Pregnant Women Sara Saberi 1 ; Beheroze Sattha 1 ; Evelyn Maan 2 ; JulieVan Schalkwyk 3 ; Deborah Money 1 ; Hélène Côté 1 On behalf of the CIHRTeam in Cellular Aging and HIV Comorbidities inWomen and Children (CARMA) 1 University of British Columbia, Vancouver, Canada; 2 BC Women’s Hospital and Health Centre, Vancouver, Canada; 3 Women’s Health Research Institute, Vancouver, Canada 902 Low Prolactin and High 20 α HSD May Contribute to cART-Induced P4 Deficits in Pregnancy Eszter Papp; Lena Serghides AAPHTeam Toronto General Research Institute, Toronto, Canada 2:30 pm– 4:00 pm Immune Mechanisms in MTCT 903 Generating HIV Neutralization in Milk With Neutralizing IgG/dIgA Antibodies Infusion Genevieve Fouda 1 ; Josh Eudailey 1 ; Erika Kunz 1 ; Joshua Amos 1 ; Jonathan Himes 1 ; Lisa Colvin 1 ; XinyueWang 2 ; Keith Reimann 2 ; Barton Haynes 1 ; Sallie Permar 1 1 Duke University, Durham, NC, US; 2 University of Massachusetts Medical School, Boston, MA, US 904 Specificity of V3-specific Neutralizing Responses in HIV-1 Infected Women David R. Martinez ; Genevieve Fouda; NathanVandergrift; Celia LaBranch; David Montefiori; Xiaoying Shen;Thomas Denny; GeorgiaTomaras; Sallie Permar Duke Human Vaccine Institute, Durhamc, NC, US 905 Broad, Highly Avid Vaccine-Elicited Anti-V1V2 IgG Responses in HIV- Exposed Infants Genevieve Fouda 1 ; Coleen Cunningham 1 ; Elizabeth McFarland 2 ; Bill Borkowsky 3 ; Nicole Yates 1 ; Erin McGuire 1 ; Hua-Xin Liao 1 ; Barton Haynes 1 ; GeorgiaTomaras 1 ; Sallie Permar 1 1 Duke University, Durham, NC, US; 2 University of Colorado, Aurora, CO, US; 3 New York University, New York, NY, US 906 Maternal Neutralization Escape Virus Variants Do Not Predict Infant HIV Infection Risk Caitlin Milligan 1 ; Maxwel Omenda 1 ;Vrasha Chohan 1 ; Katherine Odem-Davis 1 ; Barbra A. Richardson 1 ; RuthW. Nduati 2 ; Julie M. Overbaugh 1 1 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, US; 2 University of Nairobi, Nairobi, Kenya Session P-T11 Poster Session Poster Hall 2:30 pm– 4:00 pm PMTCT-Associated Drug Resistance inWomen and Infants 907 ART Failure and Resistance Among Pregnant and Post-PartumWomen in South Africa Christopher J. Hoffmann 1 ; Silvia Cohn 1 ; Fildah Mashabela 2 ; Jennifer Hoffmann 1 ; Kelly E. Dooley 1 ; Richard E. Chaisson 1 ; Neil Martinson 2 theTSHEPISO StudyTeam 1 Johns Hopkins University School of Medicine, Baltimore, MD, US; 2 Perinatal HIV Research Unit (PHRU), Johannesburg, South Africa 908 High Prevalence of HIV-1 Drug-Resistance Mutations in Subtype C Transmitting Mothers Detected Using 454 Ultra-Deep Sequencing Johanna Ledwaba 1 ; Anna Salimo 1 ; KarlTechnau 4 ; SimonTravers 3 ; Lynn Morris 1 ; Gillian Hunt 1 ; Louise Kuhn 2 1 National Institute for Communicable Diseases, National Health Laboratory Service, Sandringham, South Africa; 2 Columbia University, New York, NY, US; 3 University of the Western Cape, Modderdam, South Africa; 4 University of the Witwatersrand, Johannesburg, South Africa TUESDAY, FEBRUARY 24, 2015 Session P-T10 Poster Session Poster Hall

Session P-T8 Poster Session

Poster Hall

2:30 pm– 4:00 pm Planning and Preventing Pregnancy 895 Safer Conception Delayed by Lack of HIV Viral Suppression

Sheree R. Schwartz 1 ; Rebecca Phofa 2 ; NompumeleloYende 2 ; Jean Bassett 2 ; NoraWest 2 ; Ian Sanne 3 ; AnneliesVan Rie 1 1 University of North Carolina, Chapel Hill, NC, US; 2 Witkoppen Health and Welfare Centre, Johannesburg, South Africa; 3 University of the Witwatersrand, Johannesburg, South Africa 896 Preventing Unintended Pregnancy and HIV: The HIV Treatment Cascade and Contraceptive Choices Julia Raifman 1 ;Terusha Chetty 2 ; FrankTanser 2 ;Tinofa Mutevedzi 2 ; Philippa Matthews 2 ; Kobus Herbst 2 ; Deenan Pillay 2 ;Till Barnighausen 1 1 Harvard School of Public Health, Washington, DC, US; 2 Africa Centre for Health and Population Studies, Mtubatuba, South Africa

Poster Listings

THURSDAY, FEBRUARY 26, 2015 Session P-T9 Poster Session

Poster Hall

2:30 pm– 4:00 pm Mechanisms of MTCT and Maternal/Infant Health 897 HIV Target Cells and Altered Microbiome AssociatedWith Mixed Feeding in South Africa Lianna F. Wood 1 ; Cosette LeCiel 2 ; Heather Jaspan 3 ; Donald Sodora 2 1 University of Washington, Seattle, WA, US; 2 Seattle BioMed, Seattle, WA, US; 3 Seattle Children’s Hospital, Seattle, WA, US 898 Role of Type 1 IFNs in the Control of HIV-1 Infection at the Feto-Maternal Interface Erica L. Johnson ; Sahithi Boggavarapu; Elan S. Johnson; Asim A. Lal; Siddhartha Bhaumik; Murali-Krishna Kaja; Rana Chakraborty Emory University School of Medicine, Atlanta, GA, US 899 Immune Activation During Pregnancy and Postpartum Period in Treated HIV+ Ugandans Peter W. Hunt 1 ; Helen Byakwaga 2 ;Yap Boum 2 ; LynnT. Matthews 3 ;Tricia H. Burdo 4 ;Yong Huang 1 ; Annet Kembabazi 2 ; Angela Kaida 5 ; David R. Bangsberg 3 ; Jeffrey Martin 1 1 University of California San Francisco, San Francisco, CA, US; 2 Mbarara University of Science and Technology, Mbarara, Uganda; 3 Massachusetts General Hospital, Harvard Medical School, Boston, MA, US; 4 Boston College, Boston, MA, US; 5 Simon Fraser University, Vancouver, Canada 900 T-Cell Activation and Exhaustion in HIV-Infected and HIV-Uninfected Pregnant Women Christina Fiske ;Vlada Melekhin; Fernanda Maruri; Cindy Hager; Louise Barnett;Timothy Sterling; Spyros Kalams Vanderbilt University School of Medicine, Nashville, TN, US

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CROI 2015