CROI 2015 Program and Abstracts

Poster Listings

520 EFV but Not ATV/r Significantly Reduces Atovaquone Concentrations in HIV+ Subjects Monica M. Calderon 4 ; Joseph A. Kovacs 2 ; Alice K. Pau 2 ; Maryellen McManus 2 ; Raul Alfaro 1 ; Parag Kumar 1 ; Scott R. Penzak 3 1 National Institutes of Health (NIH), Bethesda, MD, US; 2 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US; 3 University of North Texas System College of Pharmacy, Forth Worth, TX, US; 4 US Food and Drug Administration (FDA), Silver Spring, MD, US Ka Lai Yee 3 ; Sauzanne G. Khalilieh 2 ; Rachael Liu 3 ; Rosa Sanchez 3 ; Matt S. Anderson 4 ; Candice Smith-Bradley 5 ; Joan Butterton 6 ;Timothy Judge 1 ; Helen Manthos 1 ; John Brejda 1 1 Celerion, Lincoln, NE, US; 2 Merck and Co, Inc, Kenilworth, NJ, US; 3 Merck and Co., Inc., West Point, PA, US; 4 Merck and Co, Inc, Rahway, NJ, US; 5 Merck and Co, Inc, Upper Gwynedd, PA, US; 6 Merck and Co, Inc, Boston, MA, US 522 Drug-Drug Interaction Between HCV Inhibitors Grazoprevir/Elbasvir With Dolutegravir Wendy W. Yeh 1 ;Ted Marenco 2 ; Hwa-Ping Feng 1 ; Zifang Guo 1 ; Daria Stypinski 2 ; Lisa Ross 3 ; Ivy H. Song 4 ; Patricia Jumes 1 ; Barbara Cook 2 ; Joan R. Butterton 1 1 Merck & Co, Inc, Boston, MA, US; 2 Celerion, Lincoln, NE, US; 3 ViiV Healthcare, Research Triangle Park, NC, US; 4 GlaxoSmithKline, Research Triangle Park, NC, US 523 HIV-1 Attachment Inhibitor Prodrug BMS-663068: Interactions with DRV/r and/or ETR Ishani Savant Landry ; XiaoluTao; Jeffrey Anderson; Michael Hesney; Michele Stonier; Susan Lubin; JianWang; George J. Hanna; DavidW. Boulton Bristol-Myers Squibb, Princeton, NJ, US 521 The Effect of Single and Multiple Dose Rifampin on the Pharmacokinetics of Doravirine 2:30 pm– 4:00 pm Pharmacokinetics in Compartments and Reservoirs and of Novel Formulations 524 Local and Systemic Pharmacokinetic Profile of Dapivirine Vaginal Ring-004When Used Continuously Over Various Periods up to Twelve Weeks Annalene M. Nel 1 ;Wouter Haazen 2 ; Marisa Russell 1 ; Jeremy P. Nuttall 3 ; NelietteVan Niekerk 1 ; NicolineTreijtel 4 1 International Partnership for Microbicides, Paarl, South Africa; 2 SGS Life Science Services, Antwerp, Belgium; 3 International Partnership for Microbicides, Silver Spring, MD, US; 4 Kinesis Pharma BV, Breda, Netherlands 525 Steady-state TDF/FTC in Genital, Rectal, and Blood Compartments in Males vs Females Sharon M. Seifert 1 ; Amie L. Meditz 2 ; Jose R. Castillo-Mancilla 3 ; Edward M. Gardner 3 ; Brandon Klein 1 ; Becky Kerr 1 ; L. Anthony Guida 1 ; Jia-Hua Zheng 1 ; Lane R. Bushman 1 ; Peter L. Anderson 1 1 University of Colorado, Aurora, CO, US; 2 Boulder Community Hospital, Boulder, CO, US; 3 University of Colorado School of Medicine, Aurora, CO, US 526 Effects of Tenofovir/Emtricitabine on Endogenous Deoxyribonucleotide Pools In Vivo Xinhui Chen 1 ; Kevin McAllister 1 ; Jia-Hua Zheng 1 ; Jose R. Castillo-Mancilla 1 ; Amie Meditz 2 ; Brandon Klein 1 ; Sharon M. Seifert 1 ; Lane Bushman 1 ; Peter L. Anderson 1 1 University of Colorado Anschutz Medical Campus, Aurora, CO, US; 2 Beacon Center of Infectious Diseases, Boulder, CO, US 527 Higher Cell Accumulation and Antiviral Activity of Lopinavir/Ritonavir Nanoparticles Philip Martin 1 ;Tom O. McDonald 2 ; Marco Giardiello 2 ; Steven P. Rannard 2 ; Andrew Owen 1 1 University of Liverpool, Liverpool, United Kingdom; 2 University of Liverpool, Liverpool, United Kingdom THURSDAY, FEBRUARY 26, 2015 Session P-H4 Poster Session Poster Hall

528 HIV reservoir targeted antiretroviral nanofabrication facilitates viral clearance Pavan Puligujja 1 ; JoEllyn McMillan 1 ; Shantanu Balkundi 2 ; Prasanta K. Dash 1 ; James Hilaire 1 ; Santhi Gorantla 1 ; Larisa Poluektova 1 ; Xin-Ming Liu 1 ; Howard Gendelman 1 1 University of Nebraska Medical Center, Omaha, NE, US; 2 Kansas University Innovation and Collaboration, Lawrence, KS, US 529 The Macrophage Proteome Defines the Long Acting Antiretroviral Therapy Cell Depot Dongwei Guo ; Mariluz Araínga; Jayme Horning; Pawel Ciborowski; Xin-Ming Liu; JoEllyn McMillan; Howard Gendelman University of Nebraska Medical Center, Omaha, NE, US 530 Primary CD4 Subsets Are Similarly Loaded by Tenofovir Alafenamide (TAF) Christian R. Frey;Yang Liu; Darius Babusis; Adam Palazzo; Adrian S. Ray; Michael D. Miller; Kathryn M. Kitrinos; Christian Callebaut Gilead Sciences, Inc., Foster City, CA, US Session P-H5 Poster Session Poster Hall 2:30 pm– 4:00 pm New Technologies in Assessing Drug Interactions and Systemic and Intracellular Pharmacology 531 Pharmacokinetic Interactions Between Antidiabetics and Efavirenz Using PBPK Modeling Catia Marzolini 1 ; Rajith Rajoli 2 ; Luigia Elzi 1 ; Manuel Battegay 1 ; David Back 2 ; Marco Siccardi 2 1 University Hospital Basel, Basel, Switzerland; 2 Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom 532 In Silico Simulation of Interaction Between Rifampicin and Boosted Darunavir Marco Siccardi ; Owain Roberts; Rajith Rajoli; Laura Dickinson; Saye Khoo; Andrew Owen; David Back University of Liverpool, Liverpool, United Kingdom 533 Pharmacogenetics of Pregnancy-Induced Changes in Efavirenz Pharmacokinetics Adeniyi Olagunju 1 ; Oluseye Bolaji 2 ; Alieu Amara 1 ; Laura Else 1 ; Ogechi Okafor 3 ; Ebunoluwa Adejuyigbe 2 ; Oyigboja Johnson 4 ; David Back 1 ; Saye Khoo 1 ; Andrew Owen 1 1 University of Liverpool, Liverpool, United Kingdom; 2 Obafemi Awolowo University, Ile-Ife, Nigeria; 3 Bishop Murray Medical Centre, Makurdi, Nigeria; 4 Catholic Caritas Foundation of Nigeria, Makurdi, Nigeria 534 Antiretroviral Drug Transporters and Metabolic Enzymes in Human Testicular Tissue Billy Huang 1 ; Md.Tozammel Hoque 1 ; Mohammad-Ali Jenabian 3 ; KishandaVyboh 2 ; Nancy Sheehan 2 ; Pierre Brassard 4 ; Maud Bélanger 4 ; Nicolas Chomont 5 ; Jean-Pierre Routy 2 ; Reina Bendayan 1 1 University of Toronto, Toronto, Canada; 2 McGill University, Montréal, Canada; 3 Université du Québec à Montréal, Montréal, Canada; 4 Metropolitan Centre of Plastic Surgery, Montréal, Canada; 5 Vaccine and Gene Therapy Institute of Florida, Port St Lucie, FL, US 535 Imaging the Spatial Distribution of Efavirenz in Intact HIV Tissue Reservoirs Elias P. Rosen 1 ; Corbin G.Thompson 2 ; MarkT. Bokhart 1 ; Craig Sykes 2 ;Yuri Fedoriw 2 ; Paul Luciw 3 ; David C. Muddiman 1 ; Angela D.M. Kashuba 2 1 North Carolina State University, Raleigh, NC, US; 2 University of North Carolina, Chapel Hill, NC, US; 3 University of California Davis, Davis, CA, US

Poster Listings

44

CROI 2015