CROI 2015 Program and Abstracts

Abstract Listing

Poster Abstracts

Conclusions: TIs were frequent in patients in ART programs in LMICs and associated with younger age, female gender and more advanced HIV. Further evaluation of predictors of TI and interventions to reduce their occurrence are warranted in all LMICs. 1012 Time to ART Qualification and Retention Among Patients With Early HIV in Haiti Rita T. Dadaille 1 ; Serena P. Koenig 1 ; Kelley Henessey 2 ; Ellie Cooper 2 ; Pierre Cremieux 2 ;William J. Pape 1 Analysis Group; Les Centres GHESKIO ITTeam 1 Gheskio Centers, Port au Prince, Haiti; 2 Analysis Group, Boston, MA, US Background: Attrition is high from HIV testing to antiretroviral therapy (ART) initiation, particularly among patients who do not yet qualify for ART. We evaluated pre-ART outcomes for patients with early HIV over the last decade at the GHESKIO Center in Port-au-Prince, Haiti. Methods: We included all adult patients (age ≥ 18 years) who tested positive for HIV fromMarch 2003 through February 2012. We calculated retention from HIV testing to ART initiation, with 2 years of pre-ART follow-up. In addition, among patients with CD4 >500 cells/mm 3 , we conducted multivariate analyses to evaluate predictors of patient retention, and analyzed the time to CD4 cell count ≤ 500 cells/mm 3 . Results: A total of 22,317 patients received positive HIV test results; 13,574 (61%)were female, with median age of 35 years. Of patients who tested HIV-positive, 14,398 (65%) had blood drawn for CD4 count, an increase of 56% from year 1 (48%) to year 9 (75%). Overall, 13,047 (91%) returned for results and3,061 patients (89%) had CD4 count >500 cells/ mm 3 . Among patients with CD4 count >500 cells/mm 3 , 1,591 (46%) were retained in pre-ART care for ≥ 2 years or initiated ART. Predictors of retention included later year of HIV testing (OR 1.04; 95% CI: 1.01-1.08), education (primary vs. none: OR 1.48; 95% CI: 1.23-1.77), female gender (OR 1.46; 95% CI: 1.23-1.74), relationship status (stable partnership vs. single: OR 1.41; 95% CI: 1.16-1.71), residence zone in Port-au-Prince (OR 1.39; 95% CI: 1.04-1.85), and TB after enrollment (OR 3.44; 95% CI: 2.29-5.18). The median time to CD4 count ≤ 500 cells/mm3 was 19.9 months (see Figure 1).

Poster Abstracts

595

CROI 2015