CROI 2015 Program and Abstracts

Abstract Listing

Poster Abstracts

Conclusions: Almost one third of MSM is currently diagnosed with a recent infection, but in other groups, diagnosis of a recent infection remains uncommon. The proportion who started cART ≤ 6 months at high CD4 counts has rapidly increased in recent years, reflecting the adoption by both physicians and patients of changes in treatment guidelines. 1008 Estimates of HIV Prevalence, Proportion of Diagnosed Patients and Quality of Treatment in Switzerland Philipp Kohler 2 ; Axel J. Schmidt 3 ; Bruno Ledergerber 2 ; Pietro L. Vernazza 1 1 Cantonal Hospital St. Gallen, St. Gallen, Switzerland; 2 Universitätsspital Zürich, Zurich, Switzerland; 3 Federal Office of Public Health, Bern, Switzerland Background: A recently published review article on the quality of HIV-care in the US showed that a considerable number of HIV infected individuals is either unaware of their diagnosis or not adequately treated. We aimed at conducting a similar analysis estimating the HIV prevalence, the proportion of diagnosed patients and the quality of HIV care in Switzerland. Methods: Four levels of engagement in HIV-care were defined: a) HIV infected, b) HIV diagnosed, c) on antiretroviral treatment (ART), and d) with suppressed viral load (i.e. <200 RNA copies per ml). The Swiss HIV Cohort Study (SHCS) database was used to determine the proportion of treated SHCS patients including those with suppressed viral load. Furthermore, a survey among HIV care providers connected to the SHCS network was conducted regarding the proportion of treated non-SHCS patients (including those with suppressed viral load) within the SHCS network. The number of HIV-patients being treated outside the SHCS network was estimated based on ART sales data for Switzerland. Based on the total number of SHCS and non-SHCS patients being linked to care, we inferred the number of non-diagnosed HIV patients from a model reported by Van Sighem et al. 2011 for MSM . For other transmission categories, a proportion of 25% undiagnosed individuals was assumed. Results: In 2012, we estimate (a) 15,200 individuals infected with HIV living in Switzerland, corresponding to an overall prevalence of 0.19%. Of those, (b) 12,800 (84%) had been diagnosed. Based on sales data, adjusted for treatment change, adherence and PEP use, 11,100 patients (c) were receiving ART (87%), and 10,500 (d) had an undetectable viral load (95%). This results in an overall proportion of undetectable viral load of 69%. A vast majority of Swiss HIV patients (87%) was followed within the SHCS network, with an overall percentage of 70% registered in the SHCS.

Poster Abstracts

Conclusions: The effectiveness of ART for patients within the SHCS network is high with a suppression rate of 95%. Interventions aiming at improving the current situation of HIV management in Switzerland will most likely have the greatest impact if applied to infected persons unaware of their diagnosis. Currently, one third of the HIV-infected population can serve as a source for onward transmission, half of which don’t know their status. 1009 Medical Care Interruptions in HIV-infected Patients: Characteristics and Consequences Lise Cuzin 1 ; Pierre Dellamonica 2 ;YazdanYazdanpanah 7 ; Sabelline Bouchez 3 ; David Rey 6 ; Bruno Hoen 5 ; André Cabié 4 1 Toulouse University Hospital, Toulouse, France; 2 University Hospital, Nice, Nice, France; 3 University Hospital, Nantes, France; 4 University Hospital, Fort de France, France; 5 University Hospital, Pointe à Pitre, France; 6 University Hospital, Strasbourg, France; 7 Hôpital Bichat-Claude Bernard, APHM, Paris, France Background: To describe the consequences of medical care interruptions in a French cohort of HIV infected patients. Methods: Retrospective study nested in the prospective Dat’AIDS cohort, which collects all medical and therapeutic information on HIV-infected patients in care in major University Hospitals in France.

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CROI 2015