CROI 2015 Program and Abstracts

Poster Listings

WEDNESDAY, FEBRUARY 25, 2015 Session P-E3 Poster Session

361 Nef Plays a Role in the Resistance of SIV-Infected Macrophages to CD8 + T-Cell Suppression Jennifer N. Rainho ; Mauricio A. Martins; Francesc Cunyat; David I.Watkins; Mario Stevenson University of Miami, Miami, FL, US 362 Defining Efficacious HIV-Specific CTL Responses Using Saporin- Conjugated Tetramers Ellen M. Leitman 1 ; Stuart Sims 2 ; Rebecca P. Payne 1 ; Fabian Chen 3 ; Lynn Riddell 4 ; Soren Buus 5 ; Steven Deeks 6 ; BruceWalker 7 ; Philippa C. Matthews 1 ; Philip J. Goulder 1 1 University of Oxford, Oxford, United Kingdom; 2 ETH Zurich, Basel, Switzerland; 3 Royal Berkshire Hospital, Reading, United Kingdom; 4 Northamptonshire Healthcare NHS Trust, Northampton, United Kingdom; 5 University of Copenhagen, Copenhagen, Denmark; 6 University of California San Francisco, San Francisco, CA, US; 7 Ragon Institute of MGH, MIT and Harvard, Charlestown, MA, US 363 Linking Pig-Tailed Macaque Major Histocompatibility Complex Class I Haplotypes and Cytotoxic T Lymphocyte Escape Mutations in SIV Infection Shayarana Gooneratne 1 ; Hamid Alinejad-Rokny 2 ; Diako Ebrahimi Mohammadi 2 ; Patrick Bohn 3 ; RogerWiseman 3 ; David O’Connor 3 ; Miles Davenport 2 ; Stephen Kent 1 1 University of Melbourne, Melbourne, Australia; 2 University of New South Wales, Kensington, Australia; 3 University of Wisconsin Madison, Madison, WI, US 364 HLA Class-II – Associated HIV Polymorphisms Predict Escape From CD4 T-Cell Responses Nathaniel B. Erdmann 1 ;Victor Du 1 ; Jonathan M. Carlson 2 ; John Sidney 3 ; LingYue 4 ; Susan Allen 4 ; Eric Hunter 4 ; Sonya L. Heath 1 ; Anju Bansal 1 ; Paul A. Goepfert 1 1 University of Alabama at Birmingham, Birmingham, AL, US; 2 Microsoft Research, Los Angeles, CA, US; 3 La Jolla Institute of Allergy and Immunology, La Jolla, CA, US; 4 Emory University, Atlanta, GA, US 365 Rapid Construction of HIV-1-Specific T Cell Receptor Gene Therapy Lentiviral Vectors Christian Hofmann ; Christian-Raul Aguilera-Sandoval; Arumugam Balamurugan; Priya Patel; Brian Diep; Edward Martin; Sangeun Park; DianaY. Chen; Hwee Ng; Otto O.Yang University of California Los Angeles, Los Angeles, CA, US 366 The Role of Exosomes in Semen in Suppressing Natural and Vaccine- Induced Immunity Lucia Vojtech ; Sean Hughes; Claire Levy; Florian Hladik University of Washington, Seattle, WA, US 367 IFN-alpha Stimulated NK Lysis of HIV-Infected CD4 + T Cells Requires NKp46 and NKG2D Costin Tomescu 1 ; Domenico Mavilio 2 ; Luis J. Montaner 1 1 The Wistar Institute, Philadelphia, PA, US; 2 Humanitas Clinical and Research Center, Milan, Italy 2:30 pm– 4:00 pm Immune-Based Strategies in Latency 368 Stimulation of Broad CTL Response Is Required to Clear Latent HIV-1 in Humanized Mice Liang Shan 1 ; Kai Deng 2 ; Richard Flavell 1 ; Robert F. Siliciano 2 1 Yale University, New Haven, CT, US; 2 Johns Hopkins University School of Medicine, Baltimore, MD, US 369 In vivo effects of Panobinostat and Romidepsin on HIV-1-specific CD8 T Cell Immunity Rikke Olesen 1 ;Thomas A. Rasmussen 1 ; Mathias Lichterfeld 2 ; Mette E. Graversen 1 ; Steffen Leth 1 ; Lars Østergaard 1 ; Ole S. Søgaard 1 ; MartinTolstrup 1 1 Aarhus University Hospital, Aarhus, Denmark; 2 Ragon Institute of MIT, MGH and Harvard, Boston, MA, US TUESDAY, FEBRUARY 24, 2015 Session P-F1 Poster Session

Poster Hall

2:30 pm– 4:00 pm New Approaches to Immunostimulation 352 Use of Pre-ART-Adjusted Endpoints in the Analysis of an HIV Therapeutic Vaccine Trial Yunda Huang 1 ; Lily Zhang 1 ; Darren Jolliffe 3 ; Arnt-Ove Hovden 4 ; Mats Okvist 4 ; Pantaleo Giuseppe 2 ; Maja A. Sommerfelt 4 1 Fred Hutchinson Cancer Research Center, Seattle, WA, US; 2 Lausanne University Hospital, Lausanne, Switzerland; 3 S-cubed Biometrics Ltd, Oxfordshire, United Kingdom; 4 Bionor Pharma ASA, Oslo, Norway 353 Decreased HIV-Specific T-Regulatory Responses Mark Effective Vaccine- Induced Immunity Vedran Brezar 1 ; Nicolas Ruffin 1 ; Laura Richert 2 ; Mathieu Surenaud 1 ; Christine Lacabaratz 1 ; Karolina Palucka 3 ; RodolpheThiebaut 2 ; Jacques Banchereau 1 ;Yves Lévy 1 ; Nabila Seddiki 1 1 Inserm U955 (Eq16)-UPEC-VRI, Créteil, France; 2 Univ Bordeaux-ISPED-Inserm U897-VRI, Bordeaux, France; 3 Ralph M. Steinman Center for Cancer Vaccines–Baylor Institute for Immunology Research, Dallas, TX, US 354 Viral Reservoir Dynamics After Therapeutic Vaccination and cART Interruption Cristina Andres 1 ; Carmen Alvarez-Fernandez 1 ; Nuria Climent 1 ;Teresa Gallart 1 ; Montserrat Plana 1 ; Agathe Leon 1 ; Nicolas Chomont 2 ; Jose M. Gatell 1 ; Felipe Garcia 1 ; Sonsoles Sanchez- Palomino 1 1 Hospital Clinic, Barcelona, Spain; 2 Vaccine and Gene Therapy Institute, Port St Lucie, FL, US 355 HIV-1 Envelope Epitope Recognition Is Influenced by Immunoglobulin D H Gene Segment Repertoire YugeWang 2 ; Aaron Sanchez-Silva 2 ; Barton Haynes 1 ; Harry Schroeder 2 1 Duke University, Durham, NC, US; 2 University of Alabama at Birmingham, Birmingham, AL, US; 3 University of Alabama at Birmingham, Birmingham, AL, US 356 Human Rhinovirus Displaying HIV-1 4E10 Epitope Elicits Broad Neutralization in hICAM-1 Tg Mice Guohua Yi 1 ; XiongyingTu 2 ; Preeti Bharaj 1 ; Premlata Shankar 1 ; Manjunath Swamy 1 1 Texas Tech University Health Sciences Center, El Paso, TX, US; 2 University of Minnesota, St Paul, MN, US 357 WITHDRAWN 358 A Superagonist Antibody to Human Interleukin-21 Increases HIV-Specific T-Cell Function Yew Ann Leong 1 ;Yanfang Cui 1 ; Zhian Chen 1 ; FionaWightman 1 ; Pellegrini Marc 2 ; Jamie Rossjohn 1 ; Sharon R. Lewin 3 ; Alan Landay 4 ; Charles Mackay 1 ; DiYu 1 1 Monash University/Alfred Hospital, Melbourne, Australia; 2 Walter and Eliza Hall Institution, Melbourne, Australia; 3 University of Melbourne, Melbourne, Australia; 4 Rush University Medical Center, Chicago, IL, US; 5 Monash University/Alfred Hospital, Melbourne, Australia 2:30 pm– 4:00 pm Cellular Immune Response to HIV 359 Evolution of HIV-Specific CD8+ T-Cell Responses in Hyperacute HIV Infection Zaza M. Ndhlovu 1 ; Nikoshia Mewalal 1 ; Philomena Kamya 1 ;Thandeka Nkosi 1 ; Karyn Pretorius 1 ; Nasreen Ismail 1 ; Amber Moodley 2 ; Krista Dong 2 ;Thumbi Ndung’u 1 ; BruceWalker 2 1 University of KwaZulu-Natal, Durban, South Africa; 2 Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, US 360 Nonclassical Regulatory HIV-1 – Specific CD8 T Cells in HIV-1 Disease Progression Selena Vigano 2 ; Chun Li 2 ; Jordi J. Negron 2 ; Bruce D.Walker 2 ; Mathias Lichterfeld 1 ; Xu G.Yu 2 1 Massachusetts General Hospital, Boston, MA, US; 2 The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, US THURSDAY, FEBRUARY 26, 2015 Session P-E4 Poster Session Poster Hall

Poster Listings

Poster Hall

34

CROI 2015