CROI 2015 Program and Abstracts

Abstract Listing

Poster Abstracts

Poster Abstracts

Table 1: Demographics, clinical characteristics and pulse-wave velocity. Conclusions: Despite significantly elevated lipids and prolonged LPVr-based ART exposure, arterial elasticity was no different in HIV+ school-age children and uninfected controls. Early ART may prevent early HIV-related inflammatory vascular damage. 927 The Impact of HIV and ART on Markers of Inflammation, Vascular Injury and Disordered Thrombogenesis in Children Julia M. Kenny 1 ; SarahWalker 1 ; Adrian Cook 1 ;Victor Musiime 2 ; PriscillaWavamunno 2 ; Florence Odongo 2 ; Grace Mirembe 2 ; Dorica Masaku 3 ; Diana M. Gibb 1 ; Nigel J. Klein 1 1 University College London, London, United Kingdom; 2 Joint Clinical Resarch Centre, Kampala, Uganda; 3 University Teaching Hospital, Lusaka, Zambia Background: Markers of inflammation are generally increased in HIV-infected individuals. However, few data are available from young African children and longitudinal data are sparse. Methods: ART naïve and ART experienced (on d4T+3TC+NNRTI for >2 years, virologically suppressed) children from the CHAPAS-3 trial in Uganda/Zambia were included, with age-matched controls. A panel of biomarkers to measure inflammation (IL1Ra, high sensitivity CRP, IL6, IL8, IL10 and TNFa), vascular injury (thrombomodulin(TM), E-selectin, P-selectin, serum amyloid A (SAA), VCAM1, ICAM1, MCP1, VEGF and angiopoietin(Ang) 1+2) and disordered thrombogeneis (d-dimers, soluble tissue factor(TF)) were measured at baseline in all children and repeated at 48 and 96 weeks in the HIV-infected children. Associations between change in log10 biomarkers fromweek 0 to 96 and baseline VL and age, and VL suppression at week 96, were estimated using normal linear regression. Results: 208 HIV infected ART naïve, 74 HIV infected ART experienced and 284 HIV uninfected controls were recruited. At baseline 13/19 biomarkers were significantly (p<0.05) higher in the ART naïve vs controls, ART experienced vs controls and ART naïve vs ART experienced. TM and TF levels were similar in ART naïve and controls. In the experienced group, after a mean 3.7 years on ART baseline levels of IL1Ra, SAA and sICAMwere comparable to controls. Baseline Ang-1 levels were similar in ART naïve and experienced children but higher than controls. By week 96, all biomarkers had significantly declined excepting SAA, Ang-1 and 2 in the ART naïve group and P-selectin in the ART experienced group. In naïve children, the only biomarkers for which declines to week 96 were not greater in children with VL<100 c/ml at week 96 compared to those >100 c/ml were TM, Ang-1 and TF (p>0.1) (Figure). For IL10, TNFa, MCP, SAA, VCAM, VEGF, Ang-2 declines to week 96 were independently greater in older children (p<0.1). Fewer biomarker declines were associated with week 96 VL<100 c/ml in experienced children. There was no independent effect of baseline VL on week 96 declines in any biomarker (p>0.1).

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CROI 2015