CROI 2015 Program and Abstracts

Oral Sessions

858 CCR5 Expression in HIV-UninfectedWomen Receiving Hormonal Contraception Athe Tsibris 1 ; Gaia Sciaranghella 2 ; CuiweiWang 3 ; Kerry Murphy 4 ; Zaher Mehri 5 ; Ruth M. Greenblatt 6 ; Mardge Cohen 7 ; Elizabeth Golub 8 ; HeatherWatts 9 ; Mary A.Young 3 1 Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA, US; 2 Ragon Institute of MIT, MGH and Harvard, Boston, MA, US; 3 Georgetown University Medical Center, Washington, DC, US; 4 Albert Einstein College of Medicine, Bronx, NY, US; 5 University of Vermont College of Medicine, Burlington, VT, US; 6 University of California San Francisco, San Francisco, CA, US; 7 Stroger Hospital and Rush University and CORE Center, Chicago, IL, US; 8 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 9 The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, US 860 Progesterone Increases Are AssociatedWith HIV Susceptibility Factors in Women AlisonY. Swaims 1 ;Tammy Evans-Strickfaden 1 ; L Davis Lupo 1 ; Alfredo Aguirre 2 ; Anandi Sheth 2 ; Igho Ofotokun 2 ; Clyde E. Hart 1 ; Richard E. Haaland 1 1 US Centers for Disease Control and Prevention (CDC), Atlanta, GA, US; 2 Emory University School of Medicine, Atlanta, GA, US 861 Changes in Vaginal Microbiota and Cytokines in HIV-1-Seronegative Women Initiating DMPA Alison C. Roxby 1 ; David N. Fredricks 2 ; Katherine Odem-Davis 1 ; Kristjana H. Ásbjörnsdóttir 1 ; Linnet Masese 1 ;Tina L. Fiedler 2 ;Walter Jaoko 3 ; James N. Kiarie 3 ; Julie M. Overbaugh 2 ; R Scott McClelland 1 1 University of Washington, Seattle, WA, US; 2 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, US; 3 University of Nairobi, Nairobi, Kenya Emmanuel Njeuhmeli , US Agency for International Development (USAID), Douglasville, GA, US 1086 Mobile VMMC Teams in Tanzania See Older Clients and Have Higher Followup Rates Augustino M. Hellar 1 ; Dorica Boyee 1 ; Hally Mahler 1 ; Marya Plotkin 1 ;Touma Ng’wanakilala 1 ; Kelly Curran 2 ;Tigistu Ashengo 2 ; Hawa Mziray 1 ; Erick Mlanga 3 ; Sifuni Koshuma 4 1 Jhpiego, Dar es Salaam, United Republic of Tanzania; 2 Jhpiego, Baltimore, MD, US; 3 US Agency for International Development, Dar es Salaam, United Republic of Tanzania; 4 Ministry of Health and Social Welfare, Iringa, United Republic of Tanzania 1087 High Acceptability of PrePex™ Device in Routine Programmatic Settings in Rwanda Eugene Rugwizangoga 1 ; Beata Mukarugwiro 1 ; Jovite Sinzahera 1 ; Alphonse Mutabaruka 1 ; Gloriose Abayisenga 1 ; J.D. Ntakakirabose 1 ; Ngeruka Leon 4 ; Eugene Zimulinda 3 ; Kelly Curran 2 ; Tigistu Ashengo 2 1 Jhpiego/Rwanda, Kigali, Rwanda; 2 Jhpiego, an Affiliate of Johns Hopkins University, Washington, DC, US; 3 US Department of Defense, Rwanda, Kigali, Rwanda; 4 Rwanda Military Hospital, Kigali, Rwanda 1089 Potential Protection FromHIV Transmission by Penile Cuttings in Papua New Guinea Ivy H. Shih 1 ; Lester Asugeni 2 ; Matthew David 5 ; Paul Horwood 5 ; Parana Hewage Mangalasir 3 ; David Mc Laren 3 ; RachaelTommbe 2 ; AndrewVallely 1 ; ArnoldWaine 4 ; Stuart G.Turville 1 1 The Kirby Institute, Sydney, Australia; 2 Pacific Adventist University, Port Moresby, Papua New Guinea; 3 James Cook University, Cairns, Australia; 4 University of Papua New Guinea, Port Moresby, Papua New Guinea; 5 Papua New Guinea Institute of Medical Health, Goroka, Papua New Guinea 1084 HSV-2 Shedding FromMale CircumcisionWounds Among HIV-Infected Men Mary K. Grabowski 1 ; Godfrey Kigozi 2 ; Ronald H. Gray 1 ; Jordyn L. Manucci 3 ; David Serwadda 4 ; Eshan U. Patel 3 ; Fred Nalugoda 2 ; Maria J.Wawer 1 ;Thomas C. Quinn 5 ; Aaron A. Tobian 3 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 2 Rakai Health Sciences Program, Kalisizo, Uganda; 3 Johns Hopkins University School of Medicine, Baltimore, MD, US; 4 Makerere University College of Health Sciences, Kampala, Uganda; 5 National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, MD, US Session TD-Y Themed Discussion Room 6E 1:30 pm– 2:30 pm Circumcision: Evolving Knowledge and Practice Themed Discussion Leader

1088 Self-Selection of Circumcision Acceptors, Risk Compensation and Effectiveness of Circumcision Among Service Recipients, Rakai, Uganda Joseph Kagaayi 1 ; Xiangrong Kong 2 ; Godfrey Kigozi 1 ; Fred Nalugoda 1 ; Steven J. Reynolds 3 ; David Serwadda 4 ; Nelson K. Sewankambo 5 ; Maria J.Wawer 2 ; Ronald H. Gray 2 1 Rakai Health Sciences Program, Entebbe, Uganda; 2 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, US; 3 Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, US; 4 Makerere University School of Public Health, Kampala, Uganda; 5 Makerere University College of Health Sciences, Kampala, Uganda

Session O-5 Oral Abstracts

Room 613

4:00 pm– 6:00 pm NeuroAIDS Pathogenesis and Antiretroviral Therapy Moderators

Tuesday, February 24, 2015 • Oral Sessions

Lucette A. Cysique , NeuRA, UNSW Australia, Randwick, NSW, Australia Alan Winston , Imperial College London, London, United Kingdom 56 Randomized Clinical Trial of Antiretroviral Therapy for Prevention of HAND Fujie Zhang 1 ; Robert Heaton 2 ; HaoWu 3 ; Hua Jin 2 ; Hongxin Zhao 4 ; XinYu 5 ; Donald Franklin 2 ; Weiwei Mu 1 ; FlorinVaida 2 ; Scott Letendre 2 1 Chinese Center for Disease Control and Prevention, Beijing, China; 2 University of California San Diego (UCSD), San Diego, CA, US; 3 Capital Medical University, Beijing You’an Hospital, Beijing, China; 4 Capital Medical University Beijing Ditan Hospital, Beijing, China; 5 Peking University, Beijing, China 57 Neurocognitive Function in Africans Failing First-Line ART and Responses to Second Line Andrew D. Kambugu 1 ; JenniferThompson 2 ; James Hakim 6 ; DinahTumukunde 10 ; Joep van Oosterhout 7 ; Anne Hoppe 2 ; Charles Kwobah 9 ; SarahWalker 2 ; Nicholas Paton 8 On behalf of the EARNESTTrialTeam 1 Infectious Diseases Institute, Makerere University Kampala, Kampala, Uganda; 2 University College London, London, United Kingdom; 3 Joint Clinical research Centre, Kampala, Uganda; 4 Queen Elizabeth Central Hospital, Malawi, Blantyre, Malawi; 5 AMPATH, Kenya, Eldoret, Kenya; 6 University of Zimbabwe, Harare, Zimbabwe; 7 Dignitas International, Zomba, Malawi; 8 National University of Singapore, Singapore, Singapore; 9 Moi University College of Health Sciences, Eldoret, Kenya; 10 Joint Clinical Research Centre, Kampala, Uganda 58 Compartmentalized HIV Rebound in the CNS After ART Interruption Sara GianellaWeibel ; Michelli Faria de Oliveira; Konrad Scheffler; Matt Strain; Antonio De laTorre; Scott Letendre; David M. Smith; Sergei L. Kosakovsky Pond; Ronald J. Ellis University of California San Diego, La Jolla, CA, US 59 Impaired Blood-Brain Barrier Integrity Is AssociatedWith Neuronal Injury in HIV Birgitta Anesten 1 ; Lars Hagberg 1 ; Henrik Zetterberg 2 ; Staffan Nilsson 3 ; Bruce J. Brew 4 ; Dietmar Fuchs 5 ; Richard Price 6 ; Magnus Gisslén 1 1 University of Gothenburg, Gothenburg, Sweden; 2 University of Gothenburg, Gothenburg, Sweden; 3 Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden, Gothenburg, Sweden; 4 University of New South Wales, Sydney, Australia; 5 Division of Biological Chemistry, Biocenter, Medical University, Innsbruck, Austria, Inssbruck, Austria; 6 University of California San Francisco, San Francisco, CA, US 60 Cortical and Subcortical Brain Volumes in Primary HIV Infection Patrick W. Wright 1 ; Ashmit Pyakurel 3 ; Kevin Robertson 4 ; Julia Peterson 5 ; Henrik Zetterberg 7 ; Dietmar Fuchs 6 ; Richard Price 5 ; Dieter Meyerhoff 5 ; Serena Spudich 2 ; Beau Ances 1 1 Washington University School of Medicine, Saint Louis, MO, US; 2 Yale University School of Medicine, New Haven, CT, US; 3 Louisiana Tech University, Ruston, LA, US; 4 University of North Carolina, Chapel Hill, NC, US; 5 University of California San Francisco, San Francisco, CA, US; 6 Innsbruck Medical University, Innsbruck, Austria; 7 University of Gothenburg, Gothenburg, Sweden 61 IRF4 Transcription Factor AssociatedWith Integrated HIV DNA in Brain Macrophages Benjamin B. Gelman 1 ; Joshua G. Lisinicchia 1 ;Tetyana P. Buzhdygan 1 ;Vipulkumar Patel 1 ;

Tyler Clement 1 ; Samantha A.Trevino 1 ; Kristofer R. Jennings 1 ; Dennis L. Kolson 2 1 University of Texas Medical Branch, Galveston, TX, US; 2 University of Pennsylvania, Philadelphia, PA, US

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CROI 2015