2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Slide 49of 152

Virologic Responses on Antiretroviral Therapy Virologic Blip

1,000,000

100,000

AntiretroviralTherapyStarted

10,000

1,000

100

50

10

1

HIV RNA (copies/mL)

0 4 8 12 16 20 24 28 32 36 40 44 48 52

Weeks

After virologic suppression, an isolated detectable HIVRNA level followed by return to virologic suppression.

Source: 2016 DHHS Antiretroviral Therapy Guidelines. AIDS Info.

Slide49of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Latently Infected CD4+ Lymphocytes

HIV Infected Cells

HIV virions

Antiretroviral Rx

Uninfected Activated CD4+ Lymphocytes

Uninfected Resting CD4+ Lymphocytes

M Saag, UAB

Slide50of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Slide 51of 152

Virologic Responses on Antiretroviral Therapy Virologic Failure

1,000,000

100,000

AntiretroviralTherapyStarted

10,000

1,000

100

50

10

1

HIV RNA (copies/mL)

0 4 8 12 16 20 24 28 32 36 40 44 48 52

Weeks

Source: 2016 DHHS Antiretroviral Therapy Guidelines. AIDS Info.

Slide51of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.