2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Change in Weight Overtime – NA-ACCORD Bourgi et al CROI 2019

Slide34of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Change in Weight Overtime – NA-ACCORD Bourgi et al CROI 2019

Slide35of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Long-term weight gain (mean 2.0 years)

Weight gain after ~2 years, comparing ART regimens in adjusted analyses

N=2999

n

∆kg/6mos

95%CI

P-value

Years on regimen (EFV ref)

427

0.66

0.38

0.10

0.01

Reg typexYearson regimen

349

1: RPV

-0.08 -0.47 0.30 0.67

96

1.44

2: ATV

0.62

-0.20

0.14

263

1.61

3: DRV

1.07

0.53

0.00

99

4: RAL

0.55

-0.13 1.23

0.11

790

5:EVG/TDF

0.24

-0.10 0.58 0.16

7: DTG/TDF a

235

0.64

1.17

0.12

0.02

9: DTG/ABC c

383

0.75

0.37

1.14 0.00

Meannumberofobservations perperson =8.9 * TAF regimens not includedasmean followup time is shorter due tomore recent approval a DTG/TDF tested different vs EFV,RPV c DTG/ABC tested different vsEFV,RPV, EVG/TDF

Slide36of65FromMSSaag,MDatNewOrleans, LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.