2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Guidelines for the Use of Antiretroviral Agents in HIV-1- Infected Adults and Adolescents: When to Start

• Antiretroviral therapy (ART) is recommended for all HIV-infected individuals to reduce the risk of disease progression. • ART also is recommended for HIV-infected individuals for the prevention of transmission of HIV. • Patients starting ART should be willing and able to commit to treatment and understand the benefits and risks of therapy and the importance of adherence.

Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Last updated July 10, 2019

Slide4of 50FromSC Johnson, MD atNewOrleans, LA,December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Antiretroviral Therapy: Approved agents in Seven Mechanistic Classes

Entry Inhibitors: Target CD4, Fusion, or CCR5

Integrase Inhibitors

Nucleus

Integrase

RNA

Protease

DNA

Reverse Transcriptase

HIV

CD4+ T-Cell

Protease Inhibitors

Reverse Transcriptase Inhibitors: NRTIs (Nucleosides, Nucleotides) and NNRTIs

Slide5of 50FromSC Johnson, MD atNewOrleans, LA,December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Antiretroviral Timeline: 1987-2019

Slide6of 50FromSC Johnson, MD atNewOrleans, LA,December 4-7, 2019, Ryan WhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.