2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Co-morbid conditions common in HIV-infected adults HIV-infected adults age 50-55 similar to uninfected adults > 65

Slide25of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA. Schouten J AIDS 2012

T cell “ activation ” is lower in treated than untreated adults, but consistently higher than “ normal ”

P< 0.001

80

P< 0.001

60

40

% CD38+HLADR+ CD8+ T Cells 0 20

HIV Negative (n=82) I + Untreat d (n=82)

Non- Controller (n=65) HIV + ART (n=65)

HAART (n=132)

HIV – (n=132)

Hunt etal JID 2003,PLoS ONE2011and unpublished

Slide26of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.

Early ART Also Appears to Reduce Residual T Cell Activation during ART

Jain et al, CROI 2011

Slide27of39FromMSSaag,MDatNewOrleans,LA,December4-7,2019,RyanWhiteHIV/AIDSProgramCLINICALCONFERENCE, IAS  USA.