2019 Ryan White HIV/AIDS Program CLINICAL CONFERENCE

Policy statements on U=U

On September 27, 2017, the US CDC sent out a “Dear Colleague” letter stating:

“…. people who take ART daily as prescribed and achieve and maintain an undetectable viral load have effectively no risk of sexually transmitting the virus to an HIV-negative partner.”

Slide35of58FromHScott,MD,MPHatNewOrleans,LA,December4-7, 2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Condom Effectiveness

Heterosexuals (Giannou et al, Expert Rev PharmacoeconOutcomesRes 2016) ▫ Meta-analysis of 25 studies, >10,000 couples ▫ Overall effectiveness: 71-77%

MSM (Smith et al, JAIDS 2015;68:337-344) ▫ Data from 2 large cohorts ▫ 70% effective

Slide36of58FromHScott,MD,MPHatNewOrleans,LA,December4-7, 2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.

Underutilization of PrEP in Partners of HIV positive MSM

Beer et al, CROI 2018,#1052

Slide37of58FromHScott,MD,MPHatNewOrleans,LA,December4-7, 2019,RyanWhiteHIV/AIDS ProgramCLINICAL CONFERENCE, IAS  USA.